ANNUAL FINANCIAL
REPORT 2021
This document is a free non-binding translation into English prepared for the convenience of
English-speaking readers, for information purposes only, of the French language Annual Fi-
nancial Report as filed with the Autorité des Marchés Financiers on April 26 2022 in accord-
ance with Article L 451-1-2 of the Monetary and Financial Code.
In the event of any ambiguity or conflict between corresponding statements or items contained
in this English translation and the original French version, the relevant statements or items of
the French version shall prevail. The free translations of the auditor’s reports presented in this
document apply to the French version of the financial statements
Copies of this Annual Financial Report are available free of charge at the registered office of Aelis
Farma SA, 146 rue Léo Saignat Institut François Magendie 33000 Bordeaux.
This annual report can also be consulted freely on the Company's website (https://www.ae-
lisfarma.com) as well as on the centralized storage site for regulated information of listed companies
managed by the French Department of legal and administrative information (https://www.info-financi-
ere.fr).
TABLE OF CONTENTS
2
3
Section 1 - Statement by the person responsible for the
annual financial report
1.1. Person responsible for the annual financial report
Pier Vincenzo Piazza, Chief Executive Officer of Aelis Farma.
1.2. Responsibility statement
« I certify, to the best of my knowledge, that the accounts have been drawn up in accordance with
the applicable accounting standards and give a faithful representation of the assets, financial situ-
ation, and results of the Company and that the management report below presents a faithful pic-
ture of the development of the business, results and financial situation of the Company and that it
describes the main risks and uncertainties that it faces ».
April 26, 2022,
Pier Vincenzo Piazza,
Chief Executive Officer of Aelis Farma
1.3. Financial Information Officer
Mrs. Valérie Scappaticci
Chief Financial Officer
Address: 146 rue Léo Saignat 33077 Bordeaux France
Phone: +33 (0) 5 57 57 37 70
5
Section 2 - Definitions
In this annual financial report:
The term “AMF” refers to the Autorité des Marchés Financiers acting as competent au-
thority pursuant to Regulation (EU) 2017/1129;
The terms the “Company” or “Aelis Farma” designate the company Aelis Farma SA (a
Public Limited Company whose head office is located at 146 rue Léo Saignat Institut
François Magendie 33000 Bordeaux and registered under number 797 707 627 RCS Bor-
deaux);
The term “Registration Document” refers to the registration document approved by the
AMF on January 14, 2022, under number I. 22-003;
The term “Annual Financial Report” refers to this annual financial report on the financial
statements for the financial year ended December 31, 2021.
6
Section 3 - Management report
3.1. Situation and development of the Company’s activity
during the financial year
Research and development activity
For compound AEF0117, 2021 was particularly focused on:
the final validation of the results from our phase 2a clinical study in the United States,
which was submitted to the American drug agency, the FDA, in April 2021. This study
confirms the absence of significant side effects in cannabis drug addicts and provides the
first evidence of efficacy in humans for AEF0117;
development and validation with the FDA and our partner Indivior PLC of the protocol for
the next phase 2b study. This study coordinated by Columbia University (New York), may
involve 330 patients and 9 clinical centers over a period of 2 years, and will confirm the
effectiveness of AEF0117 as a treatment for cannabis use disorders;
launch of additional pre-clinical toxicity studies, and the production of new clinical batches
of the pharmaceutical product which will be used in the phase 2b clinical study.
For AEF0217, the Company's second drug candidate, targeting applications in the field of cogni-
tive deficits and in particular in the field of Down syndrome, 2021 was focused on:
regulatory filing to the Spanish Medicines Agency (AEMPS) for authorization to start
phase 1 studies in healthy volunteers;
production of technical and clinical batches of pharmaceutical products (dispersible tab-
lets) intended for phase 1 studies;
obtaining from the AEMPS authorization to administer AEF0217 to humans on Septem-
ber 19, 2021;
initiation of the phase 1 clinical program (early October 2021). The results of the first co-
horts of healthy volunteers do not show any notable adverse effects and show good phar-
macokinetic characteristics of the compound;
launch of additional preclinical toxicity studies (phototoxicity and toxicity 6-9 months)
The upstream research program (Discovery program) was mainly focused on the mechanism of
action of CB1-SSi and on the characterization of new compounds.
Human resources and governance
In terms of human resources, the Company made numerous hires during the year:
three R&D project managers and two laboratory technicians within the Discovery division;
two pharmaceutical project managers;
two preclinical project managers;
a clinical trials manager;
a development project manager;
7
two administrative staff (versatile accountant and lawyer).
As at December 31, 2021, the Company had 22 full-time employees (compared to 9 employees
as at December 31, 2020), and an apprenticeship contract (quality).
During the 2021 financial year, 1,500 BSA were granted to strategic consultants of the Company
and 1,789 BSPCE to employees of the Company.
As of the date of this report, all employees with more than one year's seniority, researchers under
scientific competition contracts and the main key consultants are shareholders of the Company
and/or hold securities giving access to the capital (BSA or BSPCE).
Financial resources
On a financial level, there were several notable developments during 2021:
the signing of an industrial partnership in the form of an exclusive license option agree-
ment for the industrial property of AEF0117 in the field of cannabis-related disorders, with
Indivior PLC. The first scheduled payment under this agreement, for USD 30 million, was
paid in June 2021;
the collection of the first advances concerning the ICOD (1.5m) and FEDER2020 (0.2m)
subsidies and the balances of Deeptech (0.4m) and CRNA2019 (0.25m) financings;
preparation for the Company's initial public offering on the Euronext Paris regulated mar-
ket (compartment B), which took place on February 18, 2022.
Investments
The main acquisitions for the 2021 financial year relate to laboratory equipment. The investments
will enable the Company to work on the development of its new library of molecules for which it
will hold full ownership of the new discoveries and patents that it will file.
3.2. Review of accounts and results
The income statement and the summary balance sheet, prepared according to French account-
ing principles, are as follows:
INCOME STATEMENT
In thousand euros
12/31/21
12/31/20
Revenue
9,075
643
-
70
Other operating revenue
Operating revenue
9,718
79
70
Material purchases and inventory changes
Other purchases and external expenses
Wages, social charges, and salaries
Other expenses and depreciation
Operating result
3
3,800
2,090
1,849
1,900
47
2,403
1,469
52
(3,856)
(76)
457
Financial result
Exceptional result
518
Research tax credit net of company tax
Profit (loss) for the financial year
891
692
3,356
(2,783)
8
BALANCE SHEET
In thousand euros
12/31/21
12/31/20
Intangible and tangible fixed assets
Financial fixed assets
Total fixed assets
Receivables and prepaid expenses
Inventory
269
50
69
50
319
119
3,300
17
1,396
-
Cash and cash equivalents
Total current assets
TOTAL ASSETS
24,710
28,028
28,347
2,689
1,039
5,837
2,712
528
4,538
5,935
6,054
(1,845)
1,000
5,632
1,231
35
Equity
Other equity
Financial debts
Operating liabilities
Other liabilities
Deferred revenue
15,541
28,347
-
TOTAL LIABILITIES
6,054
The financial information presented in this section comes from the Company's annual financial
statements drawn up in accordance with the presentation rules and valuation methods provided
for by the regulations in force.
Readers are invited to read this analysis of the financial position and results of the Company to-
gether with the financial statements of the Company and their accompanying notes presented in
Section 6 of the Annual Financial Report and any other financial information appearing in the Fi-
nancial Report.
A summary of the financial statements for the previous year ended December 31, 2020 is pro-
vided for comparison.
During the financial year ended December 31, 2021, revenue amounted to €9,075,395 compared
to €0 for the previous financial year. It corresponds to the portion of income from the license op-
tion contract with Indivior PLC recognized in fiscal year 2021.
The amount of other operating income amounted to €642,644 compared to €70,389 for the previ-
ous financial year. These mainly relate, in fiscal year 2021, to the foreign exchange gain linked to
the signing of the contract with Indivior PLC settled in dollars.
The purchases of materials and changes in stocks is €79,458. This amount includes the pur-
chases of raw materials of 96,908 whereas it was €2,653 for the previous financial year. They
correspond mainly to consumables for the Company's laboratory.
The associated change in inventory amounts to -€17,450 as of December 31, 2021 and corre-
sponds to the constitution of the consumables for the Company's laboratory.
The number of other purchases and external charges amounted to €3,799,524 compared to
€2,402,856 for the previous financial year, i.e. a change of +58.13%. This item includes research
and development expenses entrusted to subcontractors, costs of filing and maintenance of pa-
tents for which the Company is licensed, and more incidentally consulting fees. The evolution of
9
expenses is in line with the Company's annual research program described in the introduction (§
3.1).
Salaries, wages and social charges amounted to €2,089,783, among which salaries and wages
amounted to €1,518,698 compared to €1,163,595 for the previous financial year, i.e. a change of
+30.52%, in line with the evolution of the Company's workforce described above, and taking into
account the allocation of exceptional bonuses for the contribution of employees to the signing of
the license option agreement with Indivior PLC.
Social charges amounted to €571,085 compared to €304,820 for the previous financial year, i.e.
a change of +87.35% linked to the evolution of the payroll and the end of the JEI (Jeune Entre-
prise Innovante) status of the Company for the first year.
The workforce at the end of the financial year was 22 full-time people and one apprenticeship
contract (quality) compared to 9 for the previous financial year.
Other charges and depreciation amounted to €1,849,114 and includes:
the amount of taxes and duties amounted to €63,323 compared to €18,015 for the previ-
ous financial year, i.e. a change of +251% linked to the added value contribution and the
social solidarity contribution due for the financial year 2021 taking into account the recog-
nition of revenue for the 2021 financial year;
depreciation and provisions, which amounted to €13,615 compared to €8,456 for the pre-
vious financial year. The amount of other expenses, which amounted to €1,771,176 com-
pared to €26,266 for the previous financial year. They mainly relate to the royalty due to
AEF0117 patent owners following the signing of the option license agreement with In-
divior PLC.
The operating result shows a profit for the financial year of €1,900,158 compared to -€3,856,272
for the previous financial year.
The financial profit is €47,382 against a loss of -€76,162 for the previous financial year (change
linked to the exchange gain recognized at the end of the financial year on the cash balance in
USD not being used to hedge futures).
The result for the 2021 financial year shows a profit of €3,356,001 after considering:
the extraordinary result of €517,675 for the financial year compared to a result of
€457,085 for the previous financial year: this result relates to the subsidies financing the
research expenses incurred within the framework of the FEDER and ICOD programs;
taking into account a research tax credit of €1,089,465, and after deduction of corporation
tax charge of -€198,679, the net income tax balance is a tax credit of €890,786. This
amount should be compared to the net tax credit of €691,703 for the previous financial
year. The change in net tax position is linked to a higher research tax credit for 2021, in
connection with the evolution of eligible research and development expenses (including
payroll) incurred during the financial year compared to the previous financial year.
As of December 31, 2021, the Company's balance sheet total amounted to €28,346,699, against
€6,054,228 as of December 31, 2020.
Fixed assets amount to €318,930 compared to €119,562 for the previous financial year. They are
mainly made up of tangible fixed assets for €178,763 compared to €9,381 for the previous finan-
cial year, i.e., an increase of +€169,382 in connection with the equipment of the Company's la-
boratory.
10
Receivables and deferred expenses amounted to €3,299,767, compared to €1,396,525 for the
previous financial year. They correspond to:
prepaid expenses for €1,606,695 as of December 31, 2021 compared to €56,526 as of
December 31, 2020, the increase of which corresponds to research and development
contracts involving sequential performance and the share of costs incurred in the 2021
financial year in direct connection with the capital increase during the initial public offer-
ing;
the claim for income net of tax on profits of €890,768 for the financial year, compared to
€691,703 for the previous financial year;
the VAT receivable for €367,581, compared to €107,454 for the previous financial year.
Considering the value of inventory and cash at closing, respectively €17,450 and €24,710,551,
current assets amount to €28,027,769 compared to €5,934,666 for the previous financial year.
Equity amounted to €2,689,153 (compared to €(1,844,693) for the previous financial year), taking
into account the result for the financial year of €3,356,001 and the allocation of the result of the
previous financial year of €(2,783,646) on the issue premium for €934,958, and on retained earn-
ings for €1,848,688.
Other equity amounts to €1,039,147 compared to €1,000,000 for the previous financial year and
corresponds to conditional advances granted to the Company.
Financial debts amount to €5,836,580 for the financial year compared to €5,631,900 as of De-
cember 31, 2020 and consist of:
convertible bond debt for €2,234,217, compared to €2,219,025 for the previous financial
year. These bonds were converted into shares on the date of the IPO, which took place
on February 18, 2022, which led to the cancellation of this debt after the closing date;
debt from credit institutions for €2,102,296 compared to €2,162,808 for the previous fi-
nancial year;
and other loans and debts for €1,500,067 compared to €1,250,067 for the previous finan-
cial year.
Operating debts amounted to €2,711,778 as of December 31, 2021, compared to €1,231,230 as
of December 31, 2020, they are mainly made up of supplier debts for €2,243,093, compared to
€927,506 for the financial year previous.
The amount of miscellaneous debts, €526,983, compared to €31,500 for the previous financial
year, corresponds to the valuation difference of derivative financial instruments, relating to hedg-
ing transactions.
Deferred income amounted to €15,541,000, compared to €0 for the previous financial year and
corresponds to the share of Indivior PLC revenue associated with the future performance obliga-
tion, recognized over time following costs during the execution of the phase 2b of AEF0117 pro-
gram.
It should be recalled that the Company had benefited for the 2020 financial year, and for the last
year, from the status of Young Innovative Company (JEI, Jeune Entreprise Innovante) and is eli-
gible for the research tax credit mechanism in respect of its research and development expenses.
11
3.3. Progress made and difficulties encountered
Please refer to Section 3.1 above which describes the progress of the research and development
program over the year, the various hires made, and the signing of the license option agreement
with Indivior PLC.
3.4. Main risks and uncertainties facing the Company
The objective of the Company's risk management policy is to identify and analyze the risks the
Company faces, to define the limits within which the risks must be kept and the controls to be im-
plemented to ensure this.
3.4.1. Risk management by governance and management bodies
The management of strategic, operational and financial risks, and of the Company's internal con-
trol, is carefully monitored and managed by the Company's Management, the Audit Committee
and the Company's Board of Directors. As part of the preparation of the IPO project, the Compa-
ny's Management has initiated a broader and more structured project to identify risks, to assess
them and to manage them.
The main mission of risk management is to identify, assess and prioritize risks as well as to assist
the management of the Company in choosing the most appropriate risk management strategy
and, in order to limit the significant residual risks, define and monitor related action plans.
The main objective of internal control is to enable the Company to achieve its objectives, by de-
fining and implementing the appropriate internal controls in order to address the risks identified in
the conduct of the Company's activities.
The identification and treatment of the major risks that the Company could face are carried out
under the responsibility of the general management, the operations department, and the financial
department. Risk management and internal controls are overseen by the Chief Executive Officer,
the Director of Operations and the Finance Department.
The Company's overall risk management and internal control system is based on several ele-
ments, in particular, the control of technological risks, the control of other operational risks, and
the monitoring of the Company's internal control system.
Systems put in place by the Company to respond to these challenges include in particular:
the establishment of active governance, through a Board of Directors composed of mem-
bers representing long-standing investors in the Company, and independent directors
with recognized experience and skills in the field of biotechnology in which the Company
operates. The Board of Directors meets at least 4 times a year but is convened when any
key development in the management or strategy of the Company justifies it; the points
discussed during Board meetings include a legal and financial agenda, a progress report
on research and development, a progress report on the Company's other operations such
as, for example, human resources, actions taken in terms of communication, potential
partnerships and search for dilutive and non-dilutive financing. Regular updates are car-
ried out, as necessary, with the Chairman of the Board of Directors in order to ensure the
quality and relevance of exchanges within the Board. The Chairman of the Board of Di-
rectors ensures that each member or censor expresses his opinion on the points pre-
sented.
12
authorizations are obtained in the event of anticipated overspending of certain budget en-
velopes initially defined, of new studies programmed, or of reorientations in the scientific
development programs, either through budget revisions, or through specific deliberations.
Committees have been set up and meet at least twice a year (Audit Committee and Compensa-
tion Committee):
the Audit Committee deepens the budget preparation process at the end of the year to
ensure the relevance and consistency of the proposed expenditure envelopes. It also
meets for the review of the annual accounts, reviews the accounting options adopted, the
differences between the expenses incurred and the expenses budgeted, and exchanges
with the auditor on the content of its mission, the key elements analyzed during its work
the identified risks and their accounting translation;
the Compensation Committee proposes to the Board the objectives of the Chief Execu-
tive Officer at the beginning of the year, on the basis of the Company's strategic and fi-
nancial plan; these objectives may relate in particular to meeting deadlines for key sched-
uled studies, filing patents to improve the Company's industrial property protection, ob-
taining dilutive or non-dilutive financing, recruiting key personnel. At the end of the year,
the Committee meets to assess the achievement of the identified objectives, also taking
into account other events occurring during the year which would have focused the efforts
of the management team and proposes to the Board of Directors the corresponding varia-
ble compensation. As of the admission of the Company's shares to the regulated market
of Euronext Paris, the Compensation Committee is also in charge of appointments and
social and environmental responsibility;
on an operational level, the Company's internal control is based in particular on the sepa-
ration of tasks and the strong involvement of managers in expenditure commitments, set-
tlement authorizations and payments to third parties;
the development and regular monitoring of the expenditure budget, with fine granularity,
provides a predictive management tool for any budgetary changes thanks in particular to
regular and frequent exchanges with the key operational players of the Company. The im-
plementation of cost accounting and time tracking tools per employee strengthens the
Company's ability to provide reliable and relevant information to the various stakeholders
(shareholders, funders, banking partners, etc.).
3.4.2. Management of risks related to the development of the
company's products
The Company's R&D activities are focused on the development of AEF0117, its most advanced
product candidate, and AEF0217, as well as the development of new drug candidates. The value
of the Company is significantly dependent on the conduct and success of preclinical studies and
future clinical trials of present and future drug candidates.
The Company’s strategy for its Research and Development activities is based on the following
steps:
diversification of its product portfolio: in 2018 the Company initiated the development of
AEF0217 in the cognitive deficits of Down syndrome (trisomy 21) in order to add a sec-
ond drug candidate to the Company's pipeline. The entry into the clinical phase of this
compound since October 2021 (phase 1 program) and the financing through the ICOD
program (H2020), allow the Company to consider carrying out other phase 2 clinical
13
studies. to establish evidence of efficacy in other CB1 receptor-mediated cognitive defi-
cits. Finally, the Company aims to strengthen the development and qualification of its
CB1-SSi library with the aim of selecting a third drug candidate than can enter a regula-
tory preclinical development stage;
establishment of strategic partnerships with Key Opinion Leaders (KOL) and key institu-
tions in the targeted areas. Thus, the development of AEF0117 in cannabis addiction has
been part of a collaboration since 2014 with the NIDA (National Institute on Drug Abuse,
an institute that is part of the NIH, the National Institute of Health of the United States).
Beyond the significant funding provided by NIDA, the Company has benefited from its
support, particularly in the development of preclinical proofs of concept in monkeys, and
in the definition of the clinical development strategy and in the interactions with regulatory
authorities (FDA). In the case of AEF0217, the meeting of a scientific committee made up
of KOLs in the field of cognitive disorders allowed the validation of the preclinical proofs of
concept obtained by the Company and was a key step for the decision to initiate the stud-
ies necessary for the first administration of this compound in humans. Thanks to the
ICOD project funded by the European Commission's H2020 scheme, the Company was
able to bring together European KOLs and a network of clinical centers around its
AEF0217 development project that will conduct the phase 2 study in cognitive deficits of
Down syndrome;
strengthening of clinical teams, under the aegis of Helle Mengel, Director of Clinical De-
velopment of the Company, in order to benefit from the expertise of specialists in clinical
development and in regulatory issues specific to the field of neurosciences. The contribu-
tion of Ms. Mengel and the clinical team is also essential in the process of selecting exter-
nal service providers to supervise the progress of the studies as well as in the choice of
clinical centers to secure the recruitment and the realization operational studies. The
Company believes that this team’s in-depth knowledge of the characteristics of the inno-
vative mechanism of action of the Company's drug candidates, proofs of preclinical con-
cepts, and pharmacological safety studies, are all assets to allow the carrying out of stud-
ies targeting the right therapeutic objectives and minimizing the risks of execution. The
clinical team’s in-depth knowledge of best practices in the sector, particularly in the field
of quality control and auditing, has enabled the implementation of internal procedures that
comply with the standards of the sector in which the Company operates. Regular interac-
tion with the Company's Operations Department ensures a process of exchange allowing
the anticipation of difficulties, high degree of reactivity in the face of any operational haz-
ards encountered, and the identification of and control over any delays and budget over-
runs that any project of this magnitude is faced with.
the Company constantly monitors developments in the field of CB1 receiver modulators in
order to identify developments, markets, potential competitors, and to be in a position,
where appropriate, to establish partnerships with academic groups or private structures
developing relevant technologies for its strategy.
3.4.3. Management of risks related to regulatory authorizations
and the future marketing of the company's products
Having the potential to be the first company able to develop and, if successful, market a drug in
the two main indications targeted by the Company (cannabis addiction and cognitive deficits re-
lated to Down syndrome), the Company is faced with the risks inherent in the absence of a clear
regulatory path with the regulatory agencies.
14
To meet these challenges, the Company has a policy of surrounding itself with external skills very
early in the development process of its products. To this end, it works in close collaboration with
renowned regulatory consulting firms, having participated in the marketing of numerous mole-
cules. These interactions allow the Company to develop key supports for regulatory development,
in particular the Quality Target Product Profile (QTPP), the Target Product Profile (TPP), as well
as the anticipation of complete development plans detailing the interactions necessary with the
regulatory agencies and considering the possibility of benefiting from accelerated regulatory pro-
cedures (fast track, orphan drug in particular).
In addition, for AEF0117, the Company thus requested, at the end of the phase 2a clinical study,
a "type B meeting" with the FDA to discuss the overall development plan for this drug candidate
for the treatment of disorders related to the excessive use of cannabis as well as the protocol for
the future phase 2b. The signature of the industrial partnership with Indivior PLC in June 2021 al-
lows it today to benefit from exchanges with a specialist in the addiction sector: the recurring Joint
Steering Committees between the two parties allow the Company to benefit from the expertise of
this Group in the “downstream” regulatory and commercial stages (including the future coverage
of treatments by the health agencies of the various key target countries).
In the case of AEF0217 in Down syndrome deficits, the constitution of the ICOD consortium, fi-
nanced by a European H2020 program, allows the Company to structure a development strategy
shared with the most recognized European experts in this field, and thus to secure the areas of
development selected.
These various exchanges, and participation in international congresses in the Company's areas
of expertise, allow the Company to carry out scientific and strategic monitoring.
Issues relating to the competitive positioning of the Company's drug candidates and technologies
are mainly analyzed internally, with the possible acquisition of relevant studies, and solicitation of
the KOL network from which the Company benefits.
3.4.4. Management of legal, compliance and intellectual property
risks
3.4.4.1. Product liability
In order to protect itself against the risk of incurring liability in the event of damage generated by
the use of its products, specific insurance policies are taken out by the Company for each of the
clinical trials for which the Company is the promoter. Pricing and guaranteed amounts depend on
the regulations and local legislation applicable to the clinical investigation center concerned. In
France, the Public Health Code provides for an insurance obligation for sponsors of clinical trials.
In countries where there is no such obligation, the Company has nevertheless taken out an insur-
ance policy covering its liability for carrying out clinical trials. The overall amount of the premiums
depends on the number of patients included in the trials and their geographical location. The
Company believes that it is sufficiently covered for each of the trials in progress.
3.4.4.2. Intellectual property risk management
Since its creation, the Company has implemented an intellectual protection policy internally and
with regards to third parties.
15
Internally, the teams of researchers are made aware of the key issues related to intellectual pro-
tection. Any exchange with potential partners, whether academic or commercial, is done in com-
pliance with the rules of protection by the establishment of confidentiality agreements, MTA (Ma-
terial Transfer Agreement, or agreements for the use of the Company’s compounds) and review
of the contractual clauses by the internal legal team of the Company, and by specialized consult-
ants if necessary. Thus, the Company has two in-house employees combining legal and scientific
skills to manage intellectual property issues and to be the expert interlocutors with industrial prop-
erty consulting companies.
Externally, the Company has recourse to international consulting firms, including those based in
the United States, to ensure the quality of the patent application files filed with regard to the regu-
lations of the various countries, but also to exchange with the examiners during the period When
applications are assessed.
Aelis Farma pursues an active strategy to protect its inventions and its intellectual property, favor-
ing patents conferring strong protection on the drug candidate molecule itself (composition pa-
tent), and subsequently strengthening this intellectual property by filing patents of specific appli-
cation in the therapeutic fields or therapeutic indications of interest.
By systematically protecting the structure of the molecules of drug candidates developed by the
Company, and their main uses, the Company aims to prevent any commercial exploitation of its
drug candidates by any third party in any field during the term of validity of composition patents
and reinforced in the therapeutic applications of interest by application patents.
The Company also monitors the products marketed by its competitors and will take action for in-
fringement if such actions are revealed.
All patent applications and external patents brought to the Company's attention, in particular dur-
ing the Company's application assessment procedures, are subject to scrupulous examination as
to their possible impact on the freedom to operate the Company's technologies.
3.4.4.3. Compliance with personal and medical data protection
regulations
The Company also takes a legal approach to securing every project by protecting the rights of in-
dividuals in legal frameworks such as contracts, privacy statements and consent forms. The
Company implements procedures to protect the personal data of its employees, patients,
healthcare professionals and other partners with whom it interacts.
In the context of clinical trials carried out in the United States, the Company uses service provi-
ders who are compulsorily or voluntarily subject to the General Data Protection Regulations and
as such have the level of data protection required by Europe.
3.4.5. Management of risks related to company operations
Issues relating to the selection and monitoring of partners in charge of the production of the Com-
pany's products, and clinical and preclinical developments are closely managed by the Compa-
ny's Operations Department. The process put in place is based on almost systematic competition
between the main partners, the taking into account in this process of their financial strength, their
16
ability to offer the Company scalable solutions to enable these relationships to develop over time
(capitalization on the knowledge and know-how of the partners).
As far as possible, the Company uses first-rate service providers, whose size allows them to deal
with any contingencies by relocating the activity in the event of force majeure, and who can en-
sure the implementation of rapid remediation plans if necessary. In accordance with practices in
the pharmaceutical industry, the Company has implemented an internal quality process focused
in particular on the evaluation of service providers and the monitoring of identified deviations. The
Company carries out quality audits of the main service providers in accordance with the stand-
ards in force in the pharmaceutical industry.
The search for diversification of supply sources is underway to secure materials qualified as stra-
tegic.
Finally, the Company's recruitment policy, which makes it possible to diversify experience and in-
tegrate people with knowledge of the various players in the sector, makes it possible to benefit
from feedback and to develop the Company’s practices.
3.4.5.1. Risks related to the absence of a sales, marketing and
distribution organization
The Company's business model is based on the development of a drug candidate until it is mar-
keted and on finding, at least initially, partners for its marketing. Thus, for AEF0117, the Company
has demonstrated its ability to implement such a strategy by signing an option license agreement
for the marketing of this drug candidate in the field of pathologies induced by the excessive use of
cannabis. The management team has therefore acquired valuable experience in negotiating and
setting up partnerships, including through the use of specialized external advisers so that they
are at its side if opportunities are identified for the other drug candidates.
In order to implement this partner search strategy, the Company monitors players in the sector
and communicates regularly to publicize its compounds. Its ambition is to intensify its participa-
tion in numerous congresses and meetings in the biotechnology sector to strengthen its visibility.
Listing on the regulated market is part of this strategy.
3.4.5.2. Key employee management policy
The Company has implemented a recent recruitment policy allowing it to duplicate the Company's
key positions, diversify the profiles of its employees and cope with the evolution of its Research
and Development programs. In this context, its salary policy aims to position its remuneration at
market level in order to attract talent on a national or even international level. Aelis Farma also
plans to continue its policy of granting profit-sharing tools in the Company's capital, open to all
employees of the Company, with the main criterion of retaining employees over time. In the cur-
rent context of changing working methods following the Covid-19 pandemic, the Company has
also put in place a device and the necessary technical means allowing it to switch to remote
working mode without loss of efficiency as soon as that might be necessary.
17
3.4.5.3. Cybersecurity risks
The organization of the Company's data is structured around a third-party data solution in the
cloud, reducing exposure to a targeted attack through the security and redundancy systems im-
plemented by this service provider. Strict internal procedures for changing passwords, updating
security software, and backing up redundant systems have been put in place.
For the security of its means of exchange and storage of clinical data, the Company uses service
providers with procedures that comply with the GDPR allowing the security of clinical data, includ-
ing their backup and their integrity.
3.4.5.4. Risks linked to the health crisis for general and clinical
operations
During the Covid-19 pandemic, the Company implemented a remote working policy favoring re-
mote work in accordance with government recommendations. This change was accompanied by
the provision of all the necessary tools and materials to facilitate remote working, as well as the
establishment of frequent and structured interactions to integrate new employees and strengthen
cohesion and 'team spirit. At the level of its service providers, it has set up frequent communica-
tion with its subcontractors to ensure the continuity of services under the best possible conditions,
or, where applicable, their discontinuation or controlled postponement. With clinical service pro-
viders, regular contacts are in place to assess their level of preparation, exposure and anticipa-
tion of risks related to clinical studies in a Covid environment.
3.4.6. Financial risk management
3.4.6.1. Funding and liquidity
The Company's highly capital-intensive activity has led it to develop approaches based on identi-
fying and anticipating financial needs. The management of these risks is based on:
a regular budget process, mainly oriented towards cash management and control of the
evolution of the R&D budget, shared internally between the various players within the
Company, and regularly supervised by the governance of the Company (Board of Admin-
istration, Audit Committee);
the search for non-dilutive financing by the management team, with national, European
and international partners. This search for funding has enabled the Company to benefit
from funding from Bpifrance, the Conseil Régional Nouvelle-Aquitaine and banking part-
ners, as well as subsidies from the European Union and the NIDA-NIH;
the search for dilutive financing from specialized investors and funds that have historically
supported the Company;
the initial public offering on the regulated market of Euronext (compartment B), carried out
after the closing in February 2022, allows the Company to diversify its sources of equity
financing by having the possibility of having recourse to the financial markets.
When significant financing is set up (fundraising, industrial partnerships), the funds made availa-
ble are placed with the Company's banking partners, on risk-free instruments.
18
3.4.6.2. The research tax credit (CIR)
The research tax credit constitutes a significant source of financing for the Company. In order to
respond in the most appropriate way to the evolution of the regulations and the complexity of the
applicable rules, the Company has set up an internal organization aimed at managing these is-
sues as well as possible, in particular for the purposes of selecting expenses and eligible service
providers, drawing up the appropriate documentation, and anticipating any adverse develop-
ments. This organization is based on:
the use of external expertise (accountant and firm specializing in this field and particularly
applied to the health sector);
the establishment of regular regulatory monitoring to anticipate changes, learn about case
law, ensure the quality of the documentation produced;
the implementation of a risk management process within the operational teams, in order
to identify, as soon as the order is placed, the eligibility of service providers and services
for the CIR mechanisms at the instigation of the Finance Department;
the qualification of the potential eligibility of expenditure as soon as the budget is drawn
up, making it possible to control the issues of financial flows linked to this mechanism;
the implementation of a time monitoring network adapted to the particularities of the Com-
pany's research activity and the eligibility or not of each of the milestones as defined by
the French Ministry of Research.
3.5. Use of financial instruments by the Company
The Company's exposure to foreign exchange risk is linked to the existence of expenses in a cur-
rency other than the euro (mainly in US dollars), the Company's functional currency and the
presentation currency of the financial statements.
In 2020, the Company had not implemented a foreign exchange risk hedging policy using hedg-
ing instruments.
In 2021, the Company chose to set up auto-hedging in dollars following the receipt of the $30 mil-
lion for the license option agreed with Indivior PLC. Thus, these funds in dollars will be used to
finance the future costs of the research program carried out in this currency (studies related to
AEF0117 in the United States), thus constituting a natural exchange rate hedge.
3.6. Company activity in terms of research and
development
The Company has developed a new pharmacological class, Signaling Specific inhibitors of the
type 1 receptor of the endocannabinoid system (CB1-SSi), which could make it possible to offer
viable treatments for certain pathological conditions linked to hyperactivity of the CB1 receptor,
the main receptor of the endocannabinoid system. CB1-SSi mimic a natural mechanism the brain
uses to combat CB1 receptor overactivity. This receptor is involved in the regulation of several
physiological functions and therefore in the occurrence of several brain diseases, thus giving ac-
cess to multiple therapeutic areas.
CB1-SSi seem capable of inhibiting only the cellular signals involved in the pathology while spar-
ing the normal physiological activity of the receptor. Thanks to this very innovative mode of
19
action, never tested before in humans, Aelis Farma was able to show that CB1-SSi are, to date,
not only effective but also well tolerated and devoid of significant side effects. This mode of action
is very different from that of previous generations of CB1 antagonists which blocked all receptor
activity resulting in severe side effects which made their use in humans difficult. For these rea-
sons, CB1-SSi promise to provide therapeutic solutions for diseases that currently have no treat-
ment.
The products developed by Aelis Farma are new molecular entities (NMEs) belonging to the gen-
eral chemical class of small molecules and to the new pharmacological class called Signaling
Specific inhibitors of the CB1 receptor of the endocannabinoid system (CB1-SSi).
Aelis Farma has two clinical-stage drug candidates:
AEF0117, the most advanced drug candidate, to combat the harmful effects of cannabis
and in particular Cannabis Use Disorders (CUD) which is the current definition of canna-
bis addiction in the diagnostic manual reference DSM-5. It is estimated that in the Euro-
pean Union, United States, Canada and Australia, 7.2 million individuals have been diag-
nosed with CUD, the DSM-5 definition of cannabis addiction. The Company's animal and
human studies with AEF0117 suggest that this compound may decrease both motivations
to use cannabis and the negative impact of cannabis on the brain. In addition, AEF0117
demonstrated favorable pharmacokinetic, toxicological, pharmaceutical and tolerability
characteristics confirming its potential for the treatment of CUD. The current development
program of AEF0117, carried out in collaboration with Indivior PLC, the leader in addiction
medicine, aims to carry out a phase 2b study, which should start in the first half of 2022,
in patients suffering from CUD and to conduct additional clinical and non-clinical studies
in order to prepare the entry of AEF0117 into confirmatory phase 3 studies.
AEF0217, the second drug candidate, is being developed for the treatment of cognitive
disorders, with the primary target being Down syndrome cognitive impairment (trisomy
21), a significant unmet medical need. An estimated 0.8 million people are living with
Down syndrome in the European Union, United States, Canada, Australia and Japan,
with an increasing prevalence due to late pregnancy and longer life expectancy for these
people. AEF0217 was able to restore working memory deficit in Down syndrome mice, a
key cognitive deficit in Down syndrome, without inducing identifiable behavioral or physio-
logical side effects within the therapeutic dose range. Thanks to this unique combination
of efficacy and safety, particularly important for the fragile Down syndrome population,
AEF0217 could allow a prodigious leap in the quality of life and social integration of peo-
ple living with Down syndrome. AEF0217 is currently in a phase 1 study in healthy volun-
teers, with no major adverse effects reported to date, and is expected to enter phase 1/2
in subjects with Down syndrome in the fourth quarter of 2022/first quarter of 2023.
Disorders linked to cannabis excessive usage and cognitive deficits associated with Down syn-
drome have been selected as a priority by Aelis Farma because they represent major unmet
medical needs, thus potentially opening up access to large markets. Aelis Farma is also develop-
ing several new CB1-SSi, now in early pre-clinical research, which could offer therapeutic solu-
tions for other brain diseases involving the CB1 receptor, such as attention deficit hyperactivity
disorder (ADHD), autism spectrum disorders, 22q11 deletion syndrome (an orphan disease asso-
ciated with hyperactivity and psychosis).
20
Aelis Farma has developed and operates a Research and Development (R&D) platform, which
enables the Company to discover drug candidates that act as specific modulators of target recep-
tor signaling. The Aelis Farma R&D platform is made up of three major components:
a library of new original molecules which modify the activity of the CB1 receptor in a spe-
cific and selective way of certain signaling pathways of this receptor. This library has al-
ready generated two drug candidates that are now in the clinical stage: AEF0117 for can-
nabis-related disorders and AEF0217 for cognitive deficits. It also contains several new
compounds that Aelis Farma is developing to treat other brain diseases that involve the
CB1 receptor;
an efficient research platform composed of: i. A screening laboratory using High Content
Screening techniques, which gives Aelis Farma the ability to identify molecules that act as
signaling specific inhibitors; ii. An original multifactorial screening procedure, which as-
sesses toxicity, bioavailability and formulation upstream in order to reduce the attrition
rate of the drug development pipeline; iii. Innovative behavioral models that aim to im-
prove the prediction of therapeutic efficacy in humans;
structuring partnerships with prestigious national and international partners who offer Ae-
lis Farma the best environment to implement the Company's programs.
3.7. Activity of subsidiaries and controlled companies
The Company has no subsidiary and does not control any company.
3.8. Foreseeable development and prospects
The Company's 2021-2025 development program includes a large number of clinical and preclini-
cal studies to advance research programs and enable them to reach the next stage of value crea-
tion:
for AEF0117: a phase 2b clinical study in the United States in cannabis use disorders
(CUD) which is planned to start in the first half of 2022 with the results are expected in
2024; in parallel, clinical and preclinical studies will be conducted to prepare for the transi-
tion of AEF0117 to phase 3;
for AEF0217: phase 1 clinical studies (whose results are expected in the fourth quarter of
2022), phase 1/2 (which is planned to start in the last quarter of 2022/first quarter of
2023) and phase 2b (which is planned to start in the event of success of phase 1/2, in the
last quarter of 2023) in the cognitive deficits observed in Down syndrome (also called tri-
somy 21). The Company is also considering an additional clinical study to assess the effi-
cacy of AEF0217 in another cognitive deficit;
early preclinical and then regulatory studies allowing to select and administer to humans
a new drug candidate from the Company's research platform (“Discovery” program).
The Company estimated that it had the necessary financial resources at the end of the 2021 fi-
nancial year to enable it to carry out the phase 2b study for AEF0117 in CUD and for AEF0217 in
cognitive deficits of Down syndrome, the completion of which is respectively scheduled for H1
2024 and H2 2024 and to repay financing agreed with third parties.
21
In order to finance its development and its future additional investments, the Company carried
out, after the closing, a capital increase within the framework of the admission of its shares to the
regulated market of Euronext Paris to:
expand the phase 2 clinical program of AEF0217 to at least one other type of cognitive
disorders in order to evaluate the full potential of this compound, based on the preliminary
evidence of efficacy of AEF0217 in other cognitive disorders;
to carry out, in parallel with the phase 2b studies of AEF0117 and AEF0217, the addi-
tional clinical and non-clinical developments necessary for these compounds to be ready
to enter phase 3 at the end of phase 2;
to select and introduce a new drug candidate in development to target new brain dis-
eases that involve the CB1 receptor.
The Company could subsequently have recourse to other financing by capital increase and/or
borrowing. In addition, to ensure its financing, the Company may also rely on the payment of the
CIR as well as repayable advances and subsidies that it could request in the future as it has been
able to do in the past.
3.9. Important events since the end of the financial year
3.9.1. Transformation into a public limited company with a Board
of Directors
The General Meeting of January 11, 2022 approved the transformation of the Company into a
public limited company with a Board of Directors, the said transformation taking effect on the
same day.
3.9.2. Modification of the nominal unit value of the Company’s
shares
The General Meeting of January 11, 2022 decided to divide the par value of the shares by 24. It
was thus reduced from €0.096 to €0.004, thus increasing the number of Company shares from
399,698 to 9,592,752.
3.9.3. IPO and capital increase
On February 15, 2022, the Company announced the success of its IPO on compartment B of the
regulated market of Euronext Paris, carried out by way of an open price offer (the "OPO") and of
a global placement (the "Global Placement", together with the OPO, the "Offer"). The Offer price
was set at €14.02 per new ordinary share. 1,822,794 ordinary shares were allocated under the
Offer, representing an amount of 25.55 million. The capital increase of an initial amount of 25
million, i.e. 1,783,167 new shares, has been increased to approximately 25.3 million after partial
exercise of the over-allotment option by issuing 20,691 additional new shares. This last capital
increase was carried out on March 17, 2022, by decision of the Chief Executive Officer acting
within the framework of the sub-delegation, granted by the Board of Directors by its decision
dated February 15, 2022, within the framework of the delegation made to it by the Combined
General Meeting of January 11, 2022.
22
The start of listing on the Euronext market took place on February 18, 2022, after completion of
the capital increase and implementation of settlement-delivery on February 17, 2022.
This IPO also involved:
the conversion into ordinary shares of ABSA B resulting in the cancellation of the BSA
Ratchet 2017 and 2019;
the issue, on the date of completion of the initial public offering, of new ordinary shares,
because of:
the conversion of the Convertible Bonds issued previously (OC2017 and OC2019), for re-
spective amounts of 700,002 and 1,500,022.93 into ordinary shares of the Company. It
was therefore considered that this conversion had no impact on the maturity of the CBs at
the end of the financial year: the 2017 CBs are presented with a maturity of less than one
year and the 2019 CBs are presented with a maturity of one to five years;
the exercise of 600 BSA2019, 2,682 BSA2020, 20 BSPCE2017-1 and 300 BSPCEOCT2020
;
allocation to the issue premium of the costs related to this fundraising, for a total amount
estimated at approximately €2.8 million. In this respect, as at December 31, 2021, the
costs incurred in the 2021 financial year in direct connection with the capital increase dur-
ing the IPO, i.e., €421,293.42, were recognized as prepaid expenses. and will be de-
ducted from the issue premium for the 2022 financial year.
3.9.4. Situation in Ukraine
The conflict initiated in February 2022 between Russia and Ukraine has no direct significant im-
pact on the Company's operational activity, as it has no service provider or ongoing operation in
these two countries.
3.10. Procedures relating to the preparation and processing
of accounting and financial information
The Company has implemented internal control procedures to ensure control of the process for
processing and producing accounting and financial data, including:
clear definition of roles and responsibilities;
separation of functions between operational, control, accounting and payment approval
activities;
application of a strict expenditure commitment authorization process, based on an order
validation circuit with the Director of Operations, Finance and the Managing Director;
verification of each invoice and its merits using a systematic reconciliation with the initial
purchase order (in terms of quantity/service rendered, price, reference) and identification
of the analytical code associated with the budget line;
payment of invoices only when they have been entered and approved beforehand.
Checks prior to payment (list of invoices validated and good to pay, bank details) are car-
ried out by the Financial Director using a transfer proposal drawn up by the accounting
operator;
expenditure commitment procedures systematically include identification of eligibility for
the research tax credit as well as their possible attachment to a specific financing pro-
gram.
23
The Company also relies on the skills of its chartered accountant in the treatment of complex or
new accounting subjects. The latter are also subject, before implementation, to the evaluation by
the auditor.
In addition, the Company has developed approaches based on the identification, anticipation and
monitoring of financial needs using:
a budget process subject to periodic updates, mainly oriented towards cash management
and monitoring of costs on multi-year research and development projects, shared inter-
nally between the various players within the Company;
budget analysis statements showing the progress of expenditure on the various research
and development programs;
cash monitoring tables, drawn up monthly.
These documents are reviewed monthly with the Operations Department and General Manage-
ment. They are regularly supervised by the governance of the Company (board of directors, audit
committee), as described in the paragraph 3.4.1 - Risk management by governance and man-
agement bodies.
3.11. Suggested allocation of the result
It is suggested to approve the annual accounts (balance sheet and income statement) closed on
December 31, 2021 as they are presented and which show a profit of +€3,356,001.
It is suggested:
to allocate the profit for the year in the amount of 3,356,001 to the “Carried forward” ac-
count, the balance of which will thus be brought to a positive balance of 1,507,314; then
to allocate part of the balance of the “Retained earnings” account, namely an amount of
€399.70, to the “Legal reserve” account, which is thus increased from €0 to 399.70; and
to allocate the balance, i.e., €1,507,313.75 to “Other reserves”.
3.12. Non-tax-deductible expenses
In accordance with the provisions of article 223 quater of the General Tax Code, approval is pro-
posed of the expenses and charges referred to in article 39-4 of the General Tax Code (non-tax
deductible charges) amounting to a total amount of €27,531 related to the tax reintegration of part
of the expenses relating to directors' fees in application of the regulations in force.
It is also specified that in the accounts closed on December 31, 2021 the non-tax deductible ex-
penses (not covered by article 39-4 of the CGI) amount to €0.
3.13. Past dividend distributions
In order to comply with the provisions of article 243 bis of the General Tax Code, it is reminded
that no dividend distribution has been made since the incorporation of the Company.
24
3.14. Information on supplier and customer payment terms
Pursuant to Articles L. 441-6-1 and D. 441-4 of the Commercial Code, the information relating to
payment terms for suppliers and customers defined by the decree of March 20, 2017 is as fol-
lows:
ARTICLE D. 441 I. - 1° OF THE FRENCH COMMERCIAL CODE: INVOICES RECEIVED AND NOT PAID ON
THE CLOSING DATE OF THE FINANCIAL YEAR WHOSE TERM HAS EXPIRED
91
Total
(1 day
and
1 to
30
days
31 to
60
days
61 to
90
days
0 day
(indicative)
days
and
more
Invoice analysis
more)
(A) Late payment tranche
4
4
-
-
-
-
-
-
4
Number of invoices concerned
Total amount of invoices concerned
including VAT
28,011
32,708
32,708
Percentage of the total amount of
purchases for the financial year in-
cluding tax
0.60%
0.70%
0.70%
(B) Invoices excluded from (A) relating to disputed or unrecognized payables and receivables
Number of invoices excluded
-
-
-
-
4
-
-
4
8
Total amount of invoices excluded
including tax
9,751
61,037
70,788
(C) Benchmark payment terms used (contractual or legal deadline - article L. 441-6 or article L. 443-1 of the
Commercial Code)
Payment terms used for the calcula-
Legal Deadline
tion of late payments
Customer payment term
All invoices issued were paid on the closing date.
3.15. Employee participation in the capital at the end of
financial year
The share of the Company's capital held by employees exceeds 3%. The Company has not set
up a company savings plan.
25
3.16. Summary statement of transactions by managers and
persons mentioned in Article L. 621-18-2 of the
Monetary and Financial Code on Company securities
carried out during the past financial year
3.16.1. Continuation of agreements and commitments entered into
during a previous financial year
No agreement concluded for the 2020 financial year continued during the 2021 financial year. In-
deed, all the contracts concluded with the directors are without tacit renewal and are therefore re-
approved annually.
3.16.2. Agreements and commitments entered into during the 2021
financial year
3.16.2.1.With Mr. François Thomas, member of the Board of Directors
The Board of Directors, in its meeting of February 24, 2021, authorized the Company to renew
the consultancy contract with the company Thomas Conseil SPRL, of which Mr. François
Thomas is the Chairman. The purpose of the contract is to provide assistance to the Company in
the search for dilutive and non-dilutive financing, and assistance in negotiation. The contract runs
from January 1 to December 31, 2021, without tacit renewal.
This agreement was established in order to allow the Company to benefit from the resources and
means necessary to seek possible additional financing.
The compensation of Thomas Conseil SPRL, initially set at 15,000 excluding tax, was revised
on July 19, 2021 and was set at 20,000 excluding tax for the 2021 financial year.
Under this contract, the expense for the year thus amounted to 20,000.
3.16.2.2.With Mr. Anders Gersel, Chairman of the Board of Directors
The Board of Directors, in its meeting of February 24, 2021, authorized the Company to enter into
a consultancy contract with the company Gerselconsult Aps, of which Mr. Anders Gersel is the
Chairman. The purpose of the contract was to provide assistance to the Company in terms of
clinical studies, regulatory procedures, search for industrial and financial partners, and assistance
in negotiating contracts.
It was terminated by decision of the Board of Directors on October 14, 2021, with retroactive ef-
fect from January 1, 2021. No compensation was paid in 2021 under this contract.
In accordance with Article L. 227-10 of the French Commercial Code, these agreements have
been communicated to the Statutory Auditor.
26
3.17. Acquisition of significant holdings in companies
having their registered office in France, or takeover of
such companies; disposals of such interests
No equity participation or control is to be reported. It is recalled that the Company does not hold
any shareholdings.
3.18. Information relating to the distribution of capital and
treasury stock Share buyback program
The table below shows the percentage of capital and voting rights at the end of the 2021 financial
year. The number of shares and voting rights indicated below, however, takes into account the
division of the nominal by 24 approved by the General Meeting of shareholders dated January
11, 2022, concomitantly with the transformation of the Company into a public limited company.
27
BREAKDOWN OF THE CAPITAL AND VOTING RIGHTS OF THE COMPANY AS OF DECEMBER 31, 2021
AFTER TAKING INTO ACCOUNT THE DIVISION BY 24 OF THE PAR AUTHORIZED BY THE GENERAL
MEETING OF JANUARY 11, 2022
Distribution of share capital and voting rights Distribution of share capital and voting rights on
on a non-diluted basis
a fully diluted basis (4)
Theoreti-
cal % of Number of
Theoreti-
cal % of
voting rights voting
rights
Shareholders
% of
Number of
share
Theoretical
voting
rights
% of
share
capital
Theoretical
shares
voting
rights
shares
capital
Pier Vincenzo
Piazza (Chief
Executive Officer)
Anders Gersel
Pedersen
2,083,200
21.72%
2,083,200
21.72%
2,664,000
21.76%
0.78%
2,664,000
21.76%
-
-
-
-
96,000
96,000
0.78%
(Chairman of the
Board of Directors)
Total individual
executive officers
2,083,200
21.72%
2,083,200
21.72%
2,760,000
22.54 %
2,760,000
22.54%
Inserm Transfert
Initiative
1,487,040
15.50%
1,487,040
15.50%
1,568,784
12.82%
1,568,784
12.82%
Nouvelle-Aquitaine
Co-investissement
(1)(5)
924,432
302,400
286,032
9.64%
3.15%
2.98%
924,432
302,400
286,032
9.64%
3.15%
2.98%
924,432
302,400
7.55%
2.47%
9.60%
924,432
302,400
7.55%
2.47%
9.60%
Aqui-Invest (1)(5)
Nouvelle-Aquitaine
Region (5)
1,174,872
1,174,872
Aquitaine Création
Investissement (1)
562,896
745,680
5.87%
7.77%
562,896
745,680
5.87%
7.77%
562,896
745,680
4.60%
6.09%
562,896
745,680
4.60%
6.09%
Aelis Innovation (2)
FPS Bpifrance In-
novation I (3)
1,798,440
18.65%
1,789,440
18.65%
1,789,440
14.62%
1,789,440
14.62%
Total Investors
6,097,920
63.57%
6,097,920
63.57%
7,068,504
57.73%
7,068,504
57.73%
Founders-manag-
ers / managers
who are not cor-
porate officers
Total employees,
consultants and
individual non-ex-
ecutive directors
Other individual
founder share-
holders
586,032
6.11%
586,032
6.11%
1,125,336
9.19%
6.66%
1,125,336
9.19%
350,400
475,200
3.65%
4.95%
350,400
475,200
3.65%
4.95%
815,208
475,200
815,208
475,200
6.66%
3.88%
3.88%
Total
9,592,752 100.00% 9,592,752 100.00% 12,244,248
100.00%
12,244,248 100.00%
(1) It is specified that the Company Aquiti Gestion has a management mandate for the Aquitaine Création Inves-
tissement fund (a private investment structure in which the Nouvelle-Aquitaine Region is a 30% shareholder), and
an advisory mandate for the Aqui-Invest and Nouvelle-Aquitaine Co-Investissement.
(2) The Aelis Innovation fund is represented by the management Company, Irdi Capital Investissement.
(3) The FPS Bpifrance Innovation I fund is represented by the management Company, Bpifrance Investissement.
(4) The fully diluted base comprises (i) founders’ share warrants (BSPCEs) issued between 2017 and 2021, (ii)
share warrants (BSAs) issued between 2013 and 2021, and convertible bonds issued in 2017 and 2019.
(5) The sub-total of the Company’s capital held by the Nouvelle-Aquitaine Region and by funds that have a capital
link with the Nouvelle-Aquitaine Region: (i) the percentage of capital and voting rights on a non-diluted basis: 9.3%;
(ii) the percentage of capital and voting rights on a fully diluted basis: 15.02%.
A table presenting the Company's shareholding at the date of this Report is provided in Section
4.9.
The Company did not undertake a share buyback program in 2021.
28
3.19. Changes occurring during the financial year in the
composition of the capital
During the 2021 financial year, 218 BSAs were exercised and gave rise to a capital increase of
€2.18 (218 shares with a par value of €0.01).
3.20. Share price progression
As the listing on compartment B of the Euronext Paris regulated market took place on February
18, 2022, i.e. after the closing date, this point is not applicable for the 2021 financial year.
3.21. Information relating to allocations of share
subscriptions or purchase options and free share
allocations
The table below details the BSA and BSPCE allocation programs and the outstanding warrants
for the 2021 financial year.
DETAILS OF THE BSA AND BSPCE ALLOCATION PROGRAMS
Maximum
number of
shares that
Number of outstanding warrants
Grant
Date
Type
12/31/20 Granted
Exercised Obsolete 06/30/21 can be
subscribed for
BSA
12/19/13
06/27/18
12/18/18
03/19/19
10/23/20
04/29/21
06/13/17
06/27/18
03/04/19
315
800
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
315
800
31,500
BSA 2017
BSA 2018
BSA 2019
BSA 2020
BSA 2021
BSPCE
-
800
150
150
-
150
600
-
600
600
2,400
-
-
2,400
1,500
20
2,400
1,500
2,000
15,000
3,917
6,200
4,400
1,789
70,256
1,500
20
-
BSPCE 2017
BSPCE 2019
15,000
3,917
6,200
4,400
-
-
15,000
3,917
6,200
4,400
1,789
37,091
-
BSPCE 02.2020 02/21/20
BSPCE 10.2020 10/21/20
-
-
BSPCE 2021
04/29/21
1,789
3,289
TOTAL
33,802
(*) Amount taking into account the division by 24 of the nominal voted by the Combined General Meeting of January
11, 2022.
29
3.22. Table of results for the past 5 years
INFORMATION ON THE RESULTS FOR THE PAST 5 YEARS
Type of information
(in euros)
12/31/2017 12/31/2018 12/31/2019 12/31/2020
12/31/2021
I. Capital at the end of the financial year
a) Share capital
2,925
3,627
3,995
3,995
3,997
b) Number of shares issued
294,549
14,900
362,652
399,480
399,480
399,698
c) Number of bonds convertible
into shares
14,900
40,441
40,441
40,441
II. Operating revenue and operation income
a) Revenue excluding tax
85,472
39,959
(3,474,388)
938,132
(2,540,554)
-
8,851
(3,701,755)
790,739
(2,918,550)
-
-
9,075,395
2,479,830
890,786
3,356,001
-
b) Profit before tax, depreciation
and provisions
(2,004,470)
1,002,929
(1,002,795)
-
(3,466,893)
691,703
(2,783,646)
-
c) Income taxes
d) Profit after tax, depreciation and
provisions
e) Amount of profits distributed
III. Earnings per share
a) Profit after tax, but before de-
preciation and provisions
(4.77)
(8.37)
(7.85)
(6.95)
8.44
b) Profit after tax, depreciation and
provisions
(4.78)
-
(8.38)
-
(7.87)
-
(6.97)
-
8.40
-
c) Dividend paid for each share
IV. - Staff
a) Number of employees (average
workforce)
8
9
11
10
14
b) Payroll amount
555,309
150,224
772,169
208,239
1,107,363
298,870
1,163,595
304,820
1,518,698
571,085
c) Amount paid for social benefits
(social security, works, etc.)
30
Section 4 - Report on Corporate Governance
4.1. Corporate Governance code
The Company refers to the Corporate Governance Code for midcaps and small caps as updated
in September 2021 by MiddleNext (the “MiddleNext Code”) as its reference code from the admis-
sion of its shares to the Euronext Paris regulated market.
The Company does not currently comply with all the recommendations of the MiddleNext Code
but has the objective of doing so. The table below lists the various recommendations of this Code
and specifies those with which the Company will or will not comply.
MIDDLENEXT CORPORATE GOVERNANCE CODE RECOMMENDATIONS
Company
does not
comply
Company
complies
Upcoming
compliance
Category of recommandation
“Supervisory” authority
R1 - Conduct of the members of the board
X
X
R2 - Conflicts of interest
R3 - Composition of the board - Presence of independ-
ent members
X
X
R4 - Information to be provided to members of the
board
X (1)
R5 - Training to be provided to members of the board
R6 - Organization of board and committee meetings
R7 - Establishment of committees
X
X
R8 - Establishment of a specialist corporate social re-
sponsibility (CSR) committee
X (2)
R9 - Adoption of rules of procedure for the board
R10 Choice of each director
X
X
R11 - Terms of office of board members
R12 - Compensation of members of the board
R13 - Evaluation of the work carried out by the board
R14 - Relations with shareholders
X (3)
X
X (4)
X (5)
R15 - Diversity and gender equality policy at the Com-
pany
X (6)
Executive authority
31
R16 - Definition and transparency of the compensation
of executive officers
X
R17 - Preparations for the succession of executive
management
X (7)
R18 - Officers with employment contracts
R19 - Severance pay
N/A
X (8)
N/A
R20 - Supplementary pension plans
R21 - Stock options and bonus shares
R22 - Review of key areas of concern
X (9)
X
(1) The Company plans to set up a three-year training program for its directors during the 2022 financial year in
accordance with the recommendations of the MiddleNext Code.
(2) the CSR Committee is integrated into the Remuneration and Appointments Committee.
(3) It is specified that all the directors of the Board of Directors were simultaneously appointed as directors of the
limited company by the General Meeting of shareholders on January 11, 2022. In addition, the Company's articles
of association provide, since the admission of the Company's shares to trading on the Euronext Paris market,
that, as an exception to the normal term of office of director of three (3) years and in order to allow exclusively the
implementation or maintenance of the staggered terms of directors, the Ordinary General Meeting of the Com-
pany may appoint one or more members of the Board for a term of two (2) years or one (1) year. To date, the
terms of office of the members of the Board of Directors are therefore not staggered.
(4) This recommendation provides that once a year, the Chairman of the Board invites the members to express
their views on the functioning of the Board, any Committees, as well as on the preparation of its work. This dis-
cussion is recorded in the minutes of the meeting. The chairman reports in his report that this procedure has
taken place. This recommendation has been implemented by the Company.
(5) This recommendation provides that, outside the General Meeting, moments of discussion with significant
shareholders be organized in such a way as to establish the conditions for a fruitful dialogue. Prior to the General
Meeting, the manager or the person(s) in charge of financial communication ensures that they meet the signifi-
cant shareholders who so wish. The Board of Directors will also pay particular attention to negative votes by ana-
lyzing, among other things, how the majority of minority shareholders expressed themselves. This person will
need to consider what may need to change, with a view to the next General Meeting, in to negative votes and
about the possibility of a announcement on this subject. This recommendation will be implemented within the
framework of future board meetings which will take place from the date of the aforementioned General Meeting.
(6) The Company plans to implement a policy aimed at gender balance and equity in accordance with the recom-
mendations of the MiddleNext Code during the first half of 2022, and will report on the implementation, or not, of
each new recommendation, as part of the next Corporate Governance Report. The Board of Directors of the
Company at the date of writing this report on corporate governance has 3 female directors, 3 directors and a non-
voting member.
On the closing date of the accounts closed on December 31, 2021, out of 26 employees (23 employees and 3
full-time equivalent consultants), the Company has 17 women, i.e. 65% of the workforce.
(7) The choice was made to separate the functions of Chairman of the Board of Directors and Chief Executive
Officer.
(8) The severance pay for the Chief Executive Officer amounts to 6 months of gross compensation (which in-
cludes fixed, variable and exceptional compensation if applicable) and would be due in the event of termination of
his duties resulting from a decision of the Board of Directors.
(9) No performance condition is currently envisaged for the exercise of all or part of the stock options or the defini-
tive allocation of all or part of the free shares. The loyalty criterion is considered essential by the Company, which
does not plan to derogate from it for future allocations.
4.2. Corporate governance
4.2.1. Board of Directors in 2021
Aelis Farma was a Company in the form of a simplified joint stock company (SAS) until January
11, 2022. Prior to this date, due to the choice of governance put in place by the Company and its
32
shareholders, a statutory board of directors as well as audit and compensation committees within
it had been set up, and included independent directors.
The composition of the Board of Directors in 2021 was as follows:
Chairman of the Board: Anders Gersel Pedersen (Independent Director)
Pier Vincenzo Piazza, Chairman of the SAS
Inserm Transfert Initiative, represented by François Thomas,
Alain Sainsot, Independent Director,
Thibaut Richebois, representative of the NACO and Aqui Invest regional funds
The Nouvelle-Aquitaine Region, represented by Brahim Guetarni (appointed at the Gen-
eral Assembly of July 2021)
Aelis Innovation, represented by Benedikt Timmerman, censor.
4.2.2. Changes in the composition of the Board of Directors
The composition of Aelis Farma Board of Directors has changed:
as of January 11, 2022 as part of the transformation of the Company into a limited com-
pany with a Board of Directors. The shareholders of the Company have opted for the sep-
aration of functions between Chairman and Chief Executive Officer.
Alongside Anders Gersel Pedersen, Pier Vincenzo Piazza and the Nouvelle-Aquitaine
Region, represented by Mr. Brahim Guetarni, three new directors, Karina Hansen, Karen
Linehan and Irina Staatz-Granzer, have been appointed as of the General Meeting of
Partners on January 11, 2022 and qualified as independent by the Board of Directors.
Similarly, Inserm Transfert Initiative, represented by Mr. François Thomas, until then di-
rector, was appointed censor on the same date. Finally, Irdi Capital Investissement, rep-
resented by Mr. Benedikt Timmerman, and Mr. Thibaut Richebois were also appointed
censors.
as of the date of the listing of the Company on the regulated market of Euronext Paris:
Irdi Capital Investissement and Mr. Thibaut Richebois, who had undertaken with the
Chairman of the Board of Directors to resign from their functions within the Board of Di-
rectors subject to the listing of the Company on the regulated market of Euronext Paris,
from the first day of trading in the Company's shares, resigned from the Company on
February 18, 2022.
4.2.3. Presentation of the members of the Board of Directors, and
its committees at the date of closing of the accounts
On the closing date of the financial statements for the year ended December 31, 2021, the Board
of Directors had 7 members (including 6 directors and a non-voting member). Among the 6 direc-
tors, 2 are considered by the Board of Directors as having the status of independent directors
with regard to the conditions defined by the MiddleNext Code.
As of January 11, 2022, the Company has 6 directors and one censor. Among the 6 directors, 4
are considered by the Board of Directors as having the status of independent directors with re-
gard to the conditions defined by the MiddleNext Code.
33
All members of the Board of Directors are professionally domiciled at the Company's registered
office, i.e. at 146 rue Léo Saignat Institut François Magendie 33000 Bordeaux.
The table below and the biographies that follow only present the 7 members (6 directors and a
non-voting member) who, following the listing of the Company's shares on the regulated market
of Euronext Paris, make up the Board of Directors of the Company on the date of the Board of
Directors' approval of the financial statements for the financial year ended December 31, 2021.
COMPOSITION OF THE BOARD OF DIRECTORS
Appointments,
compensation
Committee and CSR
committee
Surname, first
name, title or role
of directors
Indepen-
dent
director
Year of first
appointment
Expiry of term
of office
Audit
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
Anders Gersel Peder-
sen, Chairman of the
Board of Directors
Yes
Yes
Yes
No
2020*
2017*
Chairman
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
Pier Vincenzo Piazza,
CEO and director
No
Yes
No
No
No
Nouvelle-Aquitaine
Region, represented
by Brahim Guetarni,
Director
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
No
2021*
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
Karina Hansen,
Director
Yes
Yes
Yes
2022
2022
2022
Yes
Yes
No
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
Karen Linehan,
Director
Yes
Chairman
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
Irina Staatz-Granzer,
Director
No
Inserm Transfert
Initiative,
represented by
François Thomas,
Observer**
At the end of the an-
nual AGM ruling on
the accounts closed
on 12/31/2024
No
2022
Yes
No
* These dates correspond to the dates of appointment to the Board of Directors of the Company before its conver-
sion into a limited company, as decided by the general meeting of January 11, 2022. At the general meeting of Jan-
uary 11 2022 all the members of the Board of Directors mentioned in the table above were appointed to the Board
of Directors of the Company as of its conversion into a limited company.
** Prior to its appointment as an observer on January 11, 2022, Inserm Transfert Initiative, represented by François
Thomas, had held the position of director of the Company since 2018.
4.2.4. Biographies of members of the Board of Directors
Anders Gersel Pedersen, Chairman of the Board of Directors, Danish
Anders Gersel Pedersen was born in 1951 and received his medical degree and doctoral degree
in medical sciences from Copenhagen University and an undergraduate degree from Copenha-
gen Business School. He then worked for Eli Lilly for 11 years, 10 of which as a director oversee-
ing worldwide clinical research in oncology. In 2000, he joined the Lundbeck group (a
34
pharmaceutical Company that is focused exclusively on brain diseases) as Vice-President of In-
ternational Clinical Research. He was then appointed Executive Vice-President of Drug Develop-
ment and, in 2011, was appointed head of all Research and Development activities at Lundbeck.
Anders Gersel Pedersen is also Vice-Chairman of Bavarian Nordic A/S and a board member of a
number of scientific societies, including: Fonden Lundbeck International Neuroscience Founda-
tion (Chairman), the Danish Society for Medical Oncology, the Danish Society for Internal Medi-
cine, the International Association for the Study of Lung Cancer, the European Society for Medi-
cal Oncology and the American Society of Clinical Oncology.
Pier Vincenzo Piazza, Director and Chief Executive Officer, French
Pier Vincenzo Piazza was born in 1961 and is an entrepreneur and renowned scientist who has
been involved in establishing biotech companies and academic research institutes. He obtained
his medical degree with distinction in 1985 from the Faculty of Medicine of the University of Pa-
lermo (Italy), where he also obtained a PhD in neuroscience in 1991. He founded and managed
INSERM's Neurocentre Magendie for 10 years (2007-2017), and published numerous scientific
articles in prestigious journals (Science and Nature), and his research has to date received more
significant contribution is to the understanding of the mechanisms of behavioral pathologies,
which led to the discovery of CB1-SSi. For this discovery, he received the Grand Prix de Neurolo-
gie de l’Académie des Sciences and the INSERM Grand Prix in 2015, the most prestigious
French awards in the field of neurology and medicine. In 2013, he co-founded Aelis Farma and
was initially its Chief Scientific Officer, before becoming Chairman and Chief Executive Officer in
December 2017. Under his management, Aelis Farma has brought two drug candidates to clinical
trials, secured the financing required by its development programs, established a network of lead-
ing international partners (Columbia University, Yale, NIH-NIDA and IMIM) and secured a major
industrial partnership.
Nouvelle-Aquitaine Region, represented by Brahim Guetarni, Director, French
Brahim Guetarni was born in 1971 and holds a master’s in law and a master’s in business admin-
istration from the University of Limoges. In 2005, he was appointed a project manager by the Li-
mousin Region, a role that he carried out for 9 years. He then joined the Nouvelle-Aquitaine Re-
gion in 2015 as a project manager, before being appointed Deputy Secretary and Head of Finan-
cial Engineering (Economic Development Division).
Karina Hansen, Director, Danish
Karina Hansen, born in 1973, is a health economist with a doctorate in health economics from the
University of Paris-Sud, France, and a master's degree in economics from the University of Co-
penhagen in Denmark. Karina Hansen is Executive Director of the Center of Expertise in Health
Economics within Global HEOR (Health Economics and Outcomes Research) at AbbVie. In addi-
tion, she has held various senior HEOR international positions at Allergan and previously worked
at Lundbeck for over 18 years as Vice President of Global Health Economics and Epidemiology,
as well as other positions such as Division Director of HTA (Health Technology Assessment)
Management, Director of Global HEOR, Director of Global Market Access. Her area of expertise
lies in research on health economics outcomes, real-world evidence and market access, with par-
ticular emphasis on translating and complementing development and R&D strategy with HEOR
and RWE (Real-World Evidence) studies, economic models and comparative efficiency solutions
to ensure optimal assessment of health technologies (HTA) worldwide. Her areas of therapeutic
35
expertise include neuroscience, eye care, gastroenterology and women's health. Karen Hansen
is a peer reviewer of scientific journals within HEOR and a member of several scientific societies.
Karen Linehan, Director, Danish
Karen Linehan was born in 1959. She holds a BA in American Studies and a Juris Doctorate from
Georgetown University in the United States. Prior to practicing law, Karen Linehan started out as
an attaché in the office of the Speaker of the US House of Representatives from September 1977
to August 1986. Until December 1990 she was a partner in a medium-sized law firm in New York.
In January 1991, she joined Sanofi, a global healthcare Company, as Deputy Legal Director of
the American subsidiary. Karen then moved to Paris in July 1996 to handle Sanofi's international
legal affairs and held various positions within the legal department, including that of deputy direc-
tor of legal operations. From March 2007 until her retirement on December 31, 2021, she was Ex-
ecutive Vice President and General Counsel of Sanofi. Karen was also a member of Sanofi’s Ex-
ecutive Committee, a member of the Board of Directors of several Sanofi subsidiaries, and a
founding member of the Sanofi Gender Balance Board.
Irina Staatz-Granzer, Director, German
Irina Staatz-Granzer was born in 1960 and has a doctorate in pharmacy from the Philipps-Univer-
sität Marburg and the University of Tübingen University (Germany). She has held positions in
business development for several pharmaceutical and biotechnology companies, notably in busi-
ness development at Hermal (a subsidiary of Merck KGaA), Boots Healthcare International, Knoll
(BASF Pharma, then Abbott), and as CEO of Scil Technology GmbH, CEO of U3 Pharma AG
and President of Blink SAS biomedical. She is also President of the German Pharmaceutical Li-
cense Club (PLCD). She founded and currently heads the Staatz Business Development & Strat-
egy consultancy. Dr Staatz-Granzer is also Chairwoman of Emergence Therapeutics AG and
Vice Chairwoman of the Supervisory Board of Innate Pharma, a role she has held since 2009.
Inserm Transfert Initiative, represented by François Thomas, Observer, French
Inserm Transfert Initiative (ITI) is a French investment company, based in Paris, specializing in
seed funding for early-stage life sciences companies and in particular spin-offs from large French
academic research centers.
François Thomas was born in 1957 and is a medical oncologist (Paris Faculty of Medecine), a
former clinical head at Gustave Roussy, and holds an MBA from the Massachusetts Institute of
Technology. He is currently operating partner for health at Quadrille Capital. He was Chairman of
the Inserm Transfert Initiative (ITI) fund, one of the first financial investors in Aelis Farma. He has
also previously held the positions of Vice-President of Clinical Development at Ipsen, Manager at
Bioserve Ltd Consulting, Director of Development and Medical Affairs at Genset and Chief Exec-
utive Officer of Cythéris. He was also a partner at Atlas Venture and head of the healthcare cor-
porate finance business at Bryan Garnier (investment bank). François Thomas has been a mem-
ber of the Boards of Directors of more than 20 biotech companies in the EU and North America.
4.2.5. Independent members of the Board of Directors
With regard to the independence criteria defined by recommendation no. 3 of the MiddleNext
Code, the Board of Directors considered that 4 members of the Board of Directors, Anders Gersel
Pedersen and Karina Hansen, Karen Linehan and Irina Staatz- Granzer, are independent direc-
tors on the Board of Directors.
36
THE COMPANY’S ANALYSIS OF THE INDEPENDENCE CRITERIA SET OUT IN THE MIDDLENEXT CODE
Must not have
been, in the
last two years,
Must not have
been, in the
last five years, material busi-
and must not
be an em-
ployee or ex-
ecutive officer
of the Com-
pany
and must not
be party to any
Must not have
a close rela-
tionship or
close family
ties with a
Company of-
ficer or refer-
ence share-
holder
Must not be a
reference
Must not have
been, in the
last six years,
the Com-
shareholder in
the Company
or hold a sig-
nificant per-
centage of its
voting rights
Members of
the Board of
Directors
ness relation-
ship with the
Company (as a
customer,
supplier, com-
petitor, service
provider, cred-
itor or banker,
etc.)
pany’s auditor
Anders Gersel
Pedersen (1)
Karina Hansen
Board Director
Karen Linehan
Board Director
Irina Staatz-
Granzer
Board Director
(1) Anders Gersel Pedersen owns 4,000 founders’ share warrants (BSPCEs), representing 0.78% of the fully
diluted capital of the Company.
Furthermore, Gerselconsult ApS, whose Chief Executive Officer is Anders Gersel Pedersen, en-
tered into a consultancy agreement with the Company on February 18, 2020. This agreement, as
amended, was terminated with effect from January 1, 2021 and was not in effect in this financial
year.
The annual fee under the aforementioned consultancy agreement was capped at €35,000. Since
this amount was not considered to be “material” either for Anders Gersel Pedersen or for the
Company, the Company considers that Anders Gersel Pedersen has not, in the most recent two
years, had a material business relationship with the Company and may be classified as an inde-
pendent director for the purposes of the MiddleNext Code.
It is also specified that on a diluted basis, the percentage of capital and voting rights that would
result from the exercise by Mr. Gersel Pedersen of the BSPCEs held by him, i.e. 0.78% on the
date of this Report, remains limited.
The Board of Directors appointed by the shareholders at the General Meeting held on 11 Janu-
ary, 2022, at which the shareholders resolved to convert the Company into a société anonyme
(public limited company), has confirmed, based on the criteria set out in recommendation 3 in the
table above that 4 of its members (Anders Gersel Pedersen, Irina Staatz-Granzer, Karen
Linehan, and Karina Hansen) may be classified as independent members. There are no close
family ties between the directors.
37
4.2.6. External roles held by directors of the Company
CURRENT EXTERNAL ROLES OF DIRECTORS OF THE COMPANY
Name and position
Relevant companies
Nature of the position(s)
Anders Gersel Pedersen,
Chairman of the board
of directors
Genmab
Director
Director
Director
Director
Hansa Medical AB
Bond Avillion 2
Bavarian Nordic A/S
Pier Vincenzo Piazza,
Chief Executive Officer and
director
None
None
Brahim Guetarni,
Director
None
None
Karina HA Hansen,
Director
AbbVie
Executive Director, Head of Center of
Expertise of Health Economics,
Global HEOR
Karen Linehan,
Director
Veon Ltd.
Independent Director
Member of the Audit & Risk Commit-
tee and the Nominating & Corporate
Governance Committee
Global Antibiotic R&D Partnership
(GARDP), North America
Independent Director
Irina Staatz,
Director
Staatz Business Development &
Strategy
Founder and CEO
Innate Pharma SA
Vice Chairman and member of the
Supervisory Board
Chairman
Emergence Therapeutics AG
PLCD (German Pharma Licensing
Club)
Chairman
François Thomas,
Representing Inserm
Transfert Initiative
Observer
BergenBio
Integragen
Gamamabs
Cardiawave
Biomodex
Director
Director
Director
Director
Director
38
EXTERNAL ROLES AND PRINCIPAL ACTIVITIES UNDERTAKEN DURING THE PAST FIVE YEARS WHICH
HAVE CEASED
Nature of the position(s) and/or
principal activities
Name and position
Relevant companies
Anders Gersel Pedersen,
Chairman of the board of
directors
Lundbeck
Executive Vice-President with responsibility
for Research and Development activities
Pier Vincenzo Piazza,
Chief Executive Officer
and director
None
None
None
Brahim Guetarni,
Director
None
Karina HA Hansen,
Director
Allergan
Executive Director of International Health
Economics & Outcomes Research, Global
HEOR
Lundbeck
Lundbeck
VP of Health Economics & Epidemiology
Division
Divisional Director of Health Economics &
HTA Management Division, Global
Outcomes Research
Karen Linehan,
Director
Sanofi
Sanofi
Executive Vice President and General
Counsel Responsible for Legal, Ethics &
Business Integrity
Member of the Executive Committee
beneath the CEO
EuroApi and Sanofi Aventis
Deutschland GmbH
Supervisory Board Member
Irina Staatz,
Director
Talix Therapeutics NV
Blink Biomedical SAS
Blink Therapeutics Ltd
Chairman
Chairman
Chairman
François Thomas,
Representing Inserm
Transfert Initiative
Bioaxial
Director
Director
Director
Director
Director
Director
Sensorion
Enyo Pharma
Eyevensys
Step Pharma
Therachon
4.2.7. Agreements between a corporate officer or shareholder
holding at least 10% of the voting rights of a company and
another controlled by the former within the meaning of
Article L. 233-3 of the French Commercial Code
There is no other agreement with a corporate officer or a shareholder holding at least 10% of the
voting rights, apart from those described in paragraph 3.16 - Summary statement of the opera-
tions of the managers and the persons mentioned in article L. 621 -18-2 of the Monetary and Fi-
nancial Code on Company shares made during the past financial year.
39
4.2.8. Summary table of currently valid financial delegations and
showing the use made of these delegations during the
financial year
The currently valid financial delegations were adopted by the general meeting of shareholders of
the Company on January 11, 2022. Consequently, the table presented below shows the currently
valid delegations and the use that has been made of them in 2022 since this date:
SUMMARY TABLE OF CURRENTLY VALID FINANCIAL DELEGATIONS
Price
Date and terms of use
by the Board
Purpose of the
resolution
Duration Ceilings
determination
methods
of
Directors
Authorization to be given to
the Board of Directors for the
purchase by the Company of
its own shares (22nd resolu-
tion of the AGM of January
11, 2022)
18 months
Maximum purchase price
per share: 42.06
-
Buyback program adopted on
February 15, 2022 and Li-
quidity contract implemented
as of March 18, 2022
Overall ceiling of
10,000,000
10% of the amount of share
capital
Authorization to be given to
the Board of Directors to re-
duce the share capital by
canceling shares within the
framework of the authoriza-
tion to buy back its own
18 months
Maximum purchase price
per share: 42.06
-
Not used
Cancellation within the
maximum limit of 10% of
the amount of the share
capital per period of 24
months
shares (23rd resolution of the
AGM of January 11, 2022)
Delegation of authority to the
Board of Directors to increase
the share capital by issuing
ordinary shares and/or other
securities, without sharehold-
ers' preferential subscription
rights, by means of a public
offering other than those re-
ferred to in Article L. 411-2 1°
of the Monetary and Financial
Code (24th resolution of the
AGM of January 11, 2022).
26 months
80% of the share capital on
the date of the capital in-
crease decision by the
Board of Directors (2)
Refer to (1)
18.59% of the share capital
as of February 15, 2022 was
used in the context of the is-
sue on the same day of new
shares on the occasion of the
IPO (Open Price Offer and
Placement global IPO)
Delegation of authority to be
granted to the Board of Direc-
tors with a view to increasing
the capital by issuing ordinary
shares and/or any securities
which are capital securities
giving access to other capital
securities or giving right to the
allocation of debt securities,
and/or securities giving ac-
cess to equity securities to be
issued, with maintenance of
shareholders' preferential
subscription rights (26th reso-
lution of the AGM of 11 Janu-
ary 2022)
26 months
100% of the share capital
on the date of the capital in- the Board of Direc-
crease decision by the
Board of Directors (1)
At the discretion of
Not used
tors
40
Price
Date and terms of use
by the Board
Purpose of the
resolution
Duration Ceilings
determination
methods
of
Directors
Delegation of authority to be
granted to the Board of
26 months
Within the limit of 20% of
the share capital per period
of 12 months (2)
Refer to (3)
Not used
Directors with a view to in-
creasing the capital by issu-
ing ordinary shares and/or
any transferable securities
which are capital securities
giving access to other capital
securities or giving right to al-
location of debt securities
and/or securities giving ac-
cess to equity securities to be
issued, with cancellation of
shareholders' preferential
subscription rights to be is-
sued as part of an offer for
the benefit of qualified inves-
tors or a restricted circle of in-
vestors referred to in 1° of ar-
ticle L.411-2 of the monetary
and financial code
(26th resolution of the AGM
of January 11, 2022)
Delegation of authority to be
granted to the Board of Direc-
tors with a view to increasing
the capital by issuing ordinary
shares and/or any securities
which are capital securities
giving access to other capital
securities or giving right to the
allocation of debt securities
and/or securities giving ac-
cess to equity securities to be
issued with cancellation of
shareholders' preferential
18 months
80% of the share capital on
the date of the capital in-
crease decision by the
Board of Directors (1)
Refer to (4)
Not used
subscription rights in favor of
categories of persons sounds
meeting specific characteris-
tics (27th resolution of the
AGM of January 11, 2022)
Delegation of authority to the
Board of Directors to increase
the number of shares to be is-
sued in the event of a capital
increase with or without pref-
erential subscription rights
(28th resolution of the AGM
of January 11, 2022)
26 months
Within the limit of 15% of
the initial issue (1)
Same price as the
original issue
Used on 17 March 2022 for
1.16% (i.e. 20,691 new
shares) of the issue carried
out on February 17, 2022 as
part of the IPO following the
partial exercise of the over-al-
lotment option
Authorization to the Board of
Directors, in the event of the
issue of shares or any securi-
ties with cancellation of
26 months
Within the limit of 10% of
the share capital
Refer to (5)
Not used
shareholders' preferential
subscription rights, to set the
issue price within the annual
limit of 10% share capital and
within the limits set by the
General Meeting (29th resolu-
tion of the AGM of January
11, 2022)
41
Price
Date and terms of use
by the Board
Purpose of the
resolution
Duration Ceilings
determination
methods
of
Directors
Delegation of authority
26 months
Capital increase: 10% of
Not used
granted to the Board of Direc-
tors to issue ordinary shares
and securities giving access
to the capital of the Company,
in the event of a public offer
comprising a component of
exchange initiated by the
Company (30th resolution of
the AGM of January 11,
2022)
the share capital as it exists
on the date of the transac-
tion in question (1)
Debt securities:
50,000,000
Delegation of power to grant
to the Board of Directors for
the purpose of deciding to is-
sue ordinary shares of the
Company or securities giving
access by any means, imme-
diately and/or in the future, to
ordinary shares of the Com-
pany, within the limit of 10%
of the capital, to remunerate
contributions in kind of capital
securities or transferable se-
curities giving access to the
capital of third-party compa-
nies outside of a public ex-
change offer (31st resolution
of the AGM of 11 January
2022)
26 months
Within the limit of 10% of
the share capital as it exists
on the date of the transac-
tion in question (1)
-
Not used
Delegation of authority to be
granted to the Board of Direc-
tors to decide on any merger-
absorption, demerger or par-
tial contribution of assets
(32nd resolution of the AGM
of January 11, 2022)
26 months
26 months
Not used
Delegation of authority to be
granted to the Board of Direc-
tors with a view to increasing
the capital by issuing ordinary
shares and/or any securities
giving access to the capital in
the context of a merger-ab-
sorption, demerger or partial
contribution of assets decided
by the Board of Directors un-
der the delegation referred to
in the 32nd resolution (33rd
resolution of the AGM of Jan-
uary 11, 2022)
10% of the share capital on
the date of the capital in-
crease decision by the
Board of Directors
Not used
Overall limit on the number of
issues made under the 24th
resolution, the 25th resolu-
tion, the 26th resolution and
the 27th resolution, the 30th
resolution, the 31st resolu-
tion, the 32nd and the 33rd
resolution (34th resolution of
the AGM of January 11,
2022)
-
100% of the share capital
on the date of the capital in-
crease decision by the
Board of Directors
-
Based on the share capital on
the date of the annual finan-
cial report, the overall limit on
the amount of issues
amounts to a maximum nomi-
nal value of 50,004.648 cor-
responding to 12,501.162
shares.
Debt securities:
50,000,000
42
Price
Date and terms of use
by the Board
Purpose of the
resolution
Duration Ceilings
determination
methods
of
Directors
Delegation of authority
26 months
10% of the share capital on
-
Not used
granted to the Board of Direc-
tors to increase the capital by
incorporating premiums, re-
serves, profits or other (35th
resolution of the AGM of Jan-
uary 11, 2022)
the date of the capital in-
crease decision by the
Board of Directors
Authorization to be given to
the Board of Directors to
grant options to subscribe or
purchase Company shares
(36th resolution of the AGM
of January 11, 2022)
38 months
38 months
4% of the share capital on
the day the delegation is
used (6)
Refer to (7)
Not used
Not used
Authorization to be given to
the Board of Directors to pro-
ceed with the free allocation
of existing shares or shares
to be issued to all or part of
the employees and/or corpo-
rate officers of the Company
or of the companies of the
group, in accordance with the
provisions of articles L. 225-
197-1 et seq. of the French
Commercial Code with auto-
matic cancellation of share-
holders' preferential subscrip-
tion rights (37th resolution of
the AGM of January 11,
4% of the share capital on
the day the delegation is
used (6)
-
2022)
Delegation of authority to be
granted to the Board of Direc-
tors for the purpose of issuing
and allocating share subscrip-
tion warrants for the benefit of
(i) members and non-voting
members of the Board of Di-
rectors of the Company in of-
fice on the date of allocation
of warrants who are not em-
ployees or managers of the
Company or one of its subsid-
iaries (if applicable) or (ii) per-
sons bound by a service or
consultant contract to the
18 months
4% of the share capital on
the day the delegation is
used (6)
Any stock warrants
allocated to per-
sons in the catego-
ries listed opposite
will be allocated
under market con-
ditions, both with
regard to their is-
sue price and their
exercise price
Refer to the (8)
Used on April, 1st 2022 for
0.04% (i.e. 5,000 warrants) of
the share capital on the day
of the use of the delegation.
Company or to the one of its
subsidiaries (if applicable) or
(iii) members of any commit-
tee set up by the Board of Di-
rectors or that the Board of
Directors may set up who do
not have the status of em-
ployees or managers of the
Company or one of its subsid-
iaries (if applicable)
(38th resolution of the AGM
of January 11, 2022)
43
Price
Date and terms of use
by the Board
Purpose of the
resolution
Duration Ceilings
determination
methods
of
Directors
Delegation of authority to be
granted to the Board of Direc-
tors in order to decide on the
issue of subscription warrants
for business creator shares
(the "BSPCE2022") with can-
cellation of the preferential
subscription right in favor of a
category of person (39th res-
olution of the AGM of January
11, 2022)
18 months
4% of the share capital as
(9)
Used on April, 1st 2022 for
1.24% (i.e. 155,000 BSPCEs)
of the share capital on the
day of the use of the delega-
tion.
will be recognized immedi-
ately upon admission to
trading of the Company's
shares on the regulated
market of Euronext Paris
(6)
Overall limit on the amount of
issues made under the 36th
resolution, the 37th resolu-
tion, the 38th resolution and
the 39th resolution (40th res-
olution of the AGM of January
11, 2022)
-
4% of the share capital on
the day of the use of the
delegation
-
On the basis of the share
capital on the date of the an-
nual financial report, the over-
all limit on the amount of is-
sues amounts to a maximum
of a nominal value of
2,000.18 corresponding to
500,046 shares.
Delegation granted to the
Board of Directors to increase
the share capital by issuing
Company shares for the ben-
efit of employees participating
in the group savings plan
(41st resolution of the AGM of
January 11, 2022)
18 months
3 % of share capital
Determined by the
Board of Directors,
it being however
specified that if,
when the delega-
tion is used, the
Company's shares
were admitted to
trading on Euronext
Paris, the price
Not used
would be set in ac-
cordance with the
provisions of Article
L. 3332-19 of the
Labor Code
(1) The issue price of shares and securities that may be issued under this delegation is set by the Board of Direc-
tors, and according to the following terms :
in respect of the initial public offering, the subscription price for a new share will result from the offer of
shares and the subscription requests issued by investors within the framework of the so-called "con-
struction of the order book”, as developed by professional practice;
after the initial public offering, the price will be set in accordance with the provisions of articles L. 225-
136-1°, L.22-10-52 and R.22-10-32 of the French commercial code (i.e. on the day of this meeting at
least equal to the weighted average of the prices of the last three trading sessions preceding the start of
the public offering within the meaning of Regulation (EU) no. ° 2017/1129 of June 14, 2017, possibly re-
duced by a maximum discount of 10%).
(2) These amounts are not cumulative. The maximum cumulative ceiling authorized by the General Meeting for
capital increases is set at 100% of the share capital on the date of the capital increase decision by the Board of
Directors.
(3) The issue price of the shares and securities, likely to be issued by virtue of this delegation, will be set by the
Board of Directors, in accordance with the provisions of Article L. 225-136-1° of the Code of commerce and will
therefore be at least equal to the weighted average of the quoted prices of the last three trading days preceding
the launch of the offer, such as, where applicable, reduced by the maximum discount authorized by law (i.e., cur-
rently, 10 %) and corrected in the event of a difference in the date of entitlement, it being specified that (i) in the
event of the issue of transferable securities giving access to the capital, the issue price of the shares likely to re-
sult from their exercise , their conversion or their exchange may, where applicable, be set, at the discretion of the
Board of Directors, by reference to a calculation formula defined by the latter and applicable after the issue of the
said securities (during the exercise, conversion or exchange) in which case the aforementioned maximum dis-
count may be assessed, if the Board of Directors deems it appropriate, on the date of application of the said for-
mula (and not on the date of fixing the price of the issue), and that (ii) the issue price of the securities giving
44
access to the capital issued pursuant to this resolution will be such that the amount received immediately by the
Company, increased, where applicable, by that likely to be received subsequently by it during the exercise, con-
version or exchange of said securities, or, for each share issued as a result of the exercise, conversion or ex-
change of these securities, at least equal to the price issue defined above.
(4) The issue price of the shares issued by virtue of this delegation will be determined by the Board of Directors
and will be at least equal, at the discretion of the Board of Directors, (i) either to the closing share price of the
Company on the regulated Euronext Paris market during the last trading session preceding its fixing, possibly re-
duced by a maximum discount of 20%, (ii) either at the volume-weighted average (in the central order book and
excluding off-market blocks) of the prices of the Company's shares on the regulated Euronext Paris market during
the last 3 trading sessions preceding the setting of the issue price, possibly reduced by a maximum discount of
20%, (iii) either the weighted average share price of the Company on the day preceding the setting of the offer
price, possibly reduced by a maximum discount of 20%, (iv) i.e. the average of 5 consecutive quoted share prices
chosen from the last 30 trading sessions preceding the fixing of the offer price, possibly reduced by a maximum
discount of 20%, taking into account, where applicable, the possible date of entitlement and it being specified that
the issue price of the securities giving access to the capital , possibly issued by virtue of this delegation, must be
such that the amount received immediately by the Company, increased by the amount likely to be received by the
latter upon the exercise or conversion of these securities, is, for each share issued following the issue of these
securities, at least equal to the aforementioned minimum amount, it being finally specified that the day of fixing
the price may be understood, at the discretion of the Board of Directors, in particular from the date of the decision
of the issue of ordinary shares by direct issue or by issue following the exercise or conversion of securities.
It is also specified that for the implementation of said delegation, the preferential subscription right of sharehold-
ers to ordinary shares and other securities giving access to the capital to be issued pursuant to Article L. 228-91
of the French Commercial Code will be deleted in favor of one or more person(s) belonging to one or more of the
following categories of persons:
natural or legal person(s), including companies, trusts, investment funds or other investment vehicles
regardless of their form, under French or foreign law, investing on a regular basis in the pharmaceutical,
biotechnology, or medical technology sector, where applicable on the occasion of the conclusion of an
industrial, commercial, licensing, research or partnership agreement with the Company, and or;
company(ies), institution(s) or entity(ies) whatever their form, French or foreign, exercising a significant
part of their activity in these sectors or in the cosmetics or chemical field or medical devices or research
in these fields or having entered into an industrial, commercial, licensing, research or partnership agree-
ment with the Company, and or;
any credit institution, any French or foreign investment service provider or member of an investment
banking syndicate or any company or investment fund undertaking to subscribe to any issue likely to re-
sult in a capital increase term that could be carried out by virtue of this delegation within the framework
of the setting up of a line of financing in equity or bond, and or;
provider(s) of French or foreign investment services, or any foreign institution(s) having an equivalent
status, likely to guarantee the completion of an issue intended to be placed with persons referred to in (i)
and/or (ii) above and, in this context, to subscribe to the securities issued.
(5) Within the limit of 10% of the capital of the Company (as existing on the date of the transaction) per period of
12 months, to derogate from the conditions for fixing the price provided for by the aforementioned resolutions and
to fix the price of issue of ordinary shares and/or securities giving immediate or future access to issued capital,
according to the following terms. The issue price of ordinary shares that may be issued under said post-IPO dele-
gations of authority will be set by the Board of Directors and must be at least equal to:
either the weighted average price of the Company's share on the day preceding the setting of the offer
price, possibly reduced by a maximum discount of 20%,
or the volume-weighted average (in the central order book and excluding off-market blocks) of the Com-
pany's share price on the regulated Euronext Paris market during the last 3 trading sessions preceding
the issue price, possibly reduced by a maximum discount of 20%,
either the average of 5 consecutive quoted prices (either closing price or weighted average price, for the
5 consecutive prices) of the Company's share chosen from the last 30 trading sessions preceding the
fixing of the price of the offer, possibly reduced by a maximum discount of 20%.
(6) These amounts are not cumulative. The maximum cumulative ceiling authorized by the General Meeting for
issues of securities giving access to capital is set at 4% of the Company's share capital on the day of use by the
Board of Directors of the delegation concerned.
(7) The purchase or subscription price per share will be set by the Board of Directors, with the option of sub-dele-
gating under the conditions provided for by law, at a price at least equal to the closing price of an ordinary share
of the Company admitted to trading on the regulated market Euronext Paris, possibly reduced by a maximum dis-
count of 20%, the day preceding that on which the options are granted, it being specified that its exercise price, in
accordance with the provisions of Article L 225-177 of the Commercial Code, may not be less than 80% of the
average quoted price for the twenty trading sessions preceding the day on which the options are granted.
(8) The issue price of a BSA will be determined by the Board of Directors on the day of issue of said BSA accord-
ing to the characteristics of the latter will be at least equal to the weighted average (in the central order book and
excluding off-market blocks) by the volumes of the closing price of a common share of the Company admitted to
trading on the Euronext Paris regulated market recorded for a period of at least five consecutive trading days to a
maximum of thirty consecutive trading days among the thirty trading days preceding the setting of the subscription
price, possibly reduced by a maximum discount of 15%.
45
(9) Each BSPCE2022 will allow the subscription, under the conditions of article 163 bis G III of the general tax code
as well as the conditions defined below, of one ordinary share with a par value of four thousandths (0.004) of a
euro at an exercise price, determined by the Board of Directors on the date of allocation of the BSPCE2022, it be-
ing specified that this price must be at least equal:
to the IPO price of the Company's shares to trading on the regulated Euronext market in Paris as the
latter will be set by the Board of Directors at the end of the placement period and be the result of the
number of shares offered for subscription and subscription requests from investors within the framework
of the global placement, according to the technique known as "construction of the order book" and this,
for any allocation occurring within 6 months of the completion of the capital increase of the Company
which will be carried out within the framework of the admission of its shares to trading on the regulated
market of Euronext in Paris and subject to the provisions set out in the point below in the event of a capi-
tal increase in the 6 months preceding the implementation of this delegation by the Board of Directors
in the event of one or more capital increases in the 6 months preceding the implementation of this dele-
gation by the Board of Directors, at the subscription price of the ordinary shares adopted during the most
recent of the said capital increases assessed on the date of allocation of each BSPCE2022, less, where
applicable, a discount corresponding to the loss in economic value of the ordinary share since this issue;
for any allocation that would occur outside of the assumptions referred to in the two points above, at the weighted
average of the prices of the last 20 trading sessions preceding the date of allocation of said BSPCE2022 by the
Board of Directors.
4.3. Choice made of one of the two methods of exercising
general management provided for in Article L. 225-51-
1 of the Commercial Code
In accordance with Article L. 225-51-1 of the Commercial Code, the general management of the
Company is assumed, under his responsibility, either by the chairman of the board of directors, or
by another natural person appointed by the board of directors and bearing the title of general
manager.
Pursuant to Article 9 of the Company's Articles of Association, the Board of Directors decided
during the Board meeting of January 11, 2022 that the general management of the Company will
be assumed by a natural person appointed by the Board of Directors and bearing the title of Chief
Executive Officer.
The Chief Executive Officer is vested with the broadest powers to act in all circumstances on be-
half of the Company. He exercises these powers within the limits of the corporate purpose and
subject to those that the law and the Articles of Association expressly attribute to the meetings of
Shareholders and to the Board of Directors. He represents the Company in its relations with third
parties.
Pursuant to Article 15 of the Company's Articles of Association, the Board of Directors, after hav-
ing deliberated, decided to appoint as Chief Executive Officer Mr. Pier Vincenzo Piazza.
4.4. Composition, conditions of preparation and
organization of the work of the Board of Directors
4.4.1. Board of Directors
The Board of Directors of the Company is chaired by Mr. Anders Gersel Pedersen. The General
Management of the Company is undertaken by Mr. Pier Vincenzo Piazza as Chief Executive Of-
ficer, who in this capacity represents the Company with regard to third parties.
The Company is administered by a Board of Directors made up of between three and eighteen
directors.
46
The directors are appointed by the shareholders at a General Meeting, voting pursuant to the
quorum and majority requirements for ordinary general meetings.
Directors may be natural persons or legal entities. Legal entity directors must, at the time they are
appointed, name a permanent representative who shall be subject to the same requirements and
obligations and shall be subject to the same liability as if he/she were a director in his/her own
name, without prejudice to the joint and several liability of the legal entity he/she represents.
Terms of office of directors appointed during the Company’s lifetime last three (3) years. Terms of
office expire at the close of the meeting called to vote on the financial statements of the past fi-
nancial year and held in the year in which the term expires.
Directors may be removed from office, at any time and without cause, by the shareholders at a
General Meeting, voting in accordance with the quorum and majority requirements for ordinary
general meetings.
The proportion of directors aged over eighty (80) may not exceed one-third of the members of the
Board.
In the event that one or more directorships becomes vacant as a result of death or resignation,
the Board of Directors may, between two general meetings, make temporary appointments in or-
der to increase the number of directors.
Any such temporary appointments made by the Board shall be subject to ratification by the share-
holders at the next Ordinary General Meeting. If they are not ratified, the resolutions adopted, and
acts performed shall nevertheless remain valid.
Where the number of directors falls below the statutory minimum, the remaining directors must
immediately convene an Ordinary Meeting in order to increase the number of members of the
Board.
A director appointed to replace another director shall only remain in office for the remainder of the
term of office of his/her predecessor.
Directors who are natural persons may not simultaneously act as directors on more than five
boards of directors or supervisory boards of sociétés anonymes (limited companies) headquar-
tered in mainland France, subject to the exceptions provided for by law.
Employees of the Company may only be appointed directors if their employment contract relates
to an actual role at the Company. They shall not lose the benefit of such employment contracts.
The number of directors who have an employment contract with the Company may not exceed
one-third of the directors in office.
The general meeting can appoint an observer to the Company, natural or legal person, share-
holder or not. The Board of Directors may also appoint one directly, subject to ratification at the
next meeting. On the date of this Governance Report, the Board of Directors has a non-voting
member, Inserm Transfert Initiative, represented by Mr. François Thomas.
The observer will only have consultative power individually or collectively and will not have the
right to vote on the Board of Directors.
In accordance with the Company's internal regulations approved by the Company's board of di-
rectors on January 11, 2022, the observer is subject to Regulation (EU) No. 596/2014 of the
47
European Parliament and of the Council of April 16, 2014 on market abuse (regulation on market
abuse).
The members of the Board of Directors may be remunerated by remuneration for the activity, the
total amount of which is distributed among the members of the Board of Directors, taking into ac-
count in particular their attendance at meetings of the Board of Directors and their participation in
specialized committees.
The number of meetings of the Board of Directors takes into account the various events that
punctuate the life of the Company. Thus, the Board of Directors meets as often as the interests of
the Company require.
During the financial year ended December 31, 2021, the Board of Directors met ten times and the
average attendance rate for directors was 97.3%.
4.4.1.1. Assessment of the work of the Board of Directors
This will take place at the end of the first fiscal year of the Board of Directors of the public limited
company appointed on January 11, 2022, or at any time deemed appropriate by the Chairman of
the Board of Directors.
4.4.1.2. Skills
The Board of Directors shall establish the Company’s business policies and ensure that they are
implemented. Subject to the powers expressly reserved for the general meetings of shareholders
and within the limits imposed by the Company’s corporate purposes, the Board shall review all
issues concerning the Company's operations and shall deal with all matters concerning the Com-
pany.
The Board of Directors shall carry out the checks and verifications it deems appropriate. All direc-
tors shall be sent the information they require to carry out their duties and may ask to be sent any
documents they consider to be relevant.
4.4.2. Committees of the Board of Directors
On the date this report on Governance was drawn up, the Company had set up two Committees:
Audit committee;
Appointments, Compensation and Corporate Social Responsibility (“CSR”) Committee.
The main provisions of the internal regulations of these Committees are presented below.
4.4.2.1. Audit Committee
Composition
The Audit Committee must have at least two members, who should, to the extent possible, be in-
dependent, appointed by the Board of Directors, based on a recommendation of the Appoint-
ments, Compensation and CSR Committee members, being specified that the Chief Executive
Officer cannot be a member of the audit committee. They are appointed for an indefinite period,
which may not exceed their term of office as a member of the Board of Directors and may be re-
moved from office by the Board of Directors. Their term of office is renewable an unlimited
48
number of times. At least one member of the Board must be an independent member with spe-
cific expertise in finance or accounting, it being specified that all members must have a minimum
level of financial and accounting expertise.
At the date of this Report, the members of the Audit Committee are:
Karen Linehan, Chairwoman of the Audit Committee, Director
Brahim Guetarni, Director
Anders Gersel Pedersen, Chairman of the Board of Directors, and;
Inserm Transfert Initiative, represented by François Thomas, observer
Duties
The Audit Committee is responsible for overseeing questions relating to the preparation and audit
of accounting and financial information and, to that end, has responsibility for:
overseeing the closing of the financial statements and, as necessary, issuing any recom-
mendations to ensure their integrity;
overseeing the effectiveness of the internal control and risk management systems, and
any internal audits of procedures relating to the preparation and processing of accounting
and financial information, without undermining its independence;
overseeing the statutory auditors' review of any annual financial statements and consoli-
dated financial statements;
issuing a recommendation on the appointment of statutory auditors by the shareholders
at a General Meeting and issuing a recommendation to the Board of Directors when the
term of office of the statutory auditor(s) comes up for renewal;
ensuring that the statutory auditors carry out their duties and take into consideration the
findings and conclusions of the Haut conseil du commissariat aux comptes (French audit
control board) consecutive to audits they have undertaken;
ensuring that the statutory auditors comply with the independence conditions and take
any appropriate steps where necessary;
approving the supply of non-audit services by the statutory auditors (Article L. 822-11-2 of
the French Commercial Code);
reporting on a regular basis to the Board of Directors regarding the progress of its work
and on the results of the statutory audit, on the way in which that work contributed to the
integrity of the financial information and the role it played in that process. The Audit Com-
mittee immediately reports any problems encountered to the Board of Directors;
reviewing the Company's procedures for receiving, storing and processing complaints in
respect of internal accounting and accounting controls, audit-related issues as well as
documents sent by employees anonymously and confidentially that may call into question
accounting or auditing practices; and
more generally, offering all appropriate advice and recommendations in the above-men-
tioned areas.
49
4.4.2.2. Appointments, Compensation and CSR Committee
Composition
The Appointments, Compensation and Corporate Social Responsibility (CSR) Committee is com-
prised of at least two members appointed by the Board of Directors. They are appointed for an
indefinite period, which may not exceed their term of office as a member of the Board of Directors
and may be removed from office by the Board of Directors. Their term of office is renewable an
unlimited number of times.
For the avoidance of doubt, it should be noted that no member of the Board of Directors exercis-
ing management duties within the Company may be a member of the Appointments, Compensa-
tion and CSR Committee.
At the date of this Report, the members of the Appointments, Compensation and CSR committee
are:
Anders Gersel Pedersen, Chairman of the Committee, Chairman of the Board of Direc-
tors
Karina Hansen, Director
Karen Linehan, Director
Duties
The Appointments, Compensation and CSR Committee is responsible for:
In relation to appointments
making recommendations to the Board of Directors in respect of the positions of Chief Ex-
ecutive Officer and any Deputy Chief Executive Officers, the composition of the Board of
Directors and its Committees;
issuing an annual list to the Board of Directors of directors who may qualify as “independ-
ent members” under the criteria set out in the MiddleNext Code;
preparing a list of persons recommended to be appointed as Chief Executive Officer,
Deputy Chief Executive Officer or Director; and
preparing a list of the directors recommended to be appointed to Board Committees.
In relation to compensation
reviewing the key objectives proposed by the Chief Executive Officer and any Deputy
Chief Executive Officers in relation to the compensation of the Company's managers who
are not executive directors, including bonus share plans, BSPCE plans and options to
subscribe for or purchase shares and incentive arrangements;
reviewing the compensation of managers who are not executive directors, including bo-
nus share plans and options to subscribe for or purchase shares, pension and personal
protection plans and benefits in kind;
submitting recommendations and proposals to the Board of Directors regarding:
the compensation, pension and protection plans, benefits in kind and other
financial rights, including in the event the Company ceases trading, of the Chief Executive
Officer and any Deputy Chief Executive Officers. The Compensation Committee pro-
poses compensation amounts and structures and, in particular, criteria for calculating the
variable portion of compensation, taking account of the Company’s strategy, objectives
and results, as well as market practices, and
50
bonus share plans, options to subscribe for or purchase shares and any other similar in-
centive mechanisms and, in particular, specific awards to the Chief Executive Officer and
any Deputy Chief Executive Officers;
reviewing total compensation based on the activity of the Board of Directors and the sys-
tem for allocating it among the members of the Board of Directors, as well as the condi-
tions for the reimbursement of any expenses incurred by members of the Board of Direc-
tors;
participating in drawing up and overseeing gender equality policies and ensuring that
gender equality principles are effectively implemented at all hierarchical levels of the
Company;
preparing and submitting any reports required under the rules of procedure of the Com-
pensation Committee; and
submitting any other recommendations that may be requested of it by the Board of Direc-
tors or the Chief Executive Officer in relation to compensation.
In relation to CSR
ensuring that corporate social responsibility matters are taken into account in the Com-
pany’s strategy and in its implementation;
reviewing the Company's commitments in relation to sustainable development, in view of
the issues associated with its business activities and objectives; and
reporting to the Board of Directors on the Company's long-term development, including
economic development, as a result of its CSR activities.
More generally, the Appointments and CSR Committee shall provide all appropriate advice and
recommendations in the above-mentioned areas.
4.5. Description of the diversity policy applied to members
of the Board of Directors
Balanced representation of men and women
From the settlement-delivery of the Company’s shares as part of their admission to trading on the
Euronext Paris regulated market, the Board of Directors will have 3 female directors i.e. 50% of
the members of the Board of Directors. The composition of the Board of Directors will therefore
comply with the provisions of Articles L. 225-18-1 and L. 22-10-3 of the French Commercial
Code, which requires a balanced representation of men and women on the Boards of Directors of
companies whose shares are admitted to trading on a regulated market.
4.6. Potential limitations the Board of Directors places on
the power of the Chief Executive Officer
The Chief Executive Officer is vested with the broadest powers to act in all circumstances on be-
half of the Company, within the limits of the corporate purpose, and subject to those expressly
granted by law and the articles of association to shareholders' meetings. and the Board of Direc-
tors. The Managing Director manages the Company.
51
4.7. Specific procedures for the participation of
shareholders in the general meeting or the provisions
of the articles of association which provide for these
procedures
In accordance with articles 20 and 21 of the Company’s Articles of Association:
All shareholders have the right to attend meetings and participate in the deliberations:
personally, or
by giving power of attorney to any natural or legal person of their choice, or
by sending a power of attorney to the Company without indicating the mandate, or
by voting by mail, or
by videoconference or by another means of telecommunication in accordance with the
applicable legal and regulatory provisions.
Participation in general meetings, in any form whatsoever, is subject to registration or registration
of shares under the conditions and within the time limits provided for by the regulations in force.
The final date for returning postal ballots is set by the Board of Directors and communicated in
the notice of meeting published in the Bulletin d'Annonces Légales et Obligatoires (BALO). This
date cannot be earlier than three days before the Meeting.
Shareholders who voted by post will no longer be able to participate directly in the meeting or to
be represented.
In the event of the return of the proxy form and the postal voting form, the proxy form is taken into
consideration, subject to the votes cast in the postal voting form.
Any shareholder may be represented at Meetings by any natural or legal person of their choice,
by means of a proxy form sent to them by the Company:
or at his request, sent to the Company by any means. This request must be received at
the registered office at least five days before the date of the Meeting,
or at the initiative of the Company.
The proxy given by a shareholder to be represented at a Meeting is signed by him, if necessary,
by a secure electronic signature process or by any other reliable identification process guarantee-
ing its link with the act to which it is attached.
The proxy is revocable in the same way as required for its designation.
All the documents and information provided for by the regulations in force must be attached to
any proxy form sent to shareholders by the Company for each Meeting.
The proxy given by a shareholder is only valid for a single Meeting or for successive Meetings
convened with the same agenda. It can also be given for two Meetings, one Ordinary, the other
Extraordinary, held on the same day or in a period of fifteen days.
Any shareholder may vote by mail using a voting form sent to him/her by the Company.
at his/her request, sent in writing. This request must be submitted or received at the regis-
tered office at least six days before the date of the Meeting, or
52
at the initiative of the Company, or
as an appendix to a proxy voting form under the conditions provided for by the regulations
in force.
All postal voting forms sent to shareholders by the Company must be accompanied for each
Meeting by all the documents and information provided for by the regulations in force.
The postal voting form sent by a shareholder is only valid for a single Meeting or for successive
Meetings convened with the same agenda.
4.8. Procedure organized by the Board of Directors to
regularly assess whether agreements relating to
current transactions and entered into under normal
conditions meet these conditions
This procedure falls within the scope of the provisions of Article L.22-10-12 of the French Com-
mercial Code, requiring the Board of Directors of companies whose shares are admitted to trad-
ing on a regulated market to set up a procedure for regularly assessing whether agreements re-
lating to current transactions and entered into under normal conditions meet these conditions.
It aims, on the one hand, to provide details as to the criteria used by the Company to identify and
qualify current transactions entered into under normal conditions to which it is a party, and, on the
other hand, to formalize a procedure enabling the regular assessment of whether these agree-
ments continue to meet these conditions.
Since current transactions entered into under normal conditions are excluded from the authoriza-
tion regime for regulated agreements defined in Article L.225-86 of the Commercial Code, it is ad-
visable to ensure on a regular basis that the conditions allowing such qualification are met, in par-
ticular with regard to the case law in force and the doctrine of the Compagnie Nationale des Com-
missaires aux comptes.
The procedure for evaluating current agreements entered into under normal conditions will be
validated by the Board of Directors during the first half of 2022.
53
4.9. Structure of the share capital of the Company
CAPITAL STRUCTURE ON APRIL 5, 2022
Breakdown of capital and
Breakdown of capital and
voting rights on a non-diluted voting rights on a fully diluted
basis
basis
Shareholders
% of capital and
theoretical voting
rights
% of capital and
theoretical voting
rights
Number of
shares
Number of
shares
Pier Vincenzo Piazza, CEO
Anders Gersel Pedersen, Chairman
Total executive directors
Inserm Transfert Initiative
2,083,200
16.66%
2,664,000
1066,000
2,770,000
1,604,447
1,023,718
334,782
18.75%
0.75%
19.50%
11.29%
7.20%
2.36%
8.27%
4.54%
5.75%
13.10%
4.94%
57.45%
2,083,200
1,604,447
1,023,718
334,782
16.66%
12.83%
8.64%
2,68%
9.40%
5.16%
6.54%
14.88%
5.61%
65.29%
Nouvelle Aquitaine Co-Investissement (1)
(4)
Aqui-Invest (1) (4)
Région Nouvelle Aquitaine (4)
Aquitaine Création Investissement (1)
Aelis Innovation (2)
1,174,872
645,206
1,174,872
645,206
817,006
817,006
FPS Bpifrance Innovation I (3)
Indivior UK Ltd.
1,860,766
701,469
1,860,766
701,469
Total Investors
8,162,266
8,162,266
Founders-managers/managers who
are not executive directors
Total employees, consultants and indi-
vidual non-executive directors
Other shareholders who are individual
non-executive founders
620,366
453,600
4.96%
3.63%
1,193,902
900,708
8.40%
6.34%
478,766
702,964
3.83%
5.62%
478,766
702,964
3.37%
4.95%
Free float
Total
12,501,162
100.00 %
14,208,606
100.00%
(1) Aquiti Gestion has a management mandate for the Aquitaine Création Investissement fund (private investment structure in
which the Nouvelle Aquitaine Region is a 30% shareholder, and an advisory mandate for the Aqui-Invest funds, and Nouvelle
Aquitaine Co-Investment.
(2) The Aelis Innovation fund is represented by the management company Irdi Capital Investissement.
(3) The FPS Bpifrance Innovation I fund is represented by the management company Bpifrance Investissement.
(4) The total represented by the Aquitaine Region and the Aquitaine regional funds represents 20.72% of the capital and voting
rights on a non-diluted basis, and 17.83% of the capital and voting rights on a fully diluted basis.
4.10. Statutory restrictions on the exercise of voting rights
and the transfer of shares or the clauses of the
agreements brought to the attention of the Company
pursuant to article L. 233-11 of the commercial code
Each share gives the right, as regards the profits and corporate assets, to a share proportional to
the share of the capital that it represents.
In addition, it gives the right to vote and to representation at General Meetings under legal and
statutory conditions.
Shareholders are only liable up to the nominal amount of the shares they own, beyond which any
call for funds is prohibited.
54
Ownership of a share automatically implies adherence to the Company's Articles of Association
and to the decisions of the General Meeting.
The heirs, creditors, assignees, or other representatives of a shareholder may not request the af-
fixing of seals to the Company's assets and securities, nor request their division or auction, nor
interfere in the acts of its administration, they must, for the exercise of their rights, refer to the
Company records and the decisions of the General Meeting.
Each time it is necessary to own several shares to exercise any right, in the event of an ex-
change, consolidation or allocation of securities, or as a result of a capital increase or reduction,
merger or other corporate operation, the owners of securities that are isolated or in fewer than the
required number can only exercise these rights on the condition that they make it their personal
business to group together and, possibly, buy or sell the necessary securities.
However, the Company may, in the event of exchanges of securities following a merger or de-
merger, capital reduction, consolidation or division and mandatory conversion of bearer securities
into registered securities, or distributions of securities allocated to reserves or linked to a capital
reduction, or distributions or allocations of free shares, by simple decision of the Board of Direc-
tors, sell securities whose beneficiaries have not requested delivery, on the condition of having
carried out, at least two years in advance, the publication formalities provided for by the regula-
tions.
From the date of this sale, the old shares or the old rights to distributions or allocations are, as
necessary, canceled and their holders can only claim the distribution in cash of the net proceeds
from the sale of the shares unclaimed.
4.11. Direct or indirect holdings in the capital of the
Company which it is aware of according to Articles L.
223-7 and L. 233-12 of the Commercial Code
The shareholding of the Company is detailed in Section 4.9. The Company is not aware of any
indirect holdings modifying these holding rates.
4.12. List of holders of any securities with special control
rights and description thereof
As of the date of this report, there are no special rights granted to holders of the capital. The
shareholders' agreement existing on December 31, 2021, and conferring special rights, was ren-
dered null and void upon settlement-delivery on February 17, 2022.
4.13. Control mechanisms provided for in a possible staff
shareholding system, when the control rights are not
exercised by the latter
As the Company has not set up any share allocations under a Company Savings Plan, no direc-
tor representing employee shareholders has been appointed.
55
4.14. Agreements between shareholders which the
Company is aware of and which may entail
restrictions on the transfer of shares and the exercise
of voting rights
The Company is not aware of any agreement between shareholders.
4.15. Rules applicable to the appointment and replacement
of members of the Board of Directors as well to the
modification of the articles of association
The applicable rules regarding the appointment and replacement of members of the Board of Di-
rectors are described in Section 4.4.1 Board of Directors.
The Extraordinary General Meeting alone is authorized to modify the Articles of Association in all
their provisions and in particular to decide on the transformation of the Company into a company
of another form. It may not, however, increase shareholders' commitments, subject to operations
resulting from a duly carried out consolidation of shares.
The Extraordinary General Meeting can only deliberate validly if the shareholders present, repre-
sented or voting by mail hold at least, on first call, one quarter of the shares with voting rights
and, on second call, one fifth of the shares with voting rights. In the absence of this last quorum,
the second Meeting may be postponed by a maximum of two months from the date on which it
was convened.
It rules by a majority of two-thirds of the votes cast by the shareholders present, represented or
voting by post or participating in the Meeting by videoconference or by another means of tele-
communication in accordance with legal and regulatory provisions.
By legal derogation from the preceding provisions, the General Meeting which decides on a capi-
tal increase by way of incorporation of reserves, profits or issue premiums, may rule under the
quorum and majority conditions of an Ordinary General Meeting.
4.16. Powers of the Board of Directors, in particular with
regard to the issue or redemption of shares
For a description of the delegations and authorizations to issue shares granted to the Board of
Directors, see Section 4.2.8 of the Report on Corporate Governance.
As part of the Company's plan to list the Company on Euronext Paris, the general meeting of
shareholders of the Company on January 11, 2022 authorized, under the terms of its 22nd reso-
lution, the Board of Directors, for a period of eighteen months from the date of the meeting, to im-
plement a Company share buyback program under the conditions provided for in Articles L. 22-
10-62 et seq. of the French Commercial Code and in accordance with the provisions of the gen-
eral regulations of the AMF.
The general meeting thus:
decided that the acquisition, sale or transfer of these shares may be carried out by any
means, on one or more occasions, in particular via the market or over the counter,
56
including by acquisition or sale of blocks, public offers, by using optional or derivative
mechanisms, under the conditions provided for by the market authorities and in compli-
ance with the applicable regulations;
decided that the authorization may be used to:
ensure the liquidity of the Company's shares under a liquidity contract to be entered into
with an investment services provider, acting independently, in accordance with market
practice accepted by the AMF;
honor obligations related to stock option plans, free share allocations, employee savings
plans or other allocations of shares to employees and managers of the Company or com-
panies that related to it as well as to carry out all hedging transactions relating to these
transactions under the conditions and in accordance with the provisions provided for by
the applicable laws and regulations;
deliver shares on the occasion of the exercise of rights attached to securities giving ac-
cess to the capital as well as to carry out all hedging transactions relating to these trans-
actions under the conditions and in accordance with the provisions provided for by the
laws and applicable regulations;
purchase shares for retention and subsequent delivery for exchange or payment in the
context of any external growth, merger, demerger or contribution operations;
cancel all or part of the shares thus repurchased under the terms indicated in the 23rd
resolution approved by the general meeting of January 11, 2022, or;
more generally, to operate for any purpose that may be authorized by law or any market
practice that may be accepted by the market authorities, it being specified that, in such a
case, the Company would inform its Shareholders by a press release;
decided to set the maximum unit purchase price per share (excluding fees and commis-
sions) at 300% of the price per share retained in the context of the IPO, with an overall
ceiling of 10,000,000, being specified that this purchase price will be subject to any nec-
essary adjustments to take account of capital transactions (particularly in the event of in-
corporation of reserves and free allocation of shares, splits or consolidation of shares)
which would take place during the period of validity of this authorization,
decided that the maximum number of shares that may be purchased pursuant to this res-
olution may not, at any time, exceed 10% of the amount of the share capital at any time
whatsoever, this percentage applying to an adjusted capital depending on the transac-
tions affecting it subsequent to the present, it being specified that when the shares are
acquired for the purpose of promoting the liquidity of the Company's shares, the number
of shares taken into account for the calculation of this limit will correspond to the number
of shares purchased after deduction of the number of shares resold during the duration of
the authorization, and
granted all powers to the Board of Directors with the option of sub-delegation under the
conditions provided for by law, in order to implement this authorization, in particular to
judge the advisability of launching a buyback program and to determine terms, place all
stock market orders, sign all deeds of assignment or transfer, conclude all agreements,
all liquidity contracts, all option contracts, make all declarations to the AMF and any other
body, and all necessary formalities, in particular allocating or reassigning the acquired
shares to the various formalities, and, in general, doing all that is necessary (the “Authori-
zation”).
By using this Authorization, the Board of Directors on February 15, 2022 authorized the imple-
mentation of a share buyback program with a view to:
57
ensure the liquidity of the Company's shares under a liquidity contract to be entered into
with an investment services provider, acting independently, in accordance with market
practice accepted by the AMF;
honor obligations related to stock option plans, free share allocations, employee savings
plans or other allocations of shares to employees and managers of the Company or com-
panies related to it as well as to carry out all hedging operations relating to these opera-
tions under the conditions and in accordance with the provisions provided for by the appli-
cable laws and regulations;
deliver shares on the exercise of rights attached to securities giving access to the capital
as well as to carry out all hedging transactions relating to these transactions under the
conditions and in accordance with the provisions provided for by law and applicable regu-
lations;
purchase shares for retention and subsequent delivery for exchange or payment in the
context of any external growth, merger, demerger or contribution operations;
cancel all or part of the shares thus repurchased under the terms indicated in the 23rd
resolution approved by the general meeting of January 11, 2022, or;
more, generally, to operate for any purpose that may be authorized by law or any market
practice that may be accepted by market authorities, it being specified that, in such a
case, the Company would inform its Shareholders by way of a press release.
In this context, the Company entered into a liquidity contract on February 15, 2022 with ODDO
BHF SCA, in accordance with the legal framework in force. This contract became active at the
end of the over-allotment period.
The Liquidity Contract was concluded for a period of 12 months and is renewable by tacit agree-
ment for periods of one (1) year, except in the cases of termination provided for in the contract, it
being specified that, by way of derogation, the first year will begin from the date of its signature
and will end on December 31.
The purpose of the Liquidity Contract is for the intervention of ODDO BHF SCA on Euronext
Paris, on behalf of the Company, with a view to promoting the liquidity of the Company’s shares
and to ensure share price stability in order to avoid price shifts not justified by the market trend.
For the implementation of this contract, the Company has decided to allocate an amount of
500,000 to the liquidity account.
The execution of the Liquidity Contract will be suspended in the cases provided for by the AMF
and/or Euronext, in the event of suspension of the price of the shares by Euronext, in the event
that the Company no longer has a buy-back authorization. of its own shares or, in accordance
with the provisions of Article 5 of AMF Decision No. 2021-01 of June 22, 2021, during the imple-
mentation of stabilization measures within the meaning of the Market Abuse Regulation as well
as during a public pre-offer period and until the closing of the offer, when the issuer is the initiator
of the offer or when its securities are targeted by the offer.
The Liquidity Contract entered into force from the end of the stabilization period of the Offer, i.e.
from March 18, 2022.
58
4.17. Agreements entered into by the Company modified or
terminated in the event of a change in control of the
Company, unless such disclosure seriously harms its
interests
At the date of this report, there are no significant agreements entered into by the Company which
are modified, or which terminate in the event of a change of control of the Company, with the ex-
ception of certain public financing contracts awarded to the Company.
4.18. Agreements providing for compensation for directors
or employees in the event of resignation or dismissal
without real and serious cause or termination of
employment following a takeover or exchange offer
An indemnity equal to 6 months of gross compensation (based on the annual compensation
which includes the fixed part, the variable part and, if applicable, exceptional compensation)
would be paid to Pier Vincenzo Piazza in the event of termination of his duties as Chief Executive
Officer resulting from a decision of the Board of Directors.
4.19. Restrictions imposed by the Board of Directors with
regards to share subscription or purchase options
granted to executive directors
No restrictions are imposed by the Board of Directors.
4.20. Remuneration policy
4.20.1. Compensation of executive officers
4.20.1.1.Compensation of executive officers in the previous two financial
years
The tables below show the compensation paid to Anders Gersel Pedersen, Chairman of the
Board of Directors since his appointment on February 18, 2020 (the role of Chairman of the
Board of Directors was fulfilled in 2019 and until the appointment of Anders Gersel Pedersen by
François Thomas, representative of Inserm Transfert Initiative and, as such, was unpaid) and to
Pier Vincenzo Piazza, Chief Executive Officer, of the Company in the financial years ending De-
cember 31, 2020 and 2021.
59
TABLE 1 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02 - SUMMARY OF THE
COMPENSATION AND THE OPTIONS AND SHARES AWARDED TO EACH EXECUTIVE OFFICER
Financial year
2020
Financial year
2021
Amounts in euros
Pier Vincenzo Piazza, Chief Executive Officer (1)
Compensation payable in respect of the financial year (de-
tailed in Table 2)
346,643
None
501,137
None
Valuation of the multi-year variable compensation
awarded during the financial year
Value of options awarded during the year
Value of other long-term compensation plans
Total for Pier Vincenzo Piazza
None
None
None
None
346,643
501,137
(1) Since the Company's conversion to a société anonyme (limited company), on January 11th, 2022, the Chief
Executive Officer appointed by the newly formed Board of Directors is Pier Vincenzo Piazza. The compensation
amounts set out in this table therefore relate exclusively to the compensation received by Pier Vincenzo Piazza in
respect of the two most recent financial years, during which periods he was Chairman (within the meaning of Arti-
cle 227-6 of the French Commercial Code) of Aelis Farma while it was incorporated in the form of a société par
actions simplifiée (simplified joint-stock company).
TABLE 1 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02 SUMMARY OF THE
COMPENSATION AND THE OPTIONS AND SHARES AWARDED TO EACH EXECUTIVE OFFICER
Financial year
2020
Financial year
2021
Amounts in euros
Anders Gersel Pedersen, Chairman of the Board of Directors (1)
Compensation payable in respect of the financial year (de-
tailed in Table 2)
66,500
-
70,000
-
Valuation of the multi-year variable compensation
awarded during the financial year
Value of options awarded during the year (2)
Value of other long-term compensation plans
Total for Anders Gersel Pedersen
87,290
-
-
-
153,790
70,000
(1) Compensations mentioned in this table related exclusively to the compensations received by Ander Gersel
Pedersen as statutory Chairman of the Board of Directors of Aelis Farma while it was incorporated as a simplified
joint-stock company.
(2) This value relates to the 4,000 BSPCEs attributed to Anders Gersel Pedersen.
60
TABLE 2 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02 - SUMMARY OF THE
COMPENSATION OF EACH EXECUTIVE OFFICER (PIER VINCENZO PIAZZA)
Amounts in euros
Financial year 2020
Financial year 2021
Pier Vincenzo Piazza, Chief Executive
Officer (1)
Awarded
Paid
209,804
Awarded
Paid
Annual fixed compensation
209,804
88,334
0
238,773
118,750
0
238,773
118,750
0
Annual variable compensation
Multi-annual variable compensation
Extraordinary compensation
158,334 (2)
0
24,084
24,084 (2)
120,000
120,000
Compensation awarded for director-
ships
0
0
0
0
Accommodation allowance
24,421
24,421
23,614
23,614
Total for Pier Vincenzo Piazza
346,643
416,643
501,137
501,137
(1) Since the Company's conversion into a société anonyme (limited company), on January 11th, 2022, the Chief
Executive Officer appointed by the newly formed Board of Directors is Pier Vincenzo Piazza. The compensation
amounts set out in this table correspond exclusively to the compensation received by Pier Vincenzo Piazza in re-
spect of the two most recent financial years, during which periods he was Chairman (within the meaning of Article
227-6 of the French Commercial Code) of Aelis Farma while it was incorporated in the form of a société par ac-
tions simplifiée (simplified joint stock Company).
(2) The amounts of variable compensation paid in 2020 include variable compensation for 2019 (€70,000) and
2020 (€88,334 in annual variable compensation).
The Chief Executive Officer’s annual variable compensation is awarded based on targets set at
the start of the financial year by the Board of Directors on a recommendation from the Compen-
sation Committee, and taking into account any other event that, during the year, caused the tar-
gets decided at the start of the year to be modified or changed. All these criteria are reviewed at
the end of the year by the Board of Directors based on the proposal of the Compensation Com-
mittee. The criteria are based on targets that may change from one year to the next and that may
include, for example, financial targets (raising of dilutive and/or non-dilutive funds) and opera-
tional targets (adherence to the timetable for clinical and preclinical studies and for filing patent
applications, or recruitment targets). An exceptional bonus may be awarded in the event that any
of these criteria are exceeded by a considerable degree, or a major event is successfully han-
dled.
The criteria set by the remuneration committee for the variable portion of Pier Vincenzo Piazza’s
compensation were based on the following objectives:
Fiscal year 2020
The objectives, evaluated in the context of a year turned upside down by the pandemic, were as
follows:
compliance with the development schedule of the various research programs (clinical and
pre-clinical) with specific objectives for each program, and taking into account the uncer-
tainty caused by the pandemic;
obtaining non-dilutive financing in the context of the pandemic.
These objectives were considered to be 100% achieved. An exceptional bonus of 10% was
granted to Pier Vincenzo Piazza in view of the quality of the scientific results achieved (phase 2a
61
study of AEF0117) and the high level of secured non-dilutive funds and the efficient reorganiza-
tion of the Company under the new working conditions imposed by the pandemic.
Fiscal year 2021
The objectives evaluated during fiscal year 2021 were as follows:
compliance with the development schedule and the regulatory schedule of the various re-
search programs (clinical and pre-clinical) with specific objectives for each program;
obtaining non-dilutive or non-dilutive financing over the financial year (quantified objec-
tive);
implementation of the recruitment plan defined over the financial year.
These targets were considered to be 95% achieved. An exceptional bonus of 120,000 was
granted to Pier Vincenzo Piazza following the signing of the license option agreement with In-
divior PLC in June 2021.
Pier Vincenzo Piazza, like the Company’s other employees, may benefit from invention bonuses
upon the filing of patents under the Company’s intellectual property development policy. He re-
ceived an exceptional bonus of €2,000 under this policy on December 31, 2020.
Fiscal year 2022
In accordance with the authorization given at the Board of Directors meeting of December 21,
2021, the Board of Directors meeting of April 1, 2022 decided to award, on the proposal of the
Compensation Committee, an exceptional bonus of 125,000 to the Chief Executive Officer in
connection with the listing of the Company on the regulated Euronext market on February 18,
2022.
The Board of Directors of April 1, 2022 set, on the proposal of the Compensation Committee, the
objectives which will be assessed during the 2022 financial year, and which will determine the al-
location of the variable part of the compensation of the Chief Executive Officer:
Comply with the research and development schedule and the regulatory schedule for the
various research programs (AEF0117, AEF0217 and New CB1-SSi) according to the ob-
jectives announced to the market;
Submit new scientific publications and patents;
Establish and implement a roadmap for new recruitments, investor relations and commu-
nication.
62
TABLE 2 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02- SUMMARY OF THE
COMPENSATION OF EACH EXECUTIVE OFFICER (ANDERS GERSEL PEDERSEN)
Amounts paid in euros
Financial year 2020
Financial year 2021
Anders Gersel Pedersen, Chairman of the Board
of Directors (1)
Awarded
Paid
35,000
Awarded
Paid
Annual fixed compensation (2)
Annual variable compensation
Multi-annual variable compensation
Extraordinary compensation
35,000
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Compensation awarded for directorships (2)
Benefits in kind
31,500
-
0
-
70,000
-
70,000
-
Total for Anders Gersel Pedersen
66,500
35,000
70,000
70,000
(1) The compensation amounts set out in this table correspond exclusively to the compensation received by An-
ders Gersel Pedersen in respect of the two most recent financial years, during which periods he was Chairman of
the Board of Directors of Aelis Farma while it was incorporated in the form of a société par actions simplifiée (sim-
plified joint stock Company).
(2) The annual compensation of 2020 comprises (i) the compensation received by Anders Gersel Pedersen for
carrying out his role as a Director (€31,500) and (ii) the compensation he received under the consultancy agree-
ment entered into on February 18, 2020 by Gerselconsult ApS, whose Chief Executive Officer is Anders Gersel
Pedersen, and the Company (€35,000). This agreement, as amended, was terminated in 2021.
4.20.1.2.Compensation of the executive officers in respect of the current
financial year
TABLE 11 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02) COMPENSATION OF
THE EXECUTIVE OFFICERS IN RESPECT OF THE CURRENT FINANCIAL YEAR
Compensation or
benefits due or
Employment Supplementary that might be due
Compensation
under a
contract
pension plan
because of the
termination or
change of position
non-compete
clause
Executive
officers
Yes
No
Yes
No
Yes
No
Yes
No
Pier Vincenzo
Piazza, Chief
Executive Officer
X
X
X
X
X (*)
X
X
Anders Gersel
Pedersen, Chair-
man of the Board
of Directors
X
(*) By a resolution of the Board of Directors dated December 15, 2020, a compensation equal to six months’
gross compensation (based on annual compensation which includes fixed and variable and, if applicable, excep-
tional compensation) is to be paid to Pier Vincenzo Piazza in the event that he ceases to act as Chairman/Chief
Executive Officer pursuant to a resolution of the Board of Directors.
63
4.20.1.3.Other components of compensation
Award of bonus shares
None.
Stock subscription or purchase options
Please refer to section 4.20.5.
4.20.2. Compensation of members of the Board of Directors
In relation to the 2021 financial year, the shareholders at the General Meeting held on June 25,
2021 approved an overall compensation package for the members of the Board of Directors of
€55,000, of which the Board of Directors has paid a total amount of €43,000 to its members in re-
spect of the 2021 financial year. Additional compensation of 35,000, excluding attendance fees,
was also paid to Mr. Anders Gersel Pedersen for his duties as Chairman of the Board of Direc-
tors.
4.20.2.1.Compensation of members of the Board of Directors
The table below sets out the compensation paid to directors and the other compensation received
by non-executive officers during the financial years ended on December 31, 2020 and 2021.
TABLE 3 OF APPENDIX 2 OF THE AMF POSITION-RECOMMENDATION DOC-2021-02) COMPENSATION
PAID TO DIRECTORS AND OTHER COMPENSATION RECEIVED BY NON-EXECUTIVE OFFICERS
Amounts
awarded in
respect of the
2020 financial
year
Amounts paid Amounts
Amounts paid
during the
2021 financial
year
during the
2020 financial
year
awarded in
respect of the
2021 financial
year
Non-executive
officers
(euros)
(euros)
(euros)
(euros)
Inserm Transfert Initiative,
Represented by François Thomas, observer (1)(2)
Compensation
(fixed, variable)
Other compensation
15,000
15,000
20,000
20,000
Les Thélémites,
Represented by Alain Sainsot, director (1)(2)
Compensation
8,000
12,200
-
13,000
-
13,000
-
(fixed, variable)
Other compensation
-
(1) These individual representatives and legal entity directors were remunerated through their respective consult-
ing companies.
(2) As of the date of this Report these persons are no longer directors of the Company. Inserm Transfert Initiative,
represented by François Thomas, was a director until January 11, 2022 and was appointed as censor on that
date.
64
4.20.2.2.Other compensation relating to all officers
As the officers have neither received nor exercised any BSAs or BSPCEs (subscription warrants)
during the financial year ending December, 31 2021, this Report does not include tables 4 and 5
appended to the AMF Position - Recommendation DOC-2021-02 entitled "Guide to the prepara-
tion of universal registration documents” for the financial years 2020 and 2021.
During its meeting of April 1, 2022, the Board of Directors decided to allocate BSAs and BSPCEs
(subscription warrants) to corporate officers under the following conditions:
APRIL 1ST2022 ALLOCATION OF BSAS AND BSPCES
Number
and date
of the
Valuation Number
Type
of
warrants
of
of
Exercise
price
Exercise
period
Officers
warrants
(1)
warrants
granted
plan
Anders
Pedersen,
Gersel
04/30/2024
-
03/31/2032
BSPCE2022
04/01/2022
BSPCE
BSPCE
BSPCE
BSPCE
-
-
-
-
10,000
5,000
5,000
5,000
14.02€
14.02€
14.02€
14.02€
Karina Hansen
Irina Staatz
BSPCE2022
04/01/2022
04/30/2024
-
03/31/2032
BSPCE2022
04/01/2022
04/30/2024
-
03/31/2032
Karen Linehan
BSPCE2022
04/01/2022
04/30/2024
-
03/31/2032
(1) the valuation of these warrants will be determined when preparing the half-year financial statements of June
30, 2022, in accordance with IFRS2.
4.20.2.3.Loans and security interests granted to members of the
Company’s administrative, management or supervisory bodies
None.
4.20.3. Compensation of members of the Board of Directors once
the Company’s shares are admitted to trading on the
Euronext Paris regulated market
The shareholders at the meeting held on January 11th, 2022 approved an overall compensation
package for the members of the Board of Directors of €300,000 which the Board of Directors will
be able to pay to its members in respect of the 2022 financial year, and €300,000 in respect of
subsequent financial years, until a new resolution is passed by the shareholders at a General
Meeting.
Only independent directors will receive compensation, which will include a fixed part, as compen-
sation for their functions as independent director and, where applicable, member or chairman of
one of the Committees of the Board of Directors, and a variable part, the amount of which will de-
pend on their effective participation in the meetings of the Board of Directors and, where applica-
ble, in the meetings of the Committees of which they are members.
65
Mr. Anders Gersel Pedersen, Chairman of the Board of Directors, will receive, in his capacity as
independent director only, a fixed annual remuneration of 100,000. Karina Hansen, Karen
Linehan, and Irina Staatz-Granzer will each receive, in their capacity as independent directors,
fixed annual remuneration of 20,000to which will be added a variable remuneration of 1,500
per meeting of the Board of Directors, this variable remuneration increases to 2,500 for chairing
a committee.
It is planned to increase the compensation of the Chief Executive Officer of the Company after
the Company's admission to the regulated market to €300,000 of fixed compensation, associated
with variable compensation equivalent to 50% of the fixed compensation (on the basis of criteria
described above), and any exceptional bonuses that may be offered by the Compensation Com-
mittee.
On April 1st, the Board of Directors also decided to grant the Chief Executive Officer a bonus re-
lating to the listing of the Company's shares on the regulated market of Euronext Paris in the
amount of 125,000 (out of a maximum amount of 150,000 authorized ex-ante by the Board of
Directors on January 11, 2022). The payment of the housing allowance to the Chief Executive Of-
ficer is intended to continue after the Company's IPO (for an annual amount of approximately
25,000). Similarly, the payment to the latter of an indemnity equal to 6 months of gross remuner-
ation (based on the annual remuneration which includes the fixed part, the variable part, and, if
applicable, exceptional remuneration) in the event of termination of his functions resulting from a
decision of the Board of Directors, is intended to continue.
4.20.4. Amounts set aside by the Company to pay allowances,
pensions and other benefits to officers
The Company has not set aside any amounts to pay allowances, pensions and other benefits to
officers.
The Company has not made any golden handshake or golden hello payments to officers.
4.20.5. Shareholdings and stock-options of members of the Board
of Directors
The table below presents, on the date of preparation of this report on Governance, the interests
held by each corporate officer, on a non-diluted and fully diluted basis.
66
SHARES HELD BY EACH MEMBER OF THE BOARD OF DIRECTORS
Undiluted Capital
BSPCE
BSA
Diluted capital
Members of the
Board of
Directors
% of
capital
and voting exercise of
rights BSPCE
Number of
shares upon
Number of
shares upon
exercise of
BSA
% of
capital
and voting
rights
Number of
shares
Number
of shares
Mr. Anders Gersel
Pedersen,
Chairman of the Board
of Directors
0
0
96,000
0
96,000
0.68
M. Pier
Vincenzo Piazza,
Chief Executive Officer
2,083,200
1,174,872
16.69
9.41
218,400
0
362,400
0
2,664,000
1,174,872
18.99
8.38
Région Nouvelle-Aqui-
taine, represented by
M. Brahim Guetarni
Karina Hansen
Director
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Karen Linehan
Director
Irina Staatz-Granzer
Director
Inserm Transfert
Initiative, represented
by M. François
1,604,447
12.86
0
0
1,604,447
11.44
Thomas, Censor
The number of shares indicated above takes into account the division of the nominal by 24 de-
cided at the AGM of January 11, 2022, and the transactions carried out on February 17, 2022
within the framework and following the introduction of the Company on the regulated market of
Euronext Paris.
4.21. Ethics of the members of the Board of Directors
In accordance with recommendation no. 1 of the MiddleNext Code, each director is made aware
of the responsibilities incumbent on him/her at the time of his appointment and is encouraged to
observe the rules of ethics relating to his term of office and in particular:
the search for exemplarity which implies, at all times, consistent behavior between words
and deeds, a guarantee of credibility and trust, when accepting the mandate;
each member of the Board of Directors becomes aware of the resulting obligations and,
in particular, those relating to the legal rules for the accumulation of directorships;
at the beginning of his/her term of office, he/she signs the internal regulations of the
Board of Directors;
during the term of office, each director must inform the Board of Directors of any situa-
tions of potential conflict of interest (client, supplier, competitor, consultant, etc.) or proven
(other terms of office) concerning him/her;
67
in the event of a conflict of interest, and depending on its nature, the director abstains
from voting, or even from participating in the deliberations, and in the extreme, resigns;
each member of the Board of Directors is diligent and takes part in the meetings of the
Board of Directors and of the Committees of which he is a member;
each member of the Board of Directors ensures that he has obtained all the necessary
information and in sufficient time on the subjects that will be discussed during the meet-
ings;
each member of the Board of Directors respects true professional secrecy with regard to
third parties, and;
each member of the Board of Directors attends the meetings of the General Assembly.
4.22. Senior Management
It was decided, on January 11, 2022, to separate the functions of Chairman of the Board of Direc-
tors and Chief Executive Officer.
At the date of this Financial Report, General Management is provided by Mr. Pier Vincenzo Pi-
azza, who performs the duties of Chief Executive Officer with no other limitation of powers than
those provided for by the texts in force concerning the specific powers of the Board of Directors
or the General Meeting of shareholders. The Chief Executive Officer has the option of partially
delegating his powers to one or more agents. The Chief Executive Officer's business address is
the registered office of the Company.
SENIOR MANAGEMENT
Date of initial
appointment and
end of term
Principal roles and
offices outside the
Company
Name
Position
First appointed:
January 11, 2022*
Expiry of term of office:
Unlimited duration
Pier Vincenzo Piazza
Chief Executive Officer
None
*Prior to his appointment as Chief Executive Officer of the Company by the Board of Directors meeting on Janu-
ary 11 (following the transformation of the Company from a joint-stock company (SAS) into a limited company).
Pier Vincenzo Piazza held the position of Chairman of the SAS since December 20, 2017.
68
4.23. Equity ratio
The table below details executive compensation in the form of salaries, benefits in kind, attend-
ance fees and other employee benefits, determined in accordance with IFRS2.
EQUITY RATIOS
Fiscal year
2021
Fiscal year
2020
Fiscal year
2019
Fiscal year
2018
Fiscal year
2017
Chair-
Chair-
man
CEO of
of the
Chair-
man
CEO of
of the
Chair-
man of
the
Board of
Direc-
tors
Chair-
man of
the
Board of Com-
Direc-
tors
man of
CEO
CEO
of the
Com-
pany
CEO of
the
Type of ratio
of the
Com-
pany
the
the
Com-
pany
the
Com-
pany
Board
of
Direc-
tors
Board
of
Direc-
tors
Board
of
Direc-
tors
pany
Executive
compensation /
average employee
compensation
6.49
9.05
0.91
1.26
3.27
5.01
6.41
2.22
2.84
7.28
3.99
0.19
0.28
0.96
5.41
5.07
0.36
0.34
1.24
0.83
0.91
2.99
-
-
-
Executive
compensation /
median employee
compensation
5.69
Executive
compensation /
23.37
16.42
19.71
18.73
annual
wage
minimum
4.24. Corporate Social Responsibility
As part of its IPO on Euronext Paris and in accordance with the recommendations of the Middlen-
ext code, the Company set up, after December 31, 2021, a CSR committee. The latter is partof
the Remuneration Committee, which has not yet met on the date of preparation of this report.
Given its service and research and development activity, the Company will endeavor, from the
2022 financial year, to reflect on its environmental impact and in particular that of its molecules on
the environment, through studies measuring the penetration of its product into the environment
(in particular into the aquatic environment).
69
Section 5 - Financial statements prepared in accordance
with IFRS as of December 31, 2021
STATEMENT OF NET INCOME
In thousands of euros
Note
12/31/21 12/31/20
Revenue
5.2
5.3
9,075
1,687
10,762
(6,870)
(1,340)
2,552
-
-
Other operating income
1,137
1,137
(3,388)
(658)
(2,910)
70
Revenue from ordinary activities
Research and Development costs
General and administrative costs
Recurring operating profit (loss)
Other operating income and expenses
Operating profit (loss)
5.4
5.5
5.8
5.9
2,552
(794)
1,759
(1,185)
574
(2,840)
(202)
(3,042)
956
Financial income (loss)
Profit (loss) before tax
Income tax expense
5.10
Net income (loss)
(2,086)
(5,22)
(5,22)
Basic earnings per share (€/share)
Diluted earnings per share (€/share)
4.6.3
4.6.3
1,44
3,87
STATEMENT OF COMPREHENSIVE INCOME
In thousands of euros
Note
12/31/21 12/31/20
Net income (loss)
574
(2)
(2)
-
(2,086)
Items will not be reclassified subsequently to profit or loss
Actuarial gain (loss) on employee benefit obligation
Tax effect
(2)
(2)
-
4.8
3.4
Items that may be reclassified subsequently to profit or loss
527
-
Fair value gain/(loss) arising on hedging instruments during the period
527
-
(1)
Tax effect
-
-
Comprehensive profit (loss)
(1,098)
(2,088)
(1) Application of hedge accounting to end-of-period cash
70
STATEMENT OF FINANCIAL POSITION
In thousands of euros
Note
12/31/21
12/31/20
Intangible assets
4.1
4.2
90
196
60
48
Property, plant and equipment
Deferred tax assets
5.10
0
956
Total non-current assets
Receivables and prepaid expenses
Inventory
287
1,064
1,396
4.4
4.5
3,299
17
Cash and cash equivalents
Total current assets
24,710
28,027
28,313
899
4,538
5,935
6,999
(709)
110
TOTAL ASSETS
Shareholders’ equity
Employee commitments
Non-current financial debts
Other debts non-current
Passive derivatives
4.6
4.8
101
4.9
5,254
6,339
1,505
13,199
1,158
2,243
469
5,787
-
4.10
4.9
222
Total non-current liabilities
Current financial liabilities
Trade payables and related items
Fiscal and social debts
Deferred revenue
6,119
328
4.9
4.10
4.10
4.10
927
304
10,346
-
-
Other current debts
32
Total current liabilities
TOTAL EQUITY AND LIABILITIES
14,216
28,313
1,590
6,999
71
CASH FLOW STATEMENT
In thousands of euros
Note
12/31/21
12/31/20
Profit (loss) for the period
5
574
36
(2,086)
30
(+) Depreciation and amortization of intangible and tangible assets
(+) Expenses related to share-based payments
(+) Expenses related to defined benefit plans
5.7
5.6
443
24
172
25
4.8.3
(+) Neutralization of the impact of the restatement of government
grants on net income
5.3
(16)
19
(+) Reclassification of interest income and expenses
(+) Income tax expense
5.9
740
103
5.10.1
1,185
(956)
Net cash flow from operating activities before changes in
working capital requirements, financial interest and income
taxes
2,985
(2,693)
Change in working capital requirement (net of impairments of trade
receivables and inventories)
16,383
116
(-) Research tax credit and income taxes for the year
(+) Research tax credit collected
5.3
5.3
(1,089)
692
(692)
791
Net cash flows from operating activities
18,970
(2,478)
4.1
4.2
Acquisitions of intangible and tangible assets
(213)
(35)
Financial interest received on investments
Net cash flows from investing activities
Capital increase net of the conversion of bonds
Costs relating to the capital increase
Issuance of bond loans net of fees
Subscription of BSA
1
(212)
-
1
(34)
-
-
-
-
-
4.6.1
35
2
Issuance of bank loans
-
63
Receipt of advances and loans for innovation, net of costs
Repayment of advances and loans for innovation
Repayment of debt on lease liabilities
Gross financial interest paid
4.9.2
4.9.2
4.9.2
4.9.2
5.9
447
(140)
(25)
(63)
(74)
180
1,350
(70)
(24)
-
Net cash flows from financing activities
Effect of exchange rate changes
(44)
1,277
4.9.4
5.9
Net increase or decrease in cash and cash equivalents
1,235
-
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Profit (loss) for the period
20,172
4,538
(1,235)
5,771
4,538
24,710
72
STATEMENT OF CHANGES IN EQUITY
Other
compre-
capital premium hensive
income
Reserve
and
retained
earnings
Share Share
Total
equity
In thousands of euros
Equity at 12/31/19
4
6,631
(20)
(5,411)
1,203
Profit (loss) for the period
Other comprehensive income
Total comprehensive income
Capital increase net of fees
Share-based payments
Other
-
-
-
(2,086)
(2,086)
-
-
-
-
-
-
-
-
(2,086)
(2,086)
-
-
-
-
-
172
-
-
-
-
172
-
-
-
-
(20)
-
Equity at 12/31/20
4
-
6,631
(7,325)
574
-
(711)
574
525
1,099
35
Profit (loss) for the period
Other comprehensive income
Total comprehensive income
Capital increase net of fees
Share-based payments
Other
-
-
-
525
525
-
-
-
574
-
-
35
-
-
-
-
443
34
443
34
-
-
Equity at 12/31/21
4
6,666
505
(6,275)
899
73
5.1. General information
At the date of establishment of these financial statements, the simplified joint-stock company Ae-
lis Farma (hereinafter "Aelis Farma" or "the Company"), incorporated in October 2013, is a com-
pany domiciled in France, whose registered office is located in Bordeaux (33000) at 146, rue Léo
Saignat, and registered with the BORDEAUX Trade and Companies Register under number
797 707 627. Aelis Farma was a simplified joint-stock company until the General Meeting of Jan-
uary 11, 2022, which recorded its transformation into a public limited company with a board of di-
rectors.
Aelis Farma is a biotechnology company specializing in the research and development of treat-
ments for brain diseases.
It should be noted that the Company has not, since its creation, taken control of any other entity
within the meaning of IFRS 10 "Consolidated Financial Statements". These financial statements
are therefore not consolidated financial statements but individual financial statements of Aelis
Farma only. These accounts constitute an additional set of accounts compared to the historical
social accounts of Aelis Farma which are established according to French generally accepted ac-
counting principles.
On 04/01/2022, the Chairman approved and authorized the publication of the individual financial
statements prepared according to IFRS for the year ended 12/31/2021. These financial state-
ments have been prepared in connection with the listing of the Company's shares for trading on
the French regulated market.
5.2. Highlights of the year
Industrial partnership
In June 2021, the Company entered into an industrial partnership in the form of an exclusive li-
cense option agreement of the industrial property of AEF0117 in the field of cannabis-related dis-
orders, with Indivior PLC.
This agreement provides:
firstly, an exclusive license option granted to Indivior PLC, until the end of the phase 2b
clinical study for AEF0117. At the end of this study, Indivior PLC may or may not exercise
the option. During this period, Aelis Farma undertakes to make its best efforts to carry out
the phase 2b study and certain toxicity studies, and to communicate the results to Indivior
PLC. This option was remunerated by a payment at the signing of the contract of an
amount of 30 million USD, non-refundable and without retrocession to Indivior PLC.
if Indivior PLC exercises this option at the end of the phase 2b study, it will benefit from
an exclusive license allowing it to complete the development of the project, then to pro-
duce and market the drug. Aelis Farma would then license, in particular, the two patents
protecting AEF0117, research results, knowledge and know-how acquired since the start
of the project. Indivior PLC will then pay an amount of 100 million USD upon signing of
the license agreement then various sums at the achievement of technical, regulatory and
commercial milestones, up to 340 million USD as well as royalties on drug sales ranging
between 12 and 20%.
74
This agreement allows the Company to generate significant revenue over the period for the first
time. The treatment of this contract under IFRS 15 “Revenue from contracts with customers” is
specified below in Note 5.2 “Revenue”.
Research and Development activities
For compound AEF0117, 2021 was focused on:
the final validation of the results from our phase 2a clinical study in the United States,
which was submitted to the American drug agency, the FDA, in April 2021. This study
confirms the absence of significant side effects in cannabis drug addicts and provides the
first evidence of efficacy in humans for AEF0117;
development and validation with the FDA and our partner Indivior PLC of the protocol for
the next phase 2b study. This study coordinated by Columbia University (New York), will
involve 330 patients and 6 clinical centers over a period of 2 years, and will confirm the
effectiveness of AEF0117 as a treatment for cannabis use disorders;
launch of additional pre-clinical toxicity studies, and the production of new clinical batches
of the pharmaceutical product which will be used in the phase 2b clinical study.
For AEF0217, the Company's second drug candidate, targeting applications in the field of cogni-
tive deficits and in particular in the field of Down syndrome, 2021 was focused on:
regulatory filing to the Spanish Medicines Agency (AEMPS) for authorization to start
phase 1 studies in healthy volunteers;
production of technical and clinical batches of pharmaceutical products (dispersible tab-
lets) intended for phase 1 studies;
obtaining from the AEMPS the authorization to administer AEF0217 to humans on Sep-
tember 19, 2021;
initiation of the phase 1 clinical program (early October 2021). The results of the first co-
horts of healthy volunteers do not show any notable adverse effects and show good phar-
macokinetic characteristics of the compound;
launch of additional pre-clinical toxicity studies (phototoxicity and toxicity 6-9 months).
The upstream research program (Discovery program) was mainly focused on the mechanism of
action of CB1-SSi and on the characterization of new compounds.
5.3. General accounting rules and policies
5.3.1. Declaration of conformity
These financial statements have been prepared in connection with the listing of the Company's
shares for trading on the French regulated market.
These financial statements have been prepared in accordance with international accounting
standards IFRS in accordance with the principles defined by the IASB (International Accounting
Standards Board), as adopted by the European Union as at 31 December 2021. All of the stand-
ards adopted by the European Union can be consulted on the European Commission website:
75
The international framework includes IFRS (International Financial Reporting Standards), IAS (In-
ternational Accounting Standards), as well as their interpretations SIC (Standard Interpretations
Committee) and IFRIC (International Financial Reporting Interpretations Committee). There is no
difference impacting the Company between the standards used and the standards adopted by
the IASB whose application is mandatory for the year presented.
The accounting principles applied remain unchanged from those of the previous year, with the ex-
ception of the adoption of the following standards, applied since January 1, 2021:
amendments to IFRS 9, IAS 39, IFRS 7, IFRS 4 and IFRS 16 “Interest rate benchmark
reform, phase 2”
amendments to IFRS 16 “Covid-19-related rent relief beyond June 30, 2021”
These standards, amendments or interpretations have no significant impact on the consolidated
financial statements as of December 31, 2021.
In May 2021, IFRS-IC published the final decision “Attributing Benefit to Periods of Service” on
the application of IAS 19 “Employee Benefits”. This interpretation relates to certain post-employ-
ment benefits whose calculation is based on seniority, the latter being capped at a certain num-
ber of years of service. This interpretation recommends allocating the rights to indemnities gradu-
ally acquired by employees and therefore constituting the provision at the end of their career,
during the length of service capped by the scheme for calculating the indemnity.
The Company is affected by this new interpretation for the valuation of the provision for retire-
ment indemnities payable in France.
Indeed, the method historically applied by the Company consisted of a linear constitution of the
provision over the entire career of the employee, as soon as he/she joined the workforce, and not
over the length of service capped at the end of his/her career.
The consequences of this decision are to be analyzed as a change in accounting method within
the meaning of IAS 8 “Accounting methods, changes in accounting estimates and errors”.
The Company applied for the first time the method described by IFRS-IC for the valuation of the
provision for retirement benefits as of December 31, 2021, the date of the first closing since the
publication of the interpretation.
The Company has assessed the impact of this change on previous years and considers it not to
be significant. In accordance with IAS 8, it has therefore not carried out a retrospective restate-
ment of the financial statements.
The Company has not decided on the early application of any other standard, interpretation or
amendment. The standards, interpretations and amendments published with mandatory applica-
tion after December 31, 2021 that may have an impact on the Company's financial statements
are as follows:
amendments to IFRS 3: “Reference to the Conceptual Framework”;
amendments to IAS 16: “Tangible assets: Proceeds before intended use”;
amendments to IAS 37: “Onerous Contracts — Cost of Performing the Contract”;
amendments to IAS 1: “Classification of liabilities as current or non-current postpone-
ment of the effective date to January 2023”;
76
amendments to IAS 1 and the statement of practice in IFRS 2: “Disclosures about ac-
counting policies”;
amendments to IAS 8: “Definition of Accounting Estimates”;
amendments to IAS 12: “Deferred tax attached to assets and liabilities arising from the
same transaction”;
annual improvements to IFRS standards 2018-2020.
The Company does not expect any significant impacts on these accounts related to the applica-
tion of these new standards, interpretations or amendments.
5.3.2. Preparation basis
The financial statements have been prepared on a historical cost basis, except for the revaluation
of certain assets and financial instruments that have been measured at fair value at the end of
each reporting period, as explained in the accounting policies below. Historical cost is generally
based on the fair value of the consideration given in exchange for goods and services.
The Company considering this to be the presentation modality providing the most relevant relia-
ble information, pursuant to the option offered by IAS 1 "Presentation of Financial Statements",
presents its statement of income by function (destination) of expenses and not by nature of ex-
penses.
The financial statements provide comparative information with respect to previous periods.
Unless otherwise indicated, financial information is presented in thousands of euros without deci-
mal places, with the euro being the Company's presentation currency.
5.3.3. Critical accounting judgments and key sources of
uncertainty in estimates
The application of the Company's accounting policies, which are described in these notes to the
financial statements, requires management to make judgments, estimates and assumptions that
may materially affect the carrying amounts of assets and liabilities, equity and certain income and
expenses. These underlying estimates and assumptions are based on past experience and other
factors considered relevant. Actual results may differ from these estimates.
The underlying estimates and assumptions are regularly reviewed to ensure that they are rea-
sonable in light of the Company's history, economic conditions and information available to the
Company. Revisions to the accounting estimates shall be recognized in the period in which the
estimate is revised if the revision affects only that period, or in the period of the revision and in
subsequent periods if the revision has an impact on the period under review and on subsequent
periods.
The main estimates and assumptions that have been determined in the preparation of Aelis
Farma's financial statements concern:
the assessment of the fair value of share-based payments plans;
the assessment of the fair value of financial instruments granted to investors;
the assessment of the fair value of derivatives attached to bond issues;
77
the valuation of obligation for pension liabilities;
the term of the contracts to be used for the application of IFRS 16 to leases as well as the
determination of incremental borrowing rates;
the market rate used for the application of IAS 20 on repayable advances;
the recognition of deferred tax assets.
5.3.3.1. Fair value assessment of share-based payment plans
The Company has implemented a number of share-based payment plans (founders warrants
“BSPCE” and share purchase warrant “BSA” plans) granted to the Company's founders, directors
and employees. These plans fall within the scope of IFRS 2 "Share-based payments". The fair
value determined on the date of allocation of the shares is recognized as personnel expenses, in
return for an increase in equity, over the period during which the employees render services to
the Company.
The measurement of this fair value, based on the application of the Black and Scholes method,
takes into account the following factors: the price of the shares at the valuation date, the exercise
price of the instrument, the observed volatility, the expected maturity of the instruments, the turn-
over regarding the estimate of the number of instruments to be acquired, the risk-free interest
rate (based on government bonds) and an illiquidity discount. These factors are determined on
the basis of market data. The service acquisition and performance conditions attached to the
rights are not taken into account in the fair value assessment but reflected by adjusting the num-
ber of equity instruments and the acquisition period.
Observed volatility
The volatility of a share can be calculated implicitly or on the basis of an observation of historical
price changes.
In the absence of listed derivatives that would allow a satisfactory measure of implied volatility,
the volatility retained corresponds to the market volatility as calculated and published by A. Dam-
odaran (Stern NYU) for each date of allocation of the bonds.
Expected duration
In the context of the valuation of a share purchase warrant (BSA), it is customary to rely on the
exercise history of beneficiaries under similar instruments. In the absence of information, it is cus-
tomary to retain the half-exercise period (mid-maturity) i.e., the duration between the "grant date"
and the date corresponding to the middle of the operating window of the instruments.
In this case, the "grant date" corresponds to the date on which the two parties reached an agree-
ment, i.e., in practice the date of signature of the subscription form.
Risk-free interest rates
The risk-free rate used corresponds to the 1-year average of the TEC 10 rate, calculated on each
allocation date of the bonds (source: Banque de France). This rate reflects the actuarial return on
a Treasury bond over a 10-year horizon, which is the reference for risk-free investing.
Expected dividend yield
The Company has never declared or paid cash dividends and does not currently plan to pay cash
dividends for the foreseeable future.
78
Probability of exercise of the warrants
As the exercise of the warrants is subject to tranche objectives, the Company has determined the
likelihood that the conditions for the exercise of the warrants will be met for each of the tranches.
Discount "Bad Leaver"
In order to protect financial investors from the premature departure of a key man from the Com-
pany, "Bad Leaver" clauses were put in place in the Shareholders' Agreement of December 22,
2017. These clauses concern founding employees as well as researchers under the status of sci-
entific competition. For the warrants covered by the "Bad Leaver" clauses, the Company applied
a discount to the value of the warrants to take into account the loss of value induced by an early
exercise of the warrant by their beneficiary.
Illiquidity discount
Compared to the securities of comparable companies in the volatility sample, the liquidity of the
warrants is not total. This justifies the application by the Company of an illiquidity discount to the
value of the warrants.
Share-based payments are the subject of Note 7 "Share-based payments" in Note 4.7.
5.3.3.2. Fair value assessment of financial instruments granted to
investors
The Company determines the fair value of the warrants on the date of issue of the Shares with
Equity Warrants (ABSA – Actions à Bons de Souscription d’Actions) using the Black-Scholes val-
uation model.
The Black-Scholes model requires consideration of different assumptions, including observed vol-
atility, expected duration, risk-free interest rate, and dividend yield.
Observed volatility
The volatility of a share can be calculated implicitly or on the basis of an observation of historical
price changes.
In the absence of listed derivatives that would allow a satisfactory measure of implied volatility,
the volatility retained corresponds to the market volatility as calculated and published by A.Damo-
daran (Stern NYU).
Expected duration
In the context of the valuation of a share purchase warrant (BSA) it is customary to rely on the ex-
ercise history of the beneficiaries in respect of similar instruments. In the absence of information,
it is customary to retain the half-period of exercise (mid-maturity) namely the duration between
the "grant date" and the date corresponding to the middle of the operating window of the instru-
ments. In this case, the "grant date" corresponds to the date on which the two parties reached an
agreement, i.e., in practice the date of the minutes of the general meeting of the 2017 ABSA B
issue.
Risk-free interest rates
The risk-free rate used corresponds to the 1-year average of the TEC 10 rate, calculated on
20/07/2017 (source: Banque de France). This rate reflects the actuarial return on a Treasury
bond over a 10-year horizon, which is the benchmark for risk-free investing.
79
Expected dividend yield
The Company has never declared or paid cash dividends and does not currently plan to pay cash
dividends for the foreseeable future.
Probability of exercise of warrants
As the exercise of the warrants is subject to objectives, the Company has determined the likeli-
hood that the conditions for the exercise of the warrants will be met.
5.3.3.3. Valuation of the fair value of hybrid debt and derivatives
attached to convertible bonds and, where applicable, attached
derivatives
Convertible bond (OCA 2017)
The fair value of the convertible bond conversion option (OCA 2017) is measured by the differ-
ence from the present value of the estimated future coupons and principal repayment by using,
for the discount, the market rate based on the financing of companies with a similar rating and for
an equivalent maturity.
The use of market rates requires the consideration of different assumptions, including the Com-
pany's rating and the use of yield curves.
Company Rating
In order to determine the market rate on the grant date of the Convertible Bonds (OCA), i.e., July
12, 2017, the Company simulated the financial rating that could be granted to it by a leading
credit rating company.
Market rate
On the basis of the bonds issued in euro on the grant date of the Bonds Convertible into Shares
(OCA), i.e., July 12, 2017, with a maturity of 5 years, the Company has determined the market
rate to be used for the discount.
Bonds convertible into shares with equity warrants (OCABSA 2019)
The fair value of derivatives attached to convertible bonds to share with equity warrant
(OCABSA) is measured using a Black-Scholes model to which a probability of exercising the con-
version option and an illiquidity discount are applied.
The Black-Scholes model requires consideration of different assumptions, including observed vol-
atility, expected duration, risk-free interest rate, and dividend yield.
Observed volatility
The volatility of a share can be calculated implicitly or on the basis of an observation of historical
price changes.
In the absence of listed derivatives that would allow a satisfactory measure of implied volatility,
the volatility retained corresponds to the market volatility as calculated and published by A.Damo-
daran (Stern NYU).
Expected duration
In the context of the evaluation of a conversion option, it is customary to rely on the exercise his-
tory of beneficiaries under similar instruments In the absence of information it is customary to re-
tain the half-exercise period (mid-maturity) i.e. the duration between the "grant date" and the date
80
corresponding to the middle of the operating window of the instruments. In this case, the "grant
date" corresponds to the date on which the two parties reached an agreement, either in practice
the date of subscription of the bond convertible into a share with equity warrant (OCABSA) or Au-
gust 26, 2019.
Risk-free interest rates
The risk-free rate used corresponds to the 1-year average of the TEC 10 rate, calculated on 26
August 2019 (source: Banque de France). This rate reflects the actuarial return on a Treasury
bond over a 10-year horizon, which is the benchmark for risk-free investing.
Expected dividend yield
The Company has never declared or paid cash dividends and does not currently plan to pay cash
dividends for the foreseeable future.
Probability of conversion of the option
As the exercise of the conversion option is subject to phased clinical validation objectives, the
Company has determined the likelihood that the conditions for conversion of the option will be
met over the life of the option.
5.3.3.4. Valuation of obligation for pension liabilities
The Company's obligation related to statutory or contractual retirement benefits has been as-
sessed at each closing. The calculation is based on the actuarial method of the projected cred-it
units incorporating assumptions of changes in wages, age of departure, presence, mortality and
at the balance date which are described in Note 4.8 "Contingent provisions and liabilities".
5.3.3.5. Term and incremental borrowing rate for leases (IFRS)
In applying IFRS 16, the Company uses the following estimates and judgments:
determination of the term of a lease agreement: the lease term taken into consideration
corresponds to the non-cancellable period of each contract, to which are added all the ex-
tension options that the Company has the reasonable certainty of exercising, and all the
termination options, which the Company has the reasonable certainty not to exercise;
these estimates take into account the impact of the November 2019 IFRS-IC decision on
the leases term;
determination of the discount rate: in cases where the implicit rate of the contract is not
easily determinable, the discount rate used corresponds to the incremental borrowing rate
on the date of commencement of the contract. This rate is determined from the Compa-
ny's marginal borrowing rate. The rates used were determined to reflect the rate that
would be obtained for a loan with a similar payment profile (i.e., a rate reflecting the dura-
tion of the contract).
5.3.3.6. Market rate used for the application of IAS 20 on repayable
advances
The market rate used for the application of IAS 20 corresponds to the marginal borrowing rate at
the start date of the contract. This rate is determined from the Company's marginal borrowing
81
rate. The rates used were determined to reflect the rate that would be obtained for a loan with a
similar payment profile (i.e., a rate reflecting the duration of the contract).
5.3.3.7. Recognition of deferred tax assets
Deferred tax assets are recognized only when their recovery is considered sufficiently likely as a
result of future taxable profits or when carry-forward losses can be set off against taxable tem-
poral differences. The deferred tax assets are limited, where applicable, to take into account the
cap on the deficit attributable annually if that cap is imposed by the entity's tax legislation.
5.4. Foreign currency transactions
5.4.1. Conversion of financial statements denominated in foreign
currencies
As part of the preparation of the Company's financial statements, transactions denominated in a
currency other than the entity's operating currency (foreign currency) are accounted for using the
exchange rate in effect on the date of the transaction. At each balance date, monetary assets and
liabilities denominated in foreign currency shall be converted using the rate in effect on that date.
Non-monetary items recognized at fair value and denominated in foreign currency are translated
using the exchange rates in effect on the date on which that fair value was determined. Non-mon-
etary items that are valued at historical cost and denominated in foreign currency are not con-
verted.
Foreign exchange differences are recognized as net income in the period in which they occur, ex-
cept in special cases not concerning the Company.
5.4.2. Hedge accounting
At the time of inception of the hedging relationship, the Company prepares documentation de-
scribing the relationship between the hedging instrument and the hedged item as well as its risk
management objectives and strategy for entering into various hedging transactions.
Furthermore, when creating the hedge and regularly thereafter, the Company indicates whether
the hedging instrument is highly effective in offsetting variations in the cash flows of the hedged
item attributable to the hedged risk, that is to say when the hedging relationship satisfies all of the
following hedge effectiveness constraints:
there is an economic link between the hedged item and the hedging instrument;
credit risk does not have a dominant effect on the changes in value resulting from this
economic link;
the hedge ratio of the hedging relationship is equal to the ratio between the quantity of the
hedged item that is actually hedged by the Company and the quantity of the hedging in-
strument that the Company actually uses to hedge this quantity of the covered item.
In 2021, the Company chose to set up auto-hedging in dollars following the receipt of the $30 mil-
lion for the license option contracted with Indivior PLC. Thus, these funds in dollars will be used
to finance the future costs of the research program carried out in this currency (studies related to
AEF0117 in the United States), constituting thereby a natural exchange rate hedge.
82
Thus, the revaluation at the closing rate of the cash account in USD resulted in:
for the part of the cash balance intended to cover future research and development oper-
ations in foreign currencies, as established based on the Company's budget, the recogni-
tion in Comprehensive Income of the part of the variation thus determined; this amount
will be reported in the income statement when the research and development operations
thus covered are settled;
for the balance in USD that does not hedge future transactions, an exchange rate varia-
tion was recognized in the income statement.
As of December 31, 2021, the Company thus revalued its cash in foreign currency (USD) and
recognized, in comprehensive income, an income of €527,000.
5.5. Notes to the statement of financial position
5.5.1. Intangible assets
Initially, separately acquired intangible assets are measured at cost.
The Company's intangible assets mainly include royalties upon completion of technical mile-
stones paid in accordance with the license agreements that bind Aelis Farma to the owners of the
patents. In accordance with IAS 38, these amounts will be amortized as soon as they generate
economic benefits.
Establishment and research costs are directly recognized as expenses in the year in which they
are incurred.
Development expenses are recognized as intangible assets if the Company is able to demon-
strate verification of all of the following criteria:
the technical feasibility necessary for the completion of the intangible asset with a view to
its commissioning or sale;
its intention to complete the intangible asset and to use or sell it;
its ability to use or sell the intangible asset;
how the intangible asset will likely generate future economic benefits;
the availability of appropriate technical, financial and other resources to complete the de-
velopment and use or sell the intangible asset and;
the ability to reliably estimate the expenses attributable to the intangible asset during its
development.
Otherwise, these costs constitute expenses. Currently, the Company does not record any devel-
opment expenses as intangible assets. Indeed, due to the risks and uncertainties associated with
regulatory approvals and the research and development process, the criteria set out in IAS 38 are
not met, and in particular the criterion concerning technical feasibility. Thus, expenses incurred
before meeting these criteria are recorded as expenses, on the line "Research and Development
expenses".
After their initial recognition, intangible assets will be recognized on a cost basis and amortized
on a straight-line basis over their expected useful life.
83
Finally, it should be noted that the Company has not carried out, since its creation, any business
combination within the meaning of IFRS 3 "Business Combinations".
In each of the periods presented, the Company's intangible assets mainly include royalties upon
completion of technical milestones paid in accordance with the license agreements that bind Aelis
Farma to the owners of the patents.
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN GROSS VALUES IN 2020
In thousands of euros
12/31/19
Acquisitions
Disposals
12/31/20
Concessions, patents and software
31
30
-
61
Total intangible assets
31
30
-
61
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN GROSS VALUES IN 2021
In thousands of euros
12/31/20
Acquisitions Disposals 12/31/21
Concessions, patents and software
61
30
-
91
Total intangible assets
61
30
-
91
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN DEPRECIATION AND AMORTIZATION
IN 2020
Depreciation,
amortization
In thousands of euros
12/31/19
Reversals 12/31/20
and
impairment
Concessions, patents and software
0
(0,5)
-
(0,5)
Total intangible assets
0
(0,5)
-
(0,5)
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN DEPRECIATION AND AMORTIZATION
IN 2021
Depreciation,
amortization
In thousands of euros
12/31/20
Reversals 12/31/21
and
impairment
Concessions, patents and software
(0,5)
0
-
(0,5)
Total intangible assets
(0,5)
0
-
(0,5)
5.5.2. Tangible assets and rights of use related to lease contracts
5.5.2.1. Tangible assets
Separately acquired tangible assets are initially measured at cost, which includes all expenses
directly related to the acquisition. Subsequent capital expenditures are recognized as expenses
when incurred, except those incurred to extend the life of the asset.
84
Constructions, materials and tools, furniture and fittings are depreciated on a straight-line basis
over their useful life. The useful lives used by category of capital assets are as follows:
Other tangible assets: 2 to 5 years.
5.5.2.2. Leases
Lease contracts that give the lessee control over the use of an identified asset for a given period
of time in exchange for consideration fall within the scope of IFRS 16. The Company recognizes
the assets on the balance sheet in the form of a right of use in counterpart of a lease liability for
all leases with the exception of contracts with a term of less than twelve months and contracts for
low-value assets in accordance with the exemptions offered by the standard.
Lease liability is initially determined at the present value of unpaid lease payments at that date,
discounted to the implied interest rate of the lease if such rate is readily available or, failing that,
to the Company's incremental borrowing rate. Lease payments include fixed payments, variable
payments based on an index or rate, and payments arising from reasonably certain options to be
exercised.
After the initial measurement, the lease liability is reduced by the payments made and increased
by the interest expense. It is remeasured to reflect any change in future lease payments in the
event of a new negotiation with the lessor, a change in an index or rate, or in the event of a re-
estimation of options. When the lease liability is reassessed, the corresponding adjustment is re-
flected in the right of use, or in profit or loss if the right of use is already reduced to zero in the
case of a reduction in the rental perimeter.
The originally determined right of use includes the initial lease liability, initial direct costs and any
obligations to renovate the asset, less the benefits granted by the lessor.
The rights of use are amortized over the term of the contract. In the income statement, deprecia-
tion and amortization expenses are recognized in operating income and interest charges in finan-
cial income. The tax impact of this restatement is taken into account through the recognition of
deferred taxes.
The lease term retained corresponds to the non-cancellable period, the periods covered by an
extension option whose exercise is reasonably certain, as well as the periods covered by a termi-
nation option whose non-exercise is reasonably certain.
Finally, it should be noted that the Company does not intervene in lease contracts as a lessor.
Property, plant and equipment mainly include:
rights of use regarding real estate;
laboratory equipment and tools used as part of the Company's “Discovery” activity.
85
TANGIBLE CAPITAL ASSETS: DECOMPOSITION AND CHANGE IN 2020 GROSS VALUES
In thousands of euros
12/31/19 Acquisitions Disposals 12/31/20
Other tangible assets
33
33
5
5
-
-
-
-
-
-
38
38
Sub-total tangible assets
Rights-of-use - real estate
Sub-total rights of use tangible assets
Total tangible assets
103
103
136
103
103
141
-
5
TANGIBLE CAPITAL ASSETS: DECOMPOSITION AND CHANGE IN 2021 GROSS VALUES
In thousands of euros
12/31/20 Acquisitions Disposals 12/31/21
Technical installations, equipment and tools
Other tangible assets
-
125
58
183
-
-
(7)
(7)
-
125
88
38
Sub-total tangible assets
38
214
103
103
316
Rights-of-use - real estate
103
103
141
Sub-total rights of use tangible assets
Total tangible assets
-
-
183
(7)
PROPERTY, PLANT AND EQUIPMENT: DECOMPOSITION AND CHANGE IN DEPRECIATION 2020
Depreciation,
amortization
In thousands of euros
12/31/19
Reversals 12/31/20
and
impairment
Technical installations, equipment and tools
Other tangible assets
-
-
-
4
4
-
-
(20)
(20)
(42)
(42)
(63)
(12)
(12)
(21)
(21)
(34)
(29)
(35)
(64)
(64)
(92)
Sub-total tangible assets
Rights-of-use - real estate
Sub-total rights of use tangible assets
Total tangible assets
-
4
PROPERTY, PLANT AND EQUIPMENT: DECOMPOSITION AND CHANGE IN DEPRECIATION 2021
Depreciation,
amortization
In thousands of euros
12/31/20
Reversals 12/31/21
and
impairment
Technical installations, equipment and tools
Other tangible assets
-
(4)
-
7
7
-
(4)
(31)
(35)
(85)
(85)
(120)
(29)
(29)
(64)
(64)
(92)
(10)
(14)
(21)
(21)
(35)
Sub-total tangible assets
Rights-of-use - real estate
Sub-total rights of use tangible assets
Total tangible assets
-
7
86
Amounts recognized as cash flows under lease contracts
Cash outflows attributable to leases amounted to €26,500 at 31 December 2021 and €26,500 as
at 31 December 2020.
There are no amounts presented in operating expenses corresponding to leases benefiting from
short-term or low-value exemptions of the underlying asset.
5.5.3. Impairment of non-financial assets
IAS 36 "Impairment of assets" specifies that an asset is to be impaired when its carrying amount
is greater than its recoverable amount. The recoverable amount of an asset or group of assets is
the greater of its fair value less costs of disposals and its value in use.
The impairment test consists of comparing the recoverable amount of a non-current asset to its
carrying value. If applicable, the asset is impaired to its recoverable amount by recognizing the
impairment loss.
Assets with an indefinite useful life or which are not yet ready for commissioning, and which are
therefore not yet depreciated are subject to an annual impairment test.
Assets with a fixed useful life are depreciated and are subject to an impairment test only if there
is an internal or external evidence of a loss of value.
The Company did not identify any impairment losses as a result of the completion of the impair-
ment tests for unamortized capital assets.
The Company considers that there is no indication of impairment loss on other non-current assets
between January 1, 2021, and December 31, 2021.
5.5.4. Receivables and deferred expenses
Trade receivables are initially recognized at their transaction price (as defined in IFRS 15). They
are measured at amortized cost less expected losses over the life of the receivable according to
the simplified approach provided for in IFRS 9; as they do not include a significant financing com-
ponent given short settlement deadlines. The valuation of expected credit losses is carried out in
particular by taking into account the history of credit losses and their age.
Aelis Farma did not achieve significant turnover in the fiscal year 2020. In the fiscal year 2021,
the revenue generated by the license option contract signed with Indivior PLC was collected in
the month the contract was signed (June 2021). In this context, on each balance sheet presenta-
tion date of these financial statements, Aelis Farma does not present any significant customer re-
ceivables.
Other current assets are mainly comprised of receivables related to Research Tax Credits, grant
receivables, VAT and deferred expenses (see also Note 5.3 "Other ordinary income").
Prepaid expenses are determined in accordance with the principles of separation of fiscal years.
They correspond in particular to research and development contracts with successive execution.
When the effective date of the contract does not coincide with that of the financial year, the
amount paid, corresponding to the fraction of the services which will only be performed during a
subsequent financial year, is entered as a prepaid expense. As of December 31, 2021, the costs
87
incurred in the 2021 financial year, directly related to the capital increase during the IPO,
amounted to €421,293.
OTHER CURRENT ASSETS
In thousands of euros
12/31/21
12/31/20
Employee and social charges receivables
Tax receivables
0
368
-
0
108
-
Group current account
Prepaid expenses
1,607
891
352
81
57
Research tax credit
Grant receivables
692
538
2
Other
Total other current assets
3,298
1,397
5.5.5. Cash and cash equivalents
Cash and cash equivalents include short-term cash and investments (maturity of up to 3 months),
which are highly liquid and are easily convertible into a known amount of cash and are subject to
a negligible risk of a change in value.
On each balance sheet date, the item is only composed of cash.
5.5.6. Equity and earnings per share
The Company's capital is composed of ordinary shares. Ordinary shares are shares conferring
voting rights and financial rights in proportion to the share of capital they represent.
As at December 31, 2021, the Company's registered share capital consisted of 399,698
ordinary shares.
As at December 31, 2020, the Company's registered share capital consisted of 399,480
ordinary shares.
All shares have a nominal value of €0.01 and are fully paid-up.
5.5.6.1. Share capital and issue premium
EVOLUTION OF SHARE CAPITAL AND ISSUE PREMIUM
Number of
In euros
shares
Share capital
Share premiums
As at December 31, 2019
Shares issued during the period
Allocation of income
399,480
3,995
1,051,440
-
-
-
-
-
(118,550)
2,069
Warrants subscription (BSA)
As at December 31, 2020
Shares issued during the period
Allocation of income
-
-
399,480
3,995
934,959
12,801
(934,959)
22,249
35,049
218
2
-
-
-
Warrants subscription (BSA)
At December 31, 2021
-
399,698
3,997
88
This number does not include warrants ("BSA") and founders warrants ("BSPCE") granted to cer-
tain employees, strategic consultants/collaborators and members of the Board of Directors of the
Company and not yet exercised see Note 4.5 "Share-based payments" for details of these
transactions.
5.5.6.2. Evolution of share capital
The change in the share capital over the 2021 financial year is linked to the exercise of share
subscription warrants (capital increase), as well as the allocation of share subscription warrants.
5.5.6.3. Allocation of profit and dividends
Allocation of loss for financial year 2020
The Shareholders' Meeting of 25 June 2021 decided to allocate the loss for the 2020 financial
year in the amount of €2,783,646 as deductions from the issue premium of - €934,958 and re-
tained earnings of - €1,848,688.
5.5.6.4. Characteristics of Equity Warrants (BSAs) recognized as equity
As part of the capital increase carried out by the Company in December 2017, 81,949 ABSA B
Tranche 1 were issued. Each of its ABSA B Tranche 1 carried a BSA Tranche 2 and a BSA
Tranche 3, i.e., 81,949 BSA Tranche 2 and 81,949 BSA Tranche 3 respectively.
As parity is fixed for all BSAs, they were recognized as equity instruments at the date of issue.
RECOGNIZED EQUITY BSAS
Fair value
of the
Subs-
cription
price
(€)
instruments
Maturity (pre-
Illiqui-
dity
dis-
Nb
Instrument instru
ments
Share
Price
(€)
Subs-
cription
Date
Probabi-
lity of
success
Fair
value
(€K)
Date
discount
and
count
probability
of success)
BSA
81 949
Tranche 2
46,98
46,98
46,98
46,98
20/12/17 31/08/19
20/12/17 31/08/20
317
165
66 %
50 %
20
20
167
66
BSA
81 949
Tranche 3
During the additional capital increase authorized by the Extraordinary General Meeting of July 19,
2019, ABSAs were issued. To each ABSA is attached a warrant for a BSA R 2017 (ratchet).
5.5.6.5. Earnings per share
Pursuant to IAS 33 "Earnings per share", basic earnings per share is calculated by dividing the
earnings attributable to holders of Aelis Farma shares by the weighted average number of ordi-
nary shares outstanding during the period. Diluted earnings per share are determined by adjust-
ing the earnings attributable to the Company's shareholders and the weighted average number of
ordinary shares outstanding for the effects of all potentially dilutive ordinary shares.
89
If the inclusion of instruments giving entitlement to capital on a deferred basis (BSA, BSPCE,
convertible bonds, free shares, etc.) generates an anti-dilutive effect, these instruments are not
taken into account.
BASIC EARNINGS PER SHARE
Calculation components
12/31/21
12/31/20
Net income (loss)
573,505
399,500
1,44
(2,086,282)
399,480
(5,22)
Weighted average number of ordinary shares in issue
Basic earnings (loss) per share (€)
DILUTED EARNINGS PER SHARE
Calculation components
12/31/21
Net income (loss)
573,505
399,500
109,409
508,909
3,87
Weighted average number of ordinary shares in issue
Potential number of dilutive shares (1)
Weighted average number of ordinary shares in issue (diluted)
Diluted earnings (loss) per share (€)
(1) Dilutive instruments consist of 40,441 convertible bonds, granted in 2017 and 2019, and for the balance of
BSPCE and BSA, presented in Note 4.7 Share-based payments.
5.5.7. Share-based payments
Aelis Farma has awarded to some of its employees and senior executives founders warrants
(BSPCE) and equity warrants (BSA). These transactions are settled in equity instruments.
In accordance with IFRS 2 "Share-Based Payment", these plans are recognized as expenses
over the vesting period of the associated rights by reference to their fair value determined at the
grant date. This expense is recorded as personnel costs in return for equity. The fair value of the
BSA and BSPCE awarded is determined by applying the Black and Scholes model.
90
5.5.7.1. Details of the plans
BSA PLANS (EQUITY WARRANTS)
Name
BSA 2017
BSA 2018
BSA 2019
BSA 2020
BSA 2021
Instruments
Ordinary shares Ordinary shares Ordinary shares Ordinary shares
Ordinary shares
1 500 (1 to 1)
Number of in-
struments
800 (1 to 1)
150 (1 to 1)
600 (1 to 1)
2,400 (1 to 1)
Strategic
Consultants/
Collaborators
06/27/2018
Strategic
Consultants/
Collaborators
10/23/2020
Strategic
Consultants/
Collaborators
04/29/2021
Independent
Director
Independent
Director
Beneficiaries
Award date
12/18/2018
02/28/2019
Per monthly
instalment
according to the
timetable indi-
cated for each
beneficiary
Per monthly
instalment until
12/20/21
Per monthly
instalment until
02/27/23
Per monthly
instalment until
04/29/2021
Vesting
period
Acquired
immediately
Condition of
presence
Yes
12/27/2027
€46.98
Yes
12/20/2027
€46.98
Yes
12/20/2027
€46.98
Yes
12/23/2030
€58.73
Yes
12/23/2030
€58.73
Exercise
deadline
Exercise
price
Issue price
€4.50
€4.50
€4.50
€8.90
€8.90
BSPCE PLANS (FOUNDERS WARRANTS)
BSPCE
2021
BSPCE
2017
BSPCE
2019
BSPCE
2020
BSPCE
2020
BSPCE
2020
Name
BSPCE
Ordinary
shares
40
Ordinary
shares
Ordinary
shares
9 400
Ordinary
shares
1 000
Ordinary
shares
Ordinary
shares
4 400
Ordinary
shares
1 789
Instruments
Number of
15 000
5 200
instruments
(1 to 1)
(1 to 1)
Employees
or
corporate
officers
(1 to 1)
(1 to 1)
(1 to 1)
(1 to 1)
Employees
or
corporate
officers
(1 to 1)
Chairman
of the
Board and
employees
Beneficiaries Employees
Employee
Employee
Employee
Date of
award
06/16/2017 06/28/2018 02/28/2019 02/21/2020 02/21/2020 10/23/2020 04/29/2021
Per
Per
monthly
instalment
according
to the
timetable
indicated
for each
monthly
instalment
according
to the
timetable
indicated
for each
Per
Per
By monthly
instalment
until
monthly
instalment
until
Vested
immedi-
ately
monthly
instalment
until
Vesting
period
30 months
02/21/2024
12/20/2021
12/20/2021
beneficiary beneficiary
Condition of
presence
Exercise
deadline
Exercise
price
Yes
Yes
Yes
Yes
Yes
Yes Yes
06/13/2023 12/20/2027 12/20/2027 12/20/2027 12/20/2027 12/23/2030 12/23/2030
€25.34
€46.98
€46.98
€58.73
€58.73
€58.73
€58.73
Issue price
N/A
N/A
N/A
N/A
N/A
N/A
N/A
91
CHARACTERISTICS OF PLANS BENEFITING FROM THE IFRS 1 EXEMPTION
Characteristics of IFRS 1-exempted plans
Type
Grant date
Total number of
Maximum
awarded share sub- Maturity date
scription warrants
Exercise price
acquisition period in
year
BSA
12/19/2013
355
12/31/2023
€400.00
immediately
TOTAL
355
CHARACTERISTICS OF PLANS AND VALUATION HYPOTHESIS
Characteristics of the plans
Initial
valua-
tion of
the
plan in
€K (1)
Total
number
of
granted
warrants
Underly-
ing
share
value
Grant
date
Maximum
Type
Maturity
date
Exercise
price
acquisition
period in
year
Risk-
free rate
Volatility
(euros)
BSA
2017
BSA
2018
BSA
2019
BSA
2020
BSA
2021
06/27/2018
12/18/2018
03/19/2019
10/23/2020
04/29/2021
800
150
600
12/20/2027
12/20/2027
12/20/2027
€46.98
€46.98
€46.98
€58.73
4 years
€46.98 73.16 % 0.74 %
2
immediate €46.98 73.16 % 0.74 %
1
4 years
4 years
€56.66 61.80 % 0.71 %
€58.73 62.07 % -0.10 %
10
35
2,400 10/23/2030
1,500 10/21/2030
€58.73
€25.34
€46.98
4 years
2.5 years
4 years
€173.77 45.63 % -0.19 %
€40.04 61.07 % 0.62 %
€46.98 73.16 % 0.74 %
160
68
BSPCE * 06/13/2017
40
06/13/2023
BSPCE
2017
06/27/2018 15,000 12/20/2027
92
BSPCE
2019
03/04/2019
02/21/2020
10/21/2020
04/29/2021
9,400 12/20/2027
6,200 12/20/2027
4,400 12/20/2027
€46.98
€58.73
€58.73
€58.73
4 years
4 years
4 years
4 years
€56.66 61.80 % 0.71 %
€58.73 62.07 % 0.02 %
€58.73 62.07 % -0.10 %
€173.77 45.63 % -0.19 %
159
125
72
BSPCE
02.2020
BSPCE
10.2020
BSPCE
04.2021
1,789 10/21/2030
179
TOTAL
42,279
903
(*) amounts expressed after change in Capital Parity
(1) Black & Scholes model
92
EVOLUTION OF THE NUMBER OF WARRANTS OUTSTANDING 2021
Maximum
number of
shares
that can
be sub-
Number of outstanding warrants
Type
Grant date
Exer-
cised
12/31/2020 Granted
Obsolete 12/31/2021
scribed for
BSA
12/19/2013
06/27/2018
12/18/2018
03/19/2019
10/23/2020
04/29/2021
06/13/2017
06/27/2018
03/04/2019
02/21/2020
02/21/2020
04/29/2021
315
800
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
315
800
31,500
BSA 2017
BSA 2018
BSA 2019
BSA 2020
BSA 2021
BSPCE
800
150
150
150
600
600
600
2,400
-
2,400
1,282
20
2,400
1,282
2,000
15,000
3,917
6,200
4,400
1,789
70,038
1,500
218
20
-
-
BSPCE 2017
BSPCE 2019
BSPCE02.2020
BSPCE10.2020
BSPCE 2021
TOTAL
15,000
3,917
6,200
4,400
-
-
-
15,000
3,917
6,200
4,400
1,789
36,873
-
-
-
-
-
-
-
-
-
-
-
1,789
3,289
33,802
218
EVOLUTION OF THE NUMBER OF WARRANTS AND WEIGHTED AVERAGE EXERCICE PRICE
12/31/2021
12/31/2020
Warrants depending on the
period
Weighted
Weighted
average
exercise price
Number of
options
Number of
options
average
exercise price
Outstanding at opening
Obsolete during the period
Exercised during the period
Granted during the period
Outstanding at closing
Exercisable at closing
3, 802
0
€54.78
€0
26,285
-5,483
0
€51.19
€46.98
€0
- 218
3,289
36,873
28,632
€58.73
€58.73
€55.11
€54.13
13,000
33,802
19,786
€58.73
€54.78
€54.51
The share-based payment expense recorded as personnel expenses is disclosed in Note 5.6 and
represents the following amounts:
93
EXPENSE RELATED TO SHARE-BASED PAYMENTS
In thousands of euros
2021
2020
BSA 2017
-
-
1
-
BSA 2018
BSA 2019
4
4
1
BSA 2020
31
140
-
BSA 2021
BSPCE
-
BSPCE 2017
BSPCE 2019
BSPCE 02.2020
BSPCE 10.2020
BSPCE 2021
Share-based payments
6
18
54
61
34
-
59
36
168
443
172
Given the Company's anticipated IPO, the vesting period relating to the various share-based pay-
ment instruments was reviewed, leading to the accelerated recognition of the remaining expense.
5.5.8. Provisions and contingent liabilities
5.5.8.1. Provisions
A provision is recognized when there is a legal or constructive obligation resulting from past
events, when it is likely or certain that it will result in an outflow of resources to third parties and
when the amount can be estimated reliably.
Provisions are broken down into current and non-current liabilities according to the expected ma-
turity and assessed taking into account the most likely assumptions at the reporting date.
To date, the Company does not recognize any provision other than its obligations relating to pen-
sions.
5.5.8.2. Contingent liabilities
A contingent liability is:
a possible obligation resulting from past events and whose existence will only be con-
firmed by the occurrence (or not) of one or more uncertain future events that are not fully
under the control of the Company.
a present obligation that is not recognized as it is not likely that an outflow of resources
representative of economic benefits is necessary to extinguish the obligation or, in rare
cases, as the amount of the obligation cannot be assessed with sufficient reliability.
To date, the Company has not identified any contingent liabilities.
94
5.5.8.3. Pension commitments
The Company's French employees receive pension benefits provided for by law in France. Post-
employment benefits are subject to two different regimes:
payment of retirement pensions by social security institutions corresponding to defined
contribution schemes. They are characterized by defined contributions paid to external
bodies. Under these schemes, the Company will have no legal or constructive obligation
to pay additional contributions if the organization does not have sufficient assets to pro-
vide all benefits corresponding to the services rendered by employees during the relevant
period and previous periods. These contributions are recognized as expenses in the year
in which the services are rendered.
a retirement allowance, paid by the Company to employees upon their retirement corre-
sponding to a defined benefit plan. These are schemes for which the Company is obliged
to pay the agreed benefits to its active and former staff members. As the Company does
not have plans assets, the entire commitment is recorded as a liability for its present
value.
Pension obligations and similar obligations are valued at the end of each financial year for the
present value of the Company's future obligations using the projected credit unit method. The
amounts of future payments are assessed on the basis of assumptions with respect to salary in-
creases, age of retirement, mortality and turnover. They are then discounted to their present
value using the interest rates on the long-term bonds of tier one private issuers and with a dura-
tion corresponding to the estimated average duration of the assessed plan. The assumptions
used for the periods presented are detailed below.
Actuarial gains and losses resulting from changes to calculation assumptions and adjustments
related to experience are recognized in other comprehensive income.
The net expense for the financial year, corresponding to the current service cost, plus the possi-
bly past service cost, is recognized in operating expenses.
The interest cost on the net defined benefit liability (or asset) is included in net financial income
(expense) and corresponds to the impact of unwinding the discount on the obligations
RETIREMENT OBLIGATIONS AND SIMILAR LIABILITIES: ACTUARIAL HYPOTHESES
Valuation assumptions
12/31/21
12/31/20
Pharmaceutical
industry
Pharmaceutical
industry
Labour agreement
Discount rate (taux IBOXX Corporates AA)
Wage increase rate
0.98 %
2.00 %
37 %
0.34 %
2.00 %
37 %
Employer social expenses rate
Staff turn-over
Low
Low
Mortality table
Insee 2019
Insee 2019
65-67
full pension
65-67
full pension
Retirement age
95
CHANGE IN PENSION OBLIGATION
Commitment variation (euros)
12/31/21
12/31/20
Commitment at opening
Current service cost
Interest expense
110,238
82,823
24,231
24,623
375
638
Staff entries effect
Staff transfers effect
Staff exits effect
-
-
-
-
-
-
Allocation of the impact of the change in regulations at 31/31/20 on
equity at 12/31/21
(33,590)
Actuarial gains or losses
Benefits paid
(262)
-
2,154
-
Commitment at closing
100,992
110,238
Sensitivity of pension obligations to actuarial assumptions
The discount rate assumption is the main actuarial assumption with a significant impact on the
amount of the commitment. The table below shows the impact of a 0.5 point increase in the dis-
count rate. Given the current context, a rate cut scenario is not considered plausible.
SENSITIVITY OF PENSION OBLIGATIONS TO ACTUARIAL ASSUMPTIONS
Rate
Provision
Var.
Real (R)
Date
Real (R)
(R) +0,5pt
Real (R)
(R) +0,5pt
12/31/20
12/31/21
0.34 %
0.98 %
0.84 %
1.48 %
110,238
100,992
99,661
85,340
(10,577)
15,632
Information on the maturity profile of the defined benefit obligation
In view of its specific characteristics (low seniority, limited staff, age of beneficiaries relatively dis-
tant from retirement), the Company is not in a position to develop a reliable estimate of the pay-
ment schedule for defined benefit obligations.
5.5.9. Financing and financial instruments
The Company recognizes a financial asset or liability when it becomes a party to the contractual
provisions of the instrument in accordance with IFRS 9 "Financial Instruments".
A financial asset (except a trade receivable with no significant financing component) or a financial
liability is initially measured at fair value plus or minus, for an item that is not at fair value through
profit of loss, transaction costs that are directly attributable to its acquisition or issuance. A trade
receivable without a significant financing component is initially measured at its transaction price
within the meaning of IFRS 15.
5.5.9.1. Financial assets
At the time of initial recognition, a financial asset is categorized in one of three ways:
at amortized cost;
96
at fair value through other comprehensive income, distinguishing debt instruments and
equity instruments, or;
at fair value through profit or loss.
This categorization depends on both:
contractual cash flows of the instrument;
the Company’s business model of ownership of the instrument.
A financial asset is measured at amortized cost if it meets both of the following conditions and is
not designated as being at fair value through profit or loss:
it is held under a business model whose objective is to hold assets in order to collect con-
tractual cash flows;
its contractual terms give rise, on specified dates, to cash flows that are solely payment of
principal and interest on the outstanding principal amount.
To date, the Company doesn’t hold non-current financial assets.
Receivables are presented as current assets because they have a maturity of less than 12
months at the reporting date. All of these financial assets are measured at amortized cost.
To date, the Company does not hold financial assets at fair value through other comprehensive
income or profit or loss (other than cash).
Details of current financial assets are presented in Note 4.4 "Receivables and deferred ex-
penses"
5.5.9.2. Financial liabilities
Financial liabilities consist of bonds, bank loans, passive derivatives, repayable advances and
certain current liabilities. In accordance with IFRS 9, financial liabilities are assessed at amortized
cost or at fair value through profit or loss.
The convertible bond “OCA 2017” issued by the Company includes, on the one hand, a debt in-
strument and, on the other hand, an equity instrument. The financial debt component of converti-
ble bonds is measured at fair value. The fair value of the conversion option was calculated by de-
termining the difference between the issue value and the fair value of the debt component; and
was recognized as equity.
The convertible bond into shares with equity warrants “OCABSA 2019” issued by the Company
includes, on the one hand, a debt instrument and, on the other hand, a derivative instrument. The
financial debt component of the convertible bonds is measured at fair value. The conversion op-
tion is considered a passive derivative incorporated into the contract and recognized at fair value
through profit or loss. The fair value of the OCABSA conversion option was calculated using an
optional model.
Currently, all other financial liabilities are initially recognized at fair value net of transaction costs
incurred and subsequently measured at amortized cost using the effective interest rate method.
They are classified as current or non-current liabilities according to their maturity. The amount of
interest recognized as financial expenses is determined by applying the effective interest rate to
their carrying amount.
97
Current financial liabilities mainly include the less than one-year part of bonds and bank loans,
repayable advances as well as trade payables, tax and social security debts and the less than
one-year share of loans. Non-current financial liabilities include the portion at more than one year
of these liabilities.
The Company derecognizes a financial liability when its contractual obligations are extinguished
or cancelled or expire. The Company also derecognizes a financial liability when its terms are
changed and the cash flows of the modified liability are materially different, in which case a new
financial liability based on the amended terms is recognized at fair value.
Repayable advances
The Company benefits from a number of repayable advances or zero-interest loans.
A repayable advance is treated as a government grant if there is reasonable assurance that the
Company will meet the conditions for forgiveness of the loan. Otherwise, it is classified as a finan-
cial liability and measured at amortized cost in accordance with IFRS 9.
The benefit derived from a repayable advance obtained at a lower interest rate than the market
rate is treated as a government grant, corresponding to the difference between the amounts re-
ceived and the fair value of the loan according to the market interest rate then in force. The
amount resulting from the benefit recognized as a government grant included in the "Other reve-
nue" line of net income. The financial expense calculated at the market rate using the effective
interest rate method is presented in the financial result.
Gross financial debt
Gross financial indebtedness includes loans and debts from credit institutions, lease liabilities as
well as unmatured accrued interest, passive cash, and derivative instruments.
Composition of gross financial debt
Aelis Farma’s gross financial debt breaks down as follows:
Bank loans:
BPI bank loan: in December 2018, the Company took out a remunerated bank loan with
Bpifrance for €1,000,000 and a term of 8 years. An amount of €50,000 was withheld as a
cash pledge and was included in the calculation of the effective interest rate. The loan will
be repaid according to a schedule of 20 quarterly installments including the amortization
of the capital and the payment of interest. The first deadline was March 31, 2022, and the
last was December 31, 2026. In addition, during the deferred period of amortization of the
capital, interest will be paid quarterly in a timely due term. In 2020, due to the Covid-19
crisis, the deadlines of March and June 2022 have been postponed. The schedule has
been amended accordingly, with two additional quarterly deadlines, the last of which is
June 30, 2027.
State-guaranteed loans: in June 2020, the Company took out two State-Guaranteed
Loans (PGE), one with Bpifrance and another with Crédit Agricole. The purpose of this
financing is to strengthen cash flow following the Covid-19 crisis. Each loan is in the
amount of €550,000 and has a duration of 1 year. These two financings benefit from a
State Guarantee under the guarantee fund "FDG Etat Coronavirus" up to 90%. The loan
with Crédit Agricole, with an interest rate of 0.55%, will be repaid according to a schedule
of 48 monthly payments. The first maturity is set for August 22, 2022, and the last for July
22, 2026. The loan with Bpifrance, with an interest rate of 2.25%, will be repaid according
to a schedule of 16 quarterly installments. The first deadline is set for October 31, 2022,
and the last for July 31, 2026.
98
Convertible bonds:
2017 convertible bond “OCA 2017”: a bond issue was set up during the year ended 31
December 2017 for a total amount of €700,002 with the Nouvelle-Aquitaine Region. Each
convertible bond will be entitled, under the conversion conditions referred to in the Con-
vertible Bond Issuance Agreement, to one ordinary share of the Company. Convertible
bonds will not produce interest. The full repayment of convertible bonds on their due date,
no later than June 29, 2022, will not be accompanied by any non-conversion premium.
The contract contains various clauses involving the possibility of conversion or early re-
payment depending on scientific or financial events. This bond loan is in particular con-
vertible in the event of an initial public offering on a regulated market: as such, it was con-
verted after the closing date following the initial public offering of the Company.
OCA 2017
Name
OCA2017
Number of bonds
Exercise price
149
€4,698
Issue price
€700,002
Parity
1 share for 1 convertible bond
Interest rate
0 %
Subscription date
Repayment date
Maturity
2017-07-12
2022-06-29
5 years
Non-conversion premium
Fair value of debt component
Fair value of equity component
0 %
€547,092
€152,910
2019 convertible bond into shares with equity warrants “OCABSA 2019”: a bond issue
was set up during the year ended 31 December 2019 for a total amount of €1,500,023
with the Nouvelle-Aquitaine Region and Inserm Transfert Initiative. Each convertible bond
will be entitled, under the conversion conditions referred to in the Convertible Bond Issu-
ance Agreement, to one ordinary share of the Company, together with a Ratchet BSA
(equity warrant). Convertible bonds will earn interest at an annual rate of 1% as of the day
of subscription, September 25, 2019. The full repayment of convertible bonds on their due
date, no later than June 19, 2024, will not be accompanied by any non-conversion pre-
mium. The contract contains various clauses involving the possibility of conversion or
early repayment depending on scientific or financial events. This bond loan is in particular
convertible in the event of an initial public offering on a regulated market: as such, it was
converted after the closing date following the initial public offering of the Company.
OCABSA 2019
Name
OCABSA 2019
Number of bonds
Exercise price
Issue price
25,543
€58.73
€1,500,140
Parity
1 ABSA for 1 convertible bond
Interest rate
Subscription date
1 %
2019-08-26
99
Repayment date
2024-07-19
5 years
0 %
Maturity
Non-conversion premium
Fair value of debt component
Fair value of equity component
Fair value of BSA
€1,254,099
€261,114
€0
Repayable advances: the Company benefits from public funding from the Nouvelle Aqui-
taine Region and Bpifrance.
A repayable advance of €900,000 at a zero percent rate was awarded by the Nouvelle
Aquitaine Region as part of the creation as an innovative Company during the 2014 finan-
cial year. This repayable advance was due March 2019. An amendment signed in 2019
changed the repayment schedule, which now runs from 2019 to 2024. In 2020, due to the
Covid-19 crisis, the June 2020 repayment was postponed by one year. The schedule has
been amended accordingly, with an additional annual repayment on June 30, 2026.
The benefit constituted by the difference between the amount of the advance received
and that of the advance discounted at a market rate (4,06 %) is considered to be a gov-
ernment grant.
A repayable advance of €800,000 at a zero percent rate was awarded by Bpifrance as
part of its support for the Company's Research and Development program during the
2014 financial year. This debt is repayable according to a schedule of 20 quarterly install-
ments, the first maturity of which was set for March 31, 2020, and the last of which was
December 31, 2024. In 2020, due to the Covid-19 crisis, the repayments of March and
June 2020 were postponed. The schedule has been amended accordingly, with two addi-
tional quarterly repayments, the last of which is June 30, 2025.
The benefit constituted by the difference between the amount of the advance received and
that of the advance discounted at a market rate (4,06 %) is considered to be a government
grant.
A repayable advance of €600,000 at a zero percent rate was awarded in 2019 by
Bpifrance as part of its support for the Company's Research and Development program
("Deeptech"). This debt is repayable according to a schedule of 5 annuities, the first ma-
turity of which is set at June 30, 2024, and the last at June 30, 2028. As of June 27, 2019,
€420,000 have been paid. The balance of the advance, i.e., €179,000, has been paid on
December, 22 2021.
The benefit constituted by the difference between the amount of the advance received
and that of the advance discounted at a market rate (4,06 %) is considered to be a sub-
sidy.
An innovation grant of €500,000 in the form of a zero-rate repayable advance was
awarded in 2019 by the Nouvelle-Aquitaine Regional Council as part of the support for
the Company's Research and Development program. The first installment of €250,000
was collected on January 2, 2020, and the balance of €250,000 was paid on July 9, 2021.
The benefit constituted by the difference between the amount of the advance received
and that of the advance discounted at a market rate (4,06 %) is considered to be a sub-
sidy.
Lease liability, determined in accordance with IFRS 16.
100
Change in gross financial debt
During the 2020-2021 period, all of the Company's loans were denominated in euros and were at
a fixed interest rate.
GROSS FINANCIAL DEBT
In thousands of euros
12/31/21
12/31/20
Non-current bonds loans
Bank loans
1,403
1,858
-
1,991
2,050
21
Lease liabilities
Repayable advances
Passive derivatives
1,958
1,505
34
1,705
222
19
Accrued interests
Sub-total other non-current financial liabilities
Current bond loans
6,759
683
192
260
21
6,008
-
Bank loans
-
Repayable advances
Lease liabilities
240
25
Bank overdraft
-
63
Accrued interests
2
0
Sub-total other current financial liabilities
Gross financial debt
1,158
7,917
328
6,336
MATURITY OF LOANS TO CREDIT INSTITUTIONS AND LEASE LIABILITIES
In thousands of euros
12/31/21
12/31/20
Less than 1 year
Between 1 and 5 years
More than 5 years
Total
1,158
6,433
326
328
5,848
160
7,917
6,336
LEASE LIABILITIES
In thousands of euros
12/31/21
12/31/20
Less than 1 year
Between 1 and 5 years
More than 5 years
Total
21
-
25
21
-
-
21
46
101
FINANCIAL DEBTS EXCLUDING LEASE LIABILITIES
In thousands of euros
12/31/21
12/31/20
Less than 1 year
Between 1 and 5 years
More than 5 years
Total
1,137
6,433
326
303
5,827
160
7,896
6,290
RECONCILIATION OF CHANGES IN GROSS FINANCIAL DEBT AND CASH FLOW FROM FINANCING ACTIV-
ITIES THROUGH FINANCIAL DEBTS
In thousands of euros
12/31/21
12/31/20
Balance at the beginning of the period
Proceeds
6,336
429
(203)
(25)
(55)
146
152
-
4,912
1,413
(70)
(24)
(44)
1,275
137
Repayments
Repayment of lease liabilities
Gross financial interest paid
Cash flow from financing activities through financial debts
Cost of debt
Increase of lease liabilities
Changes in derivatives
-
1,283
-
48
Other
(36)
6,336
Balance at the end of the period
7,917
5.5.9.3. Net financial debt
The Company's net financial debt corresponds to gross debt less cash and cash equivalents.
NET FINANCIAL DEBT
In thousands of euros
12/31/21
12/31/20
Gross financial debt
Cash
7,917
6,336
(4,538)
1,798
(24,710)
(16,793)
Net financial debt
Fair value of financial assets and liabilities
Fair value is defined as the price that would be received for the sale of an asset or that would be
paid for the transfer of a liability in an orderly transaction between market participants at the
measurement date.
Fair value is based on market data and commonly used valuation models and can be confirmed
in the case of complex instruments by reference to prices supplied by independent financial insti-
tutions.
Fair value measurement techniques
IFRS 13 "Fair Value Measurement" establishes a hierarchy of the different valuation techniques
for financial instruments.
102
The categories are defined as follows:
level 1 input data: inputs directly based on quoted prices (unadjusted) in active markets
for identical assets or liabilities that the entity can access at the measurement date;
level 2 input data: inputs other than quoted prices included within Level 1 that are observ-
able for the asset or liability, either directly or indirectly;
level 3 input data: prices established using valuation techniques based on unobservable
data.
The fair value measurement of passive derivatives in connection with bond issues is carried out
in accordance with the methodology described in Note 3.3 "Critical Accounting Judgments and
Key Sources of Uncertainty in The Estimates".
CARRYING AMOUNT AND FAIR VALUES BY LEVEL OF FINANCIAL ASSETS AND LIABILITIES
12/31/2021
12/31/20
Fair value
through
other com-
prehensive
income
Financial
instru-
ments at
amor-
Fair
value
through
P&L
In euros
Fair
value
level
Carrying Fair
amount
Carrying
amount
value
tised cost
Other non-current financial
assets
Receivables and prepaid
expenses
Other current financial
assets
-
-
-
-
-
-
-
-
-
3,299
-
-
-
-
3,299
-
1,346
-
-
-
-
Cash and cash equivalents
Total financial assets
Banks loans non-current
Passive derivatives
Level 1
24,710
28,009
5,254
1,505
2,243
1,158
10,346
469
24,710
24,710
5,254
1,505
-
24,710
-
-
4,538
5,935
5,787
222
927
328
0
-
24,710
0
-
3,299
5,253
-
-
-
Level 3
1,505
-
Trade payables and related
items
-
-
-
-
-
-
-
2,243
1,159
-
Banks loans - current
Deferred revenue
Other debts
1,158
-
-
-
-
-
-
-
-
469
9,124
335
7,599
Total financial liabilities
20,975
7,917
1,505
0
103
ADDITIONAL INFORMATION FOR LEVEL 3 VALUATION (OCABSA 2019)
Valuation methods
12/31/21 12/31/20
Valuation used in the calculation for the underlying ordinary share
Price of the last transactions observed on capital
€58.73
€58.73
Other quantitative elements taken into account in the valuation of financial instruments (other inputs of the
black & Scholes model)
Estimated 5-year underlying asset volatility
Risk-free rate
45.63 %
-0.19 %
0 %
62.07 %
-0.16 %
0 %
Dividend rate
5.5.9.4. Financial Risk Management
Risk Management Framework
The purpose of the Company's management policy is to identify and analyze the risks the Com-
pany is facing, to define the limits within which the risks must lie and the controls to be imple-
mented to manage them.
Liquidity risk
Description of the risk
Liquidity risk is the risk of not being able to meet its repayment obligations related to financial lia-
bilities.
Risk Management
The Company's highly capital-intensive activity has led it to develop approaches based on the
identification and anticipation of financial needs. The management of these risks is based on:
a budget process subject to periodic updates, mainly oriented towards cash manage-
ment, shared internally between the various stakeholders of the Company, and regularly
supervised by the Governance of the Company (Board of Directors, Audit Committee);
the search for non-dilutive financing by the management team, from national partners
(Bpifrance, Conseil Régional Nouvelle Aquitaine, banking partners), European partners
(ICOD and ERDF programs), and foreign partners (funding obtained from NIDA, National
Institute on Drug Abuse, part of the American National Institute of Health, NIH);
the search for dilutive financing, mainly conducted by the Company's Chief Executive Of-
ficer, from specialized investors and funds that historically support the Company;
the search for industrial partnerships conducted by the management team and by the
Company's Chief Executive Officer, with pharmaceutical groups interested in the thera-
peutic area in which the Company operates.
When setting up major financing (fundraising, industrial partnerships), the funds made available
are placed with the Company's banking partners, in risk-free instruments.
Interest rate risk
Description of the risk
Exposure to interest rate risk is linked to the existence of variable-rate debt, the medium-term
cost of which may vary according to changes in interest rates.
104
Risk Management
The Company's debts are fixed-rate debts. Aelis Farma is not exposed to interest rate risk.
Currency risk
Description of the risk
Exposure to foreign exchange risk is related to the existence of expenses in a currency other
than the Euro (mainly in US dollars), the Company's functional and presentation currency for the
financial statements.
Risk Management
In 2020, the Company did not implement a policy to hedge foreign exchange risk using a hedging
instrument.
In 2021, the Company chose to set up auto-hedging in dollars following the receipt of the $30 mil-
lion for the license option agreed with Indivior PLC. Thus, these funds in dollars will be used to
finance the future costs of the research program carried out in this currency (studies related to
AEF0117 in the United States), constituting thereby a natural exchange rate hedge.
Credit risk
Description of the risk
Credit risk represents the risk that a client (or another counterparty to a financial asset) will not
honor its contractual obligations.
Risk Management
For the Company, this risk is considered low or even zero.
5.5.10. Other current and non-current liabilities
OTHER CURRENT AND NON-CURRENT LIABILITIES
In thousands of euros
12/31/21 12/31/20
Deferred revenue non-current
Subtotal non-current contrat liabilities
Trade payables and related accounts
Employee and social charges payables
Tax payables
6,339
6,339
2,243
344
-
-
927
254
50
125
Other
-
32
Deferred revenue - current
Subtotal other current liabilities
Total other liabilities
10,346
13,058
19,397
-
1,263
1,263
105
TRADE PAYABLES
In thousands of euros
12/31/21 12/31/20
Trade payables
2,243
927
Total trade payables
2,243
927
Trade payables have a maturity of less than one year at each closing.
The increase in trade payables is mainly related to research and development contracts in pro-
gress at the closing date, in particular for pre-clinical studies for AEF0117 and AEF0217 (ADME
studies, toxicity studies and pharmacological studies of safety, production of clinical batches),
and clinical studies (preparation of the phase 2b for AEF0117 and implementation of the phase 1
for AEF0217).
CONTRACT LIABILITIES
In thousands of euros
12/31/21 12/31/20
Deferred revenue non-current
Deferred revenue - current
6,339
10,346
16,685
0
0
0
Total other liabilities
Current and non-current deferred revenue consist of:
The share of Indivior PLC revenue corresponding to the performance obligation described
in Note 5.2 - Revenue. It will be recognized over time following costs during the execution
of the phase 2b of the AEF 0117 program, i.e., between the second half of 2021 and
2023.
The ICOD grant received in advance in 2021 for which expenses were incurred from the
first half of 2021 and will continue in 2022.
5.6. Notes to the Statement of Net Income
5.6.1. Segment information
In accordance with IFRS 8, segment information is prepared on the basis of internal management
data used for business performance analysis and resource allocation.
An operating segment is a separate component of the entity that is engaged in the provision of
separate products and services and is exposed to risks and profitability different from the risks
and profitability of other operating sectors.
The Company operates in only one operating segment corresponding to the research and devel-
opment of treatments for neurological diseases. The assets, liabilities and operating loss pre-
sented in the financial statements relate to the activities of the Company located in France.
5.6.2. Revenue
In June 2021, the Company entered into a license option contract forAEF0117 with the leading
addiction treatment group, Indivior PLC, under which Aelis Farma granted an option for an exclu-
sive license on the EP12194704.8 and EP18305177.0 patent families and associated know-how.
This contract allows Indivior PLC to operate worldwide a pharmaceutical product including the
106
compound AEF0117 or certain other pregnenolone derivatives covered by these patent families,
in cannabis use disorders, addictions and other compulsive behaviors.
Aelis’ remuneration is as follows:
at the signing of the contract, the Company received a lump sum payment of USD 30 mil-
lion;
if the option is exercised by Indivior PLC, the Company will receive a second lump sum
payment of USD 100 million;
conditional payments based on technical, regulatory and then commercial milestones, up
to USD 340 million;
royalties, between 12 to 20%, on sales of the drug containing AEF0117.
The accounting principles applied to the revenue from these contracts are derived from IFRS 15.
The detailed analysis of the contract allowed the identification of two performance obligations
within this contract:
1: The communication of data relating to the completion of the phase 2b clinical study of
AEF0117 and a toxicity study, during the period of the option, for which Aelis Farma must
make its best efforts, and whose additional data will allow Indivior PLC to exercise the op-
tion. The revenue was allocated to this performance obligation by projecting the future
costs relating to the realization of the phase 2b study, including the direct costs of sub-
contracting, the direct costs of the teams assigned to carry out these studies and a share
of the indirect costs of structure, as well as a margin.
2: The license option granted to Indivior PLC with a right of return, implying the provision,
on the date of signature of the contract, of the information relating to the Research and
Development program developed since the beginning of the project. Under the residual
method, the income related to this second component is measured as the difference be-
tween the total amount received of USD 30 million and the income associated with the 1st
performance obligation. It is recognized in revenue at the signing of the contract.
Thus, the option income of 30 million USD, or €24,616,000, is recognized according to the follow-
ing schedule:
At signature of the contract: €7,921,000
And, for the balance, i.e., €16,695,000, as and when the costs related to the completion
of the phase 2b study and the toxicity study are recognized, i.e., from the second half of
2021 for the preparatory phases, and until the results expected to be obtained in the first
half of 2024. As such, an additional €1,154,000 was recognized in 2021, i.e., a total reve-
nue of €9,075,000.
REVENUE
In thousands of euros
12/31/21 12/31/20
Revenue
9,075
-
Total revenue
9,075
-
107
5.6.3. Other revenue
The item "Other revenue" mainly includes the impact of government grants linked or not to as-
sets, including the Research Tax Credit.
Due to the nature of its research activities, Aelis Farma receives a number of grants from the
Government, local authorities or other public organizations. The treatment of these resources is
governed by IAS 20 "Accounting for government grants and disclosure of government assis-
tance".
Government grants
Government grants are not accounted for until there is reasonable assurance that the Company
will comply with the conditions attached to the grants and that the grants will be received.
Government grants are recognized in net income on a systematic basis over the periods in which
the Company recognizes as expenses the related costs that the grants are intended to offset.
Specifically, government grants related to investments in non-current assets are initially recog-
nized as deferred income and then progressively over the useful life of the non-current assets fi-
nanced under the item "Other revenue".
Government grants covering operational expenses are directly recognized as "Other revenue"
during the period of recognition of the expenses they cover.
The grants obtained by the Company are as follows:
A grant from Bpifrance Financement for "Deeptech" financing of €600,000 was awarded
in 2019 and €420,000 was received in the 2019 financial year and the balance, €180,000
in the 2021 financial year. This grant is recorded in the income statement on the basis of
the progress of the work financed, i.e., €440,000 for the 2019 financial year, €158,000 for
the 2020 financial year and the balance, €300.00 in the 2021 financial year.
A grant from the European Union under the ERDF-ESF Aquitaine 2014-2020 Operational
Programme of €500,000, was awarded in 2019 and €250,000 was received in the 2020
financial year. This grant is fully recorded in the income statement on the basis of the pro-
gress of the work financed over the past financial years. The payment of the balance is
expected in the 2022 financial year.
A European grant under the ERDF-ESF Aquitaine 2014-2020 Operational Programme of
€400,000, was awarded in 2020 and €200,000 of this was received in the 2021 financial
year. This grant is recorded in the income statement on the basis of the progress of the
work financed, i.e., €109,400 for the 2020 financial year and €193,000 for the 2021 finan-
cial year. The funded program is expected to end in 2022.
A European grant under the Horizon 2020 operational program, for a maximum amount of
€5,989,800, was allocated in 2021 to the ICOD program aimed at financing the pre-clini-
cal and clinical development program of AEF0217 in Down syndrome for the 2021 to
2025 financial years. This financing is granted to a consortium of which Aelis Farma is
one of the main contributors: the financing granted directly to the Company, of
€3,353,400, represents 55.99% of the total ICOD program budget. As such, the company
received an advance of €1,463,500 in the 2021 financial year. This grant is recorded in
the income statement on the basis of the progress of the work financed, i.e., for the 2021
financial year. The balance is recognized as short-term prepaid income on the liabilities
side of the balance sheet.
108
The treatment of repayable advances is described in Note 4.9.2 “Financial liabilities”.
Research tax credit
Aelis Farma benefits from the research tax credit (CIR) under French tax legislation, granted by
the State in order to promote scientific and technical research.
The amount of the CIR:
may be deducted from income tax due in respect of the year in which it was granted, as
well as for the following three financial years; or
in certain circumstances, the excess may also be reimbursed to the Company.
The Company considers the CIR to be a government grant within the meaning of IAS 20, as the
Company may benefit from it independently of its income tax payments. The Company recog-
nizes this receivable in other current receivables, given the expected repayment period. Re-
search tax credits are recorded under "Other revenue".
OTHER REVENUE
In thousands of euros
12/31/21 12/31/20
Research tax credit
1,089
518
80
692
385
60
Government grants
IAS20 (government grants)
Other
-
-
Other revenue from ordinary activities
1,687
1,137
5.6.4. Research and Development Costs
As noted above in Note 3.2 "Basis of Preparation", the Company has opted for a presentation of
its expenses by function.
The item "Research and Development expenses" includes expenses directly attributable to the
Research and Development activities carried out by Aelis Farma. This item recovers the following
costs:
cost of raw materials used by the Company's laboratory;
other purchases and external expenses corresponding mainly to subcontracting costs
dedicated to Research and Development programs and purchases of raw materials and
consumables necessary for testing; depreciation and amortization related to capitalized
equipment and development costs;
personnel costs corresponding to the salaries and related expenses of the teams dedi-
cated to research;
intellectual property corresponding to patent maintenance fees and filing costs and royal-
ties on license revenues paid to patent holders. As of December 31, 2021, license fees
correspond in particular to a payment of €1.7 million under the contract by which INSERM
and the University of Bordeaux license to the Company the patent for AEF0117. This pay-
ment is related to the collection of the fixed amount of 30 million USD of the license op-
tion agreement with Indivior PLC described in Note 5.2.
109
RESEARCH AND DEVELOPMENT COSTS
In thousands of euros
12/31/21 12/31/20
Cost of raw materials
(79)
-
Other purchases and external expenses
Employee costs
(3,064)
(1,808)
(1,919)
(6,870)
(1,741)
(1,351)
(296)
Intellectual property
Research and Development costs
(3,388)
5.6.5. General and administrative costs
As noted above in Note 3.2 "Basis of Preparation", the Company has opted for a presentation of
its expenses by function.
This item collects all administrative and overhead expenses, including salaries and related ex-
penses of dedicated teams as well as all other current operating expenses not allocated to Re-
search and Development expenses.
GENERAL AND ADMINISTRATIVE COSTS
In thousands of euros
12/31/21 12/31/20
Employee costs
(779)
(562)
(305)
(353)
(658)
Other purchases and external expenses
General and administrative costs
(1,341)
5.6.6. Employee Benefits
Employee benefits are considerations of all forms granted by the Company for the services ren-
dered by the members of its personnel or for the termination of their employment.
These benefits, assessed in accordance with IAS 19 "Employee benefits", fall into four catego-
ries:
short-term benefits (paid leave, sick leave, bonuses, etc.);
post-employment benefits (retirement benefits, social security pension and supplemen-
tary pensions);
other long-term benefits (work medals, seniority-related paid leave), and;
termination benefits.
Short-term benefits are staff benefits that are expected to be paid in full within 12 months of the
reporting date of the financial year in which the staff members rendered the corresponding ser-
vices. They are recorded as current debts and recorded as an expense when the service is ren-
dered by the employee.
Personnel expenses, by nature, presented below, include personnel expenses relating to re-
search and development, as well as general and administrative expenses.
110
EMPLOYEE BENEFITS
In thousands of euros
12/31/21 12/31/20
Salaries
1,543
578
1,164
305
Social security expenses
Share-based payments
Post-employment benefits expenses
Total employee benefits
443
172
25
25
2,588
1,665
COMPANY WORKFORCE
Company Workforce
12/31/21 12/31/20
Executives
19
4
8
2
Employees
Apprentices
1
1
Total workforce at year end
24
11
5.6.7. Depreciation and impairment
DEPRECIATION AND IMPAIRMENT
In thousands of euros
12/31/21 12/31/20
Amortization of intangible assets
Rights-of-use depreciation
4
21
10
35
-
0
21
8
Depreciation of tangible assets
Subtotal depreciation of property, plant and equipment and intangible assets
Other provisions
30
-
Subtotal net provisions
-
-
Total allocations and reversals on depreciation, depreciation and amortiza-
tion and provisions
35
30
5.6.8. Non-current operating income and expenses
In order to facilitate the understanding of the income statement and the performance of the Com-
pany, transactions which, due to their unusual or particularly significant nature, are likely to distort
the understanding of the Company's economic performance, are assigned to the operating in-
come line entitled "non-current operating income and expenses".
These are income and expenses that are not usual in their frequency, nature or amount, such as
income or expenses representative of significant and non-recurring disputes, penalties, impair-
ments and/or disposals of fixed assets.
111
NON-CURRENT OPERATING INCOME AND EXPENSES
In thousands of euros
12/31/21 12/31/20
Other operating income
-
-
-
183
(113)
70
Other operating expenses
Other operating income and expenses
Non-current operating income and expenses recorded in 2020 correspond to compensation re-
ceived following a breakdown in commercial talks and associated expenses (advisory fees).
5.6.9. Financial result
The financial result consists of the cost of financial debt and other financial income and ex-
penses. The cost of net financial debt is composed of interest expense on borrowing and lease
liabilities as well as income on cash and cash equivalents.
COST OF NET FINANCIAL DEBT
In thousands of euros
12/31/21 12/31/20
Interest income
1
1
Interest expenses on loans
Interest expenses on leases liabilities
Total cost of net financial debt
(137)
(2)
(135)
(3)
(137)
(137)
TOTAL FINANCIAL INCOME AND EXPENSES
In thousands of euros
12/31/21 12/31/20
Foreign exchange gains (losses)
723
(1,380)
(0)
(17)
(48)
(1)
Changes in fair value of financial instruments
Interest costs on retirement benefits
Total other financial income and expenses
(657)
(66)
5.6.10. Income taxes
Income tax is equal to the total amount of current tax and deferred tax included in the determina-
tion of the result for the period. It is recognized in profit or loss unless it relates to a business
combination or to items that are recognized directly in equity or other comprehensive income.
5.6.10.1.Current income taxes
Tax payable (current tax) is the amount of income tax payable (receivable) in respect of taxable
profit (tax loss) in a financial year and should be recognized as a liability to the extent that it is not
paid. If the amount already paid for the preceding and current period exceeds the amount due for
those periods, the excess shall be recognized as an asset.
Tax liabilities (assets) due for the preceding and current period are measured at the amount ex-
pected to be paid or recovered from tax administrations using tax rates and regulations adopted
or quasi-adopted on the balance date in each country where the Company operates.
112
According to the Company's analysis, the French value-added contribution (“CVAE”) meets the
definition of an income tax as defined by IAS 12 "Income Taxes" and is therefore presented on
the income taxes line in the statement of net income.
DETAILS OF TAX RECOGNIZED IN NET INCOME
In thousands of euros
12/31/21 12/31/20
Income tax
(229)
(956)
-
Deferred income tax
Total income tax expense
956
956
(1,185)
The standard corporate income tax rate applied to reported net income is 26.5% in 2021 (2020:
28%).
RECONCILIATION BETWEEN THE EFFECTIVE TAX RATE AND THE APPLICABLE TAX RATE TAX PROOF
In thousands of euros
12/31/21 12/31/20
Profit (loss) before tax
1,759
26.5%
(466)
(117)
1
(3,042)
28.0 %
852
Income tax rate applicable to the Company
Theoretical tax expense
Income and expenses related to share-based payments
Other temporary differences
(48)
5
Research tax credit
289
193
Contribution Economique Territoriale (CET-"local economic contribution")
Impact resulting from uncapitalized or impaired tax loss carryforwards
Uncapitalized deferred tax assets
(38)
(464)
(360)
(20)
(25)
Tax rate difference
Income tax expense
Net income (loss)
(29)
(1,185)
574
956
(2,085)
5.6.10.2.Deferred taxes
Deferred tax results from temporary differences between the carrying amounts of assets and lia-
bilities and their tax bases.
Deferred tax assets and liabilities are measured at the expected tax rates in the year in which the
asset will be realized, or the liabilities extinguished and that have been adopted or quasi-adopted
at the balance date. In the event of a change in the tax rate, deferred taxes are adjusted to the
new prevailing rate and the adjustment is expensed unless it relates to an item recognized in eq-
uity or other comprehensive income, including actuarial differences.
Deferred taxes are reviewed at each closing to take into account possible changes in tax legisla-
tion and the prospects for recovery of deductible temporary differences. A deferred tax asset is
recognized only to the extent that it is likely that the Company will have deferred tax liabilities of
the same maturity or future taxable profits against which that asset can be offset over a foreseea-
ble horizon. The determination of the amount of deferred taxes that can be recognized requires
management to make estimates both on the period of consumption of deficit carryforwards, and
on the level of future taxable profits, with regard to tax management strategies.
113
Deferred tax assets and liabilities are not discounted.
Deferred tax assets and liabilities are offset if the Company has a legally enforceable right to off-
set assets and liabilities of tax due and if they are related to income taxes levied by the same tax
authority and the Company intends to settle the net amount of its tax assets and liabilities due.
Deferred tax assets and liabilities
The following table presents the major deferred tax assets and liabilities recognized by the Com-
pany and their evolution during the current and previous reporting periods.
DEFERRED TAX ASSETS AND LIABILITIES
Other
In thousands of euros
12/31/19
Net income comprehen-
sive income
12/31/20
Leases
10
83
3
-
2
-
13
110
Retirement benefit provisions
Financial instruments
Acquisition fees
25
(206)
60
67
(139)
70
10
-
Tax losses carried forward
Deferred tax basis
Presented as:
13,591
13,537
3,481
3,586
-
17,072
17,124
2
Deferred tax basis
4,196
(4,196)
-
598
357
956
1
(1)
-
4,795
(3,839)
956
Deferred tax assets impairment
Net deferred tax assets
DEFERRED TAX LIABILITIES
Other
In thousands of euros
12/31/20
Net income comprehen-
sive income
12/31/21
Leases
13
110
(3)
-
(35)
(2)
-
10
100
Retirement benefit provisions
Financial instruments
Acquisition fees
25
(139)
70
1,363
-
1,222
70
Tax losses carried forward
Deferred tax basis
Presented as:
17,072
17,124
(1,819)
(434)
-
15,253
16,655
(37)
Deferred tax basis
4,795
(3,839)
956
(390)1
(566)2
(956)
9
(9)
-
4,414
(4,414)
-
Deferred tax assets impairment
Net deferred tax assets
(1) Including € (256,000) of tax rate difference
(2) Including € (489,000) relating to deferred taxes activated in 2020 but not used in 2021
As the conditions of IAS 12 are met by the Company with regard to the taxation of its profits, car-
ried out in France only, an offset is made between deferred tax assets and liabilities.
Tax assets: at the end of the 2021 financial year, the Company had unused tax losses of
€15,323,000 (at the end of 2020: €17,142,000) which it can charge to future profits within the an-
nual deductibility limits.
114
A deferred tax asset was recognized for €956,000 in 2020 and no deferred tax assets were rec-
ognized in 2021.
The tax planning prepared by the Company over three years shows a tax profit as at 31 Decem-
ber 2021 that justifies this recognition. This deferred tax asset was used and therefore taken up
as at 31 December 2021.
As at 31 December 2021, no deferred tax assets have been recognized as it is not considered
likely that future taxable profits will be available.
5.6.10.3.Uncertain tax positions related to income tax
In accordance with IFRIC 23 interpretation "Uncertainties over Tax Income Treatments", a tax as-
set or liability is recognized in the event of uncertainty about the treatment of income tax. As soon
as it is likely that a tax administration will not accept an uncertain tax treatment, the Company
recognizes a tax liability without taking into account the probability of non-detection by the tax au-
thorities. Conversely, if the Company considers it likely that a tax authority will reimburse a tax
paid, a tax claim is established. Assets and liabilities related to these uncertainties are estimated
on a case-by-case basis based on the most likely amount.
The Company has not identified any significant uncertain tax position with respect to income tax.
5.7. Note to the cash-flow statement
The statement of cash flow is prepared in accordance with IAS 7 "Statement of cash flows". It
thus distinguishes cash flows from operating activities from those of investing and financing activ-
ities.
Cash flows from operating activities are presented using the indirect method. Under this method,
they are determined by adjusting net income to take into account the effects of changes during
the period in inventories and operating receivables and liabilities (WCR) as well as non-cash
items, mainly depreciation, provisions and deferred taxes.
Cash flows from investing activities are mainly cash outflows from the acquisition of fixed assets
and cash inflows from the disposal of fixed assets.
Cash flows from financing activities mainly correspond to debt issuances and cash repayments of
borrowed amounts.
Cash flows from income taxes are presented separately and classified as cash operating flows,
unless they can be specifically linked to financing and investing activities.
115
OPERATING CASH FLOWS
12/31/21
12 months 12 months
12/31/20
Amounts in thousands of euros
Profit (loss) for the period
574
(2,086)
Elimination of depreciation and amortization of intangible and tangible as-
sets
36
30
Expenses related to share-based payments
Expenses related to defined benefit plans
443
24
172
25
Neutralization of the impact of the restatement of government grants on net
income
(16)
19
Reclassification of interest income and expenses
Income tax expense
740
103
1,185
(956)
Net cash flow from operating activities before changes in working cap-
ital requirements, financial interest and income taxes
(2,985)
(2,693)
Variation of working capital requirement
Research tax credit of the period
16,383
(1,089)
692
116
(692)
791
Cashed in research tax credit (N-1)
Cash flows from operating activities
18,970
(2,478)
The net cash consumption generated by the activity was €18,970,000 for the year ended 31 De-
cember 2021, against a net cash burn of €2,478,000 for the year ended 31 December 2020.
The generation of a net cash surplus over the 2021 financial year is mainly due to the receipt of
$30 million from Indivior PLC for the license option agreement signed.
This net cash consumption is mainly due to Research and Development expenses and fees,
which amounted to €6,870,000 in 2021 and €3,388,000 in 2020, which are partially offset by Re-
search Tax Credits receipts from the previous year. Thus, the Company obtained the reimburse-
ment of the 2020 and 2019 CIRs respectively in July 2021 and August 2020 for €692,000 and
€791,000.
INVESTING CASH FLOWS
12/31/21
12 months 12 months
12/31/20
Amounts in thousands of euros
Acquisitions of intangible and tangible assets
Financial interest received on investments
Cash flows from investing activities
(213)
1
(35)
1
(212)
(34)
The main cash flows from investing activities in 2021 relate to the acquisition of property, plant
and equipment for the creation of an in-house research laboratory; as in 2020, this item also in-
cludes the payment of patent royalties in accordance with the license agreements from which the
Company benefits.
116
FINANCING CASH FLOWS
12/31/21
12 months 12 months
12/31/20
Amounts in thousands of euros
Capital increase
-
-
-
-
Costs relating to the capital increase
Issuance of bond loans net of fees
Subscription of warrants
-
-
35
2
Issuance of bank loans
-
63
Receipt of advances and loans for innovation, net of costs
Repayment of advances and loans for innovation
Repayment of debt on lease obligations
Repayment of bank overdraft
447
(140)
(25)
(63)
(74)
180
1 350
(70)
(24)
-
Gross financial interest paid
(44)
1,277
Cash flows from financing activities
Net cash flows from financing activities for the year ended 31 December 2021 and 31 December
2020 amounted to €180,000 and €1,277,000 respectively.
These cash flows related to financing are mainly generated by transactions related to the financ-
ing of innovation and operating activities:
repayable advances awarded by Bpifrance (Deeptech program whose final payment of
€180,000 was collected in 2021), by the Nouvelle Aquitaine Region (innovation aid the
initial payment of €250,000 was received in 2020 and the balance of €250,000 was re-
ceived in 2021);
two State-guaranteed loans, taken out in equal amounts from Bpifrance and Crédit
Agricole, for a total of €1,100,000, paid in July 2020 as part of the support measures for
companies in the context of the Covid-19 pandemic.
As at 31 December 2021, cash and cash equivalent amounted to €24,710,000, an increase of
€20,172,000 compared to the 2020 financial year.
5.8. Events after the reporting period
After December 31, 2021, the Company listed on Euronext’s compartment B regulated market on
February 18, 2022.
Transformation into a public limited Company with a Board of Directors
The General Meeting of January 11, 2022 approved the transformation of the Company into a
public limited Company with a Board of Directors, the said transformation taking effect on the
same day.
Modification of the nominal unit value of the Company’s shares
The General Meeting of January 11, 2022 decided to divide the par value of the shares by 24. It
was thus reduced from €0.096 to €0.004, thus increasing the number of Company shares from
399,698 to 9,592,752.
117
IPO and capital increase
On February 15, 2022, the Company announced the success of its IPO on compartment B of the
regulated market of Euronext Paris, carried out by way of an open price offer (the "OPO") and a
global placement (the “Global Placement”, together with the OPO, the “Offer”).
The Offer price was set at €14.02 per new ordinary share. 1,822,794 ordinary shares were allo-
cated under the Offer, representing an amount of €25.55 million. The capital increase of an initial
amount of €25 million, i.e. 1,783,167 new shares, has been increased to approximately €25.3 mil-
lion after partial exercise of the over-allotment option by issuing 20,691 additional new shares.
This last capital increase was carried out on March 17, 2022, by decision of the Chief Executive
Officer acting within the framework of the sub-delegation, granted by the Board of Directors by its
decision dated February 15, 2022, within the framework of the delegation made to it by the Com-
bined General Meeting of January 11, 2022.
The start of listing on the Euronext market took place on February 18, 2022, after finalization of
the capital increase and implementation of settlement-delivery on February 17, 2022.
This IPO, also involved:
the conversion into ordinary shares of ABSA B resulting in the cancellation of the BSA
Ratchet 2017 and 2019;
the issue, on the date of completion of the initial public offering, of new ordinary shares,
because of: the conversion of the Convertible Bonds previously issued (OC2017 and
OC2019), for respective amounts of €700,002 and €1,500,022.93 in ordinary shares of the
Company. It was therefore considered that this conversion had no impact on the maturity
of the CBs at the end of the financial year: the 2017 CBs are presented with a maturity of
less than one year and the 2019 CBs are presented with a maturity.of one to five years;
the exercise of 600 BSA2019, 2,682 BSA2020, 20 BSPCE2017-1 and 300 BSPCEOCT2020
;
allocation to the issue premium of the costs related to this fundraising, for a total amount
estimated at approximately €2.8 million. In this respect, as at December 31, 2021, the
costs incurred in the 2021 financial year in direct connection with the capital increase dur-
ing the IPO, i.e., €421,293.42, were recognized as prepaid expenses. and will be de-
ducted from the issue premium for the 2022 financial year.
Situation in Ukraine
The conflict initiated in February 2022 between Russia and Ukraine has no direct significant im-
pact on the Company's operational activity, as it has no service provider or ongoing operation in
these two countries.
5.9. Off-balance-sheet commitments
5.9.1. Commitments received
Commitments received directly by the Company: none.
5.9.2. Commitments given
The Company has signed several exclusive patent license agreements with public institutions.
These contracts include clauses for the payment of milestones based on stages of development,
and royalties based on future sales. They charge Aelis Farma with the responsibility for and fi-
nancing of the costs of filing, maintaining and defending these patents.
118
5.10. Related Party Transactions
According to IAS 24, Related Party Disclosure, a related party is a person or entity that is related
to the reporting entity.
These may include:
a person or Company that exercises control over the Company;
an associated Company of the group;
a joint venture;
a key member of the Company’s management team (or a member of his/her family).
A transaction with a related party involves a transfer of goods, services or obligations between
the Company and that related party.
EXECUTIVE COMPENSATION
Remuneration of Pier Vincenzo Piazza
12/31/21 12/31/20
Euros
Short-term employee benefits
Post-employment benefits
Share-based payments *
Termination benefits
501,137
346,643
-
3,314
-
-
10,534
-
Total remuneration of the Chairman of the SAS
504,451
357,423
(*) In accordance with IFRS 2
OTHER TRANSACTIONS WITH RELATED PARTIES
Other transactions with related parties
Amounts in thousands of euros
Note 12/31/21 12/31/20
Consulting service Thomas Conseil SPRL
a.
b.
20
0
15
35
50
Consulting service Gerselconsult ApS
Total services purchased from related parties
20
a. The Board of Directors, at its meeting of April 26, 2019, authorized the Company to enter into a consulting con-
tract with Thomas Conseil SPRL. Mr. François Thomas, President of Thomas Conseil SPRL, is a member of the
Company's Board of Directors.
The purpose of the contract is to provide assistance to Aelis Farma in the search for financing, and assistance in
the negotiation of financing. This contract was concluded for the year 2019, without tacit renewal.
A new similar contract was formed between the parties on 13 January 2020 for the period running until 31 De-
cember 2020, then renewed in 2021, with a revision of the amount of fees due for the year.
b. The Board of Directors of the Company entered into another consulting contract with the Danish Company
Gerselconsult Aps on 18 February 2020. Mr. Anders Gersel, Chairman of the Board of Directors of Aelis Farma, is
also a director of Gerselconsult Aps.
The purpose of the contract is to provide assistance to the Company in clinical studies, regulatory procedures,
search for industrial partners. This contract had no effect in 2021.
119
5.11. Auditors’ fee
AUDITORS’ FEES
Euros
12/31/21 12/31/20
Financial statements certification
Other services
26,002,
7,025,
33,027
12,576
7,115
Total fees
19,691
The fees invoiced during the 2021 financial year and relating to the capital increase transactions
carried out during the IPO in February 2022 are not presented in this table, being attached to the
2022 financial year.
As of December 31, 2021, these fees amounted to €150,000 and were recognized as prepaid ex-
penses in order to be charged later to the issue premium.
5.12. Transition to IFRS
5.12.1. Transition approach
The Company has prepared financial statements under IFRS for the first time for the financial
years ended December 31, 2020, 2019 and 2018 as part of the planned initial offering of shares
on the French regulated market. They had been established specifically for the purpose of the
Registration Document subject to AMF approval (Autorité des Marchés Financiers).
The financial statements for the year to December 31, 2020, were the first that the Company had
prepared in accordance with IFRS standards in effect as of December 31, 2020, and IFRS 1
"First Adoption of International Financial Reporting Standards" has been applied to all periods
presented from the transition date to January 1, 2018.
The financial statements under IFRS established for the financial year ended December 31, 2021
are therefore the first established as part of the annual closing of a Company listed on a regu-
lated market.
5.12.2. Mandatory exceptions and optional exemptions applied
Since IFRS 1 was applied to the first set of accounts established for the period from January 1,
2018 to December 31, 2020, the principles adopted are detailed below.
IFRS 1 allows early adopters exemptions from the retrospective application of certain require-
ments under IFRS.
The Company has applied the mandatory exceptions regarding:
the classification and valuation of financial instruments;
depreciation of financial assets;
public loans.
The other mandatory exceptions are not applicable to the Company. The optional exemptions ap-
plied by the Company relate to IFRS 16 "Leases" and IFRS2.
120
IFRS 16: Leases
The Company has adopted IFRS 16 as of January 1, 2018.
The Company has evaluated all existing contracts as of January 1, 2018 to determine whether a
contract constitutes a lease within the meaning of IFRS 16.
An entity that applies IFRS for the first time and is a lessee is permitted to apply the following ap-
proach to all of its leases on the transition date:
the lease liabilities were assessed at the present value of the remaining lease payments,
discounted on the basis of the lessee’s incremental borrowing rate at the transition date
of January 1, 2018;
right-of-use assets were measured at an amount equal to the lease liability, adjusted by
the amount of any prepaid or accrued lease payments relating to that lease recognized in
the statement of financial position immediately before 1 January 2018.
IFRS 2: Share-Based Payments
The Company did not apply IFRS 2 to a plan settled prior to the transition date.
121
5.12.3. Reconciliation of the Statement of Financial Position
STATEMENT OF FINANCIAL POSITION AS AT 31 DECEMBER 2020
FR
IAS 32-
IAS
19
IAS IFRS
IFRS 2
IAS 20
IFRS
Gaap IFRS 9
12
16
Retire-
ment
benefit ment
De-
In thousands of
euros
Financial Share-
12/31/20 instru- based
Govern- ferred
in-
Leases 12/31/20
ments
payment provi-
sions
grants
come
tax
Intangible assets
60
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
39
-
60
48
Property, plant and
equipment
Other non-current financial
assets
9
-
-
-
-
Deferred tax assets
-
956
-
956
1,064
1,396
-
Total non-current assets
70
956
39
-
Receivables and prepaid
expenses
1,396
-
-
Current financial assets
Cash and cash equivalents
Total current assets
Total assets
-
-
4,538
5,935
6,004
-
-
-
4,538
5,935
6,999
-
956
39
Shareholders’ equity
(1,841)
-
(12)
-
-
-
(110)
110
-
304
-
956
(7)
-
(709)
110
Employee commitments
-
-
-
Non-current financial debts
(1)
6,279
(209)
(304)
21
5,787
Provisions other
non-current debts
-
-
-
-
-
-
0
-
-
-
-
-
-
-
-
-
-
-
-
-
-
222
-
Passive derivatives
222
-
-
-
Deferred tax liabilities
-
-
13
-
-
-
-
-
Total non-current
liabilities
6,279
303
-
110
(304)
-
21
25
-
6,119
328
-
Current financial liabilities
Current provisions
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Trade payables and related
items
927
304
-
-
-
-
927
304
-
Fiscal and social debts
Deferred revenue
-
-
-
-
-
-
Other current debts
32
-
-
-
-
32
Total current liabilities
Total equity and liabilities
1,565
6,003
-
25
39
1,590
6,999
1
956
(1) In accordance with IAS 1, the holdback amount of €50,000 on the Bpifrance loan of €1 million has been offset
with the corresponding liability, and is translated into the column "FR Gaap" for simplification.
122
STATEMENT OF FINANCIAL POSITION AS AT 31 DECEMBER 2021
FR
Gaap
IAS 32-
IFRS 9
IAS
19
IAS IFRS
IFRS 2
IAS 20
IFRS
12
16
Retire-
ment
benefit ment
provi- grants
sions
De-
In thousands of
euros
Share-
based
pay-
Financial
12/31/21 instru-
ments
Govern- ferred
in-
come
tax
Leases 12/31/21
ment
Intangible assets
90
179
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
90
196
Property, plant and
equipment
Other non-current financial
assets
-
-
-
-
-
-
-
-
-
Deferred tax assets
Total non-current assets
Inventory
-
-
-
-
-
-
-
269
17
-
-
-
-
18
-
287
-
-
-
-
17
Receivables and prepaid
expenses
3,299
-
-
-
-
-
-
3,299
-
Current financial assets
Cash and cash equivalents
Total current assets
Total assets
-
-
-
-
-
24,710
28,027
28,296
2,074
-
-
-
-
-
-
24,710
28,027
28,313
899
-
-
-
-
-
-
-
-
-
18
(4)
-
Shareholders’ equity
Employee commitments
(1,391)
-
(101)
320
-
-
101
-
101
Non-current financial debts
(1)
Provisions other
non current debts
5,582
6,339
-
(97)
-
-
(231)
-
5,253
6,339
1,505
-
-
-
-
-
-
Passive derivatives
1,505
-
-
-
-
Deferred tax liabilities
-
-
-
-
-
-
Total non-current
liabilities
11,921
1,244
-
1,408
0
101
(231)
-
13,198
1,158
-
Current financial liabilities
Current provisions
(16,8)
-
-
-
-
-
-
-
-
-
(90)
21
-
-
-
-
-
Trade payables and related
items
2,243
469
10,346
-
-
-
-
2,243
469
Fiscal and social debts
Deferred revenue
-
-
-
-
-
-
-
-
10,346
-
Other current debts
-
-
(17)
-
-
(90)
-
-
Total current liabilities
Total equity and liabilities
14,301
28,296
-
21
18
14,215
28,313
-,
(1) In accordance with IAS 1, the holdback amount of €50,000 on the Bpifrance loan of €1 million has been offset
with the corresponding liability, and is translated into the column "FR Gaap" for simplification.
123
5.12.4. Reconciliation of statement of net income
RECONCILIATION OF STATEMENT OF NET INCOME AS AT 31 DECEMBER 2020
FR
Gaap
IAS 32-
IFRS 9
IAS
19
IAS IFRS
IFRS 2
IAS 20
IFRS
12
16
Retire-
ment Govern- ferred
benefit ment
De-
In thousands of
euros
Financial
12/31/20 instru-
ments
Share-
based
in-
come
tax
Leases 12/31/20
payment provi- grants
sions
Revenue
-
-
-
-
-
-
-
-
-
-
-
-
-
Other operating income
1,077
60
1,137
Revenue from ordinary
activities
Research and Development
costs
General and administrative
costs
Recurring operating profit
(loss)
1,077
(3,249)
(606)
(2,778)
70
-
-
-
-
-
-
-
60
-
-
-
-
-
-
-
-
1,137
(3,388)
(658)
(2,910)
70
(121)
(51)
(172)
-
(18)
(6)
(25)
-
-
5
5
-
60
-
Other operating income and
expenses
Operating profit (loss)
Financial income (loss)
Profit (loss) before tax
Income tax expense
Net income (loss)
(2,708)
(72)
-
(172)
-
(25)
(1)
60
(79)
(19)
-
-
-
5
(3)
3
(2,840)
(202)
(48)
(48)
-
(2,780)
-
(172)
-
(25)
-
-
(3,042)
956
956
956
-
(2,780)
(48)
(172)
(25)
(19)
3
(2,086)
RECONCILIATION OF STATEMENT OF NET INCOME AS AT 31 DECEMBER 2021
FR
Gaap
IAS 32-
IFRS 9
IAS
19
IAS IFRS
IFRS 2
IAS 20
IFRS
12
16
Retire-
ment Govern- ferred
benefit ment
De-
In thousands of
euros
Financial
12/31/21 instru-
ments
Share-
based
in-
come
tax
Leases 12/31/21
payment provi- grants
sions
Revenue
9,075
1,607
-
-
-
-
-
-
-
-
-
-
-
9,075
1,687
Other operating income
80
Revenue from ordinary
activities
Research and Development
costs
General and administrative
costs
Recurring operating profit
(loss)
10,683
(6,486)
(1,264)
2,934
-
-
-
-
-
-
-
-
80
-
-
-
-
-
-
-
-
10,762
(6,870)
(1,340)
2,552
-
(370)
(73)
(443)
-
(15)
(9)
(24)
-
-
5
5
-
80
-
Other operating income and
expenses
Operating profit (loss)
Financial income (loss)
Profit (loss) before tax
Income tax expense
Net income (loss)
2,934
652
-
(443)
-
(24)
-
80
(64)
16
-
-
5
(2)
3
2,552
(794)
1,759
(1,185)
574
(1,379)
(1,379)
-
-
3,586
(229)
3,357
(443)
-
(25)
-
-
(956)
(956)
-
(1,379)
(443)
(25)
16
3
124
5.12.5. Description of the main impacts of the IFRS transition
IAS 32 IFRS 9: Financial Instruments
The application of these standards has led to the recognition of the following impacts:
for the OCA 2017 issued by the Company: the fair value of the OCA's conversion option,
which was calculated by determining the difference between the issue value and the fair
value of the debt component, is recognized as equity.
for OCABSA 2019 issued by the Company: the conversion option is considered a deriva-
tive incorporated into the contract and recognized at fair value through profit or loss.
for Tranche 2 and Tranche 3 BSAs: fair value has been recognized in equity.
IFRS 2: Share-Based Payments
The Company has restated all outstanding plans not yet settled at the transition date in accord-
ance with IFRS 2 and applied the optional exemption for the single plan settled on the transition
date. The accounting rules and policies applied are described in Note 4.7 Share-based pay-
ments. Restatement of share-based payments results in an additional operating expense in re-
turn for equity. The cumulative expense on the plans in progress at the transition date resulted in
an intra-equity reclassification with no net impact on presentation.
IAS 19: Employee Benefits
The application of the standard leads to the recognition of the commitment under the defined
benefit plan as a liability. Actuarial gains and losses resulting from changes to calculation as-
sumptions and adjustments related to experience are recognized in other comprehensive income.
The net expense for the financial year, corresponding to the current service cost, plus whereby
appropriate the past service cost, is recognized in operating expenses.
Commitments were not recognized under the previous standard.
IAS 20: Government grants
The application of the standard leads to the recognition of the benefit derived from a repayable
advance obtained at an interest rate lower than that of the market as a public subsidy, corre-
sponding to the difference between the amounts received and the fair value of the loan according
to the market interest rate then in force. The amount resulting from the benefit recognized as a
government grant is presented in the "Other revenue" line of net income. The financial expense
calculated at the market rate using the effective interest rate method is presented in the financial
result.
IAS 12: Deferred Taxes
The amounts presented on these lines correspond to the tax effect of restatements between the
previous benchmark and IFRS standards included in net income and equity as well as the recog-
nition of deferred tax assets.
IFRS 16: Leases
The application of the standard leading to the recognition of a right of use and a lease liability on
the balance sheet also leads to the recognition of a depreciation expense and financial interests
instead of a lease expense as an operating expense over the term of the contract. The rights of
use and lease liabilities recognized at opening are presented respectively in Tangible fixed assets
and Gross financial debt.
125
The difference between the previously recorded lease expense and the depreciation and amorti-
zation expense is the impact on operating income.
The difference between the total expense (depreciation and amortization and financial expenses)
for IFRS leases and the previously recognized lease expense is the impact on net income.
While operating lease payments were presented in cash flows from operating activities, these
rent payments are now divided into cash outflows relating to the interest expense on the lease
liabilities and the repayment of that debt. The Company presents the repayment of the principal
of the lease obligation and the interest paid in the cash flows related to financing activities.
126
Section 6 - Individual financial statements prepared in
accordance with French Gaap as of December 31, 2021
ASSETS
Amortization
and
depreciation
12/31/21
Gross
12/31/21 12/31/20
In euros
Net
Net
Intangible assets
Concessions, patents and similar rights
Total Intangible assets
90,671
503
90,167
60,181
90,671
503
90,167
60,181
Property plant and equipment
Plant machinery, equip. and tooling
Other tangible fixed assets
Advances and down-payments
Total property plant and equipment
Financial fixed assets
125,296
77,065
11,355
213,716
3,948
31,005
-
121,348
46,060
11,355
178,763
-
9,381
-
34,953
9,381
Other financial assets
50,000,
50,000
-
50,000,
50,000,
318,930
50,000
50,000
119,562
Total financial fixed assets
TOTAL NON-CURRENT ASSETS
Inventory and work in progress
Raw materials, supplies
-
354,387
35,457
17,450
-
17,450
-
Advances and down-payments made on orders
Receivables
56,552
-
56,552
906
Other receivables
1,635,520
24,710,551
1,606,695
28,026,769
1,000
-
1,635,520
1,339,093
Cash and cash equivalents
Prepaid expenses
-
24,710,551 4,538,141
1,606,695 56,526
28,026,769 5,934,666
1,000,
-
TOTAL CURRENT ASSETS
Translation adjustment on assets
TOTAL ASSETS
-
-
-
28,382,156
35,457
28,346,699 6,054,228
127
LIABILITIES
In euros
12/31/21
12/31/20
Share capital
3,997
35,051
3,995
934,958
-
Additional paid-in capital
Retained earnings (accumulated losses)
Net profit (loss) for the period
Investment grants
(1,848,688)
3,356,001
1,142,791
2,689,153
1,039,147
1,000
(2,783,646)
-
TOTAL SHAREHOLDERS’ EQUITY
Conditional advances
(1,844,693)
1,000,000
Provisions for liabilities
Financial Liabilities
Convertible bond loans
Bank borrowings
2,234,217
2,102,296
1,500,067
5,836,580
2,219,025
2,162,808
1,250,067
5,631,900
Other loans and borrowings
Total financial liabilities
Operating liabilities
Trade payables and related accounts
Tax and social security liabilities
Total operating liabilities
Other liabilities
2,243,093
468,685
927,506
303,724
1,231,230
31,500
2,711,778
526,983
Deferred income
15,541,000
24,616,341
1,058
-
TOTAL LIABILITIES
6,894,630
4,291
Translation adjustment on liabilities
TOTAL LIABILITIES
28,346,699
6,054,228
128
INCOME STATEMENT
In euros
12/31/21
12/31/20
Products sold (services and works)
Net Revenue
9,075,395
9,075,395
4,000
-
-
Operatinggrants
-
Reversals of provisions and impairment losses, expense transfers
Otherincome
34,374
70,340
49
604,271
9,718,039
96,908
Total operating income
70,339
2,653
-
Purchases of materials and other supplies
Change in inventory
(17,450)
3,799,525
63,323
Other external purchases and expenses
Taxes and similar duties
2,402,856
18,015
1,163,595
304,820
Wages and salaries
1,518,698
571,085
Personnel social security costs
Depreciation and Amortization
- Depreciation and amortization of fixed assets
- Allocations to provisions
13,615
1,000
8,456
-
Other expenses
1,771,176
7,817,880
1,900,158
1,336
26,266
3,926,661
(3,856,272)
1,459
Total operating expenses
OPERATING PROFIT
Other interest income and similar income
Positive translation adjustment
Total financial income
118,569
119,905
72,523
-
1,225
2,685
Interest expenses and similar expenses
Negative translation adjustment
Total financial expenses
56,301
22,546
78,846
(76,162)
(3,932,434)
72,523
47,382
1,947,540
FINANCIAL INCOME (EXPENSE)
PRE-TAX PROFIT (LOSS) ON ORDINARY ACTIVITIES
Exceptional income
- From revenue transactions
- From capital transactions
Exceptional expenses
3,565
184,758
384,837
514,110
- From revenue transactions
- From capital transactions
EXCEPTIONAL PROFIT (LOSS)
Income tax
-
112,463
47
-
517,675
(890,786)
10,355,619
6,999,617
3,356,001
457,085
(691,703)
642,668
3,426,314
(2,783,646)
Total Income
Total Expenses
NET PROFIT (LOSS) FOR THE PERIOD
129
6.1. Significant events during the period
The balance sheet for the period totaled €28,346,699.
The income statement presented in the form of a list shows total income of €10,355,619 and total
expenses of €6,999,617, resulting in a net profit of €3,356,001.
The period under review begins on 01/01/2021 and ends on 12/31/2021.
It runs for 12 months.
In June 2021, the Company entered into an industrial partnership in the form of an exclusive li-
cense option agreement of the industrial property for AEF0117 in the field of cannabis-related dis-
orders, with Indivior PLC. This agreement provides:
initially, an exclusive license option granted to Indivior PLC, until the end of the phase 2b
study of AEF0117. At the end of this study, Indivior PLC may or may not exercise the op-
tion. During this period, Aelis Farma undertakes to make its best efforts to carry out the
phase 2b study and to communicate the results to Indivior PLC. This option was remuner-
ated by a payment at the signing of the contract of an amount of USD 30 million, non-re-
fundable and without retrocession to Indivior PLC.
if Indivior PLC exercises this option at the end of the phase 2b study, it will benefit from
an exclusive license allowing it to complete the development phase of the project, then to
produce and market the drug. Aelis Farma would then license in particular the two pa-
tents protecting AEF0117, research results, knowledge, and know-how acquired since the
start of the project. Indivior PLC will then pay an amount of USD 100 million on the sign-
ing of the license agreement then various sums upon the achievement of technical, regu-
latory and commercial milestones, up to USD 340 million as well as royalties on sales
ranging between 12 and 20%.
At the same time, the Company paid the royalties due to the owners of the patents covering
AEF0117, following the receipt of license income relating to the license option signed with Indivior
PLC, for an amount of €1,683,000.
This agreement enables the Company to generate significant revenue during the period. The ac-
counting treatment of this contract is specified below in the Section Accounting rules and meth-
ods.
6.2. Events after the closing date
After December 31, 2021, the Company was listed on the regulated market of Euronext compart-
ment B, on February 18, 2022.
Transformation into a limited company with Board of Directors
The General Meeting of January 11, 2022, approved the transformation of the Company into a
limited Company with a Board of Directors, taking effect on the same day.
Change in the nominal unit value of the Company's shares
The General Meeting of January 11, 2022, decided to split the value of the shares by 24. It was
thus reduced from €0.096 to €0.004, thereby increasing the number of Company shares from
399,698 to 9,592,752.
130
IPO and capital increase
On February 15, 2022, the Company announced the success of its initial public offering on com-
partment B of the regulated market of Euronext Paris, carried out by way of an open price offer
(the "OPO") and a global placement (the “Global Placement”, together with the OPO, the “Offer”).
The Offer price was set at €14.02 per new ordinary share. 1,822,794 ordinary shares were allo-
cated under the Offer, representing an amount of €25,55 million. The capital increase of an initial
amount of €25 million, i.e., 1,783,167 new shares, has been increased to approximately €25.3
million after partial exercise of the over-allotment option by issuing 20,691 additional new shares.
This last capital increase was carried out on March 17, 2022, by decision of the Chief Executive
Officer acting within the framework of the sub-delegation, granted by the Board of Directors by its
decision dated February 15, 2022, within the framework of the delegation made to it by the Com-
bined General Meeting of January 11, 2022.
The start of trading on the Euronext market took place on February 18, 2022, after completion of
the capital increase and implementation of the settlement-delivery on February 17, 2022.
The legal and accounting impacts of this IPO, apart from the capital increase described above,
are as follows:
conversion into ordinary shares of ABSA B resulting in the cancellation of the BSA
Ratchet 2017 and 2019.
conversion, on the date of introduction:
of convertible Bonds previously issued (CBs2017 and CBs2019), for respective amounts
of 700,002 and 1,500,022.93 in ordinary shares of the Company. It was therefore con-
sidered that this conversion had no impact on the maturity of the CBs at the end of the
financial year: CBs2017 are presented with a maturity of less than one year and CBs2019
are presented with a maturity of one to five years;
of 600 BSA2019, 2682 BSA2020, 20 BSPCE2017-1 and 300 BSPCEOCT2020
.
allocation to the issue premium of the costs related to this fundraising, for a total amount
estimated at approximately €2.8 million. As such, as of December 31, 2021, the costs in-
curred in the 2021 financial year directly related to the capital increase during the IPO,
i.e., 421,293.42, were recognized as prepaid expenses and will be deducted from the
issue premium for the 2022 financial year.
Situation in Ukraine
The conflict initiated in February 2022 between Russia and Ukraine has no direct significant im-
pact on the Company's operational activity, as it has no service provider or ongoing operation in
these two countries.
6.3. Accounting rules and principles
The annual financial statements for the period have been drawn up in accordance with all the
regulations which have amended the General Chart of Accounts adopted by ANC regulation
n°2014-03 of June 5, 2014 and presented in accordance with the general rules applicable in this
area and in line with the principle of prudence.
The accounting conventions have been applied in compliance with the principle of prudence and
according to the following basic principles:
131
going concern;
consistency of accounting methods;
independence of financial years.
The basic method used for the valuation of items recorded in the accounts is the historical cost
method.
No change in the methods of valuation and in the methods of presentation has been made.
The main methods used are:
6.3.1. Intangible assets
Initially, separately acquired intangible assets are measured at cost.
The Company's intangible fixed assets mainly include royalties when technical milestones are
reached, paid in accordance with the license agreements that bind Aelis Farma to the owners of
the patents. These amounts will be amortized as soon as they generate economic benefits.
Start-up costs and research costs are directly recognized as expenses in the year in which they
are incurred.
Development expenditure is recognized as an intangible asset if the Company is able to demon-
strate verification of all of the following criteria:
the technical feasibility necessary to complete the intangible asset with a view to its com-
missioning or sale;
its intention to complete the intangible asset and use or sell it;
its ability to use or sell the intangible asset;
how the intangible asset will generate probable future economic benefits;
the availability of appropriate technical, financial and other resources to complete the de-
velopment and use or sell the intangible asset, and;
the ability to measure reliably the expenditure attributable to the intangible asset during its
development.
Failing this, this expenditure constitutes expenses. Currently, the Company does not recognize
any development costs as intangible assets.
Indeed, due to the risks and uncertainties related to regulatory authorizations and the research
and development process, the above criteria are not met, in particular the criterion concerning
technical feasibility. Thus, expenditure incurred before these criteria are met are accounted for as
expenses.
6.3.2. Tangible fixed assets
Tangible fixed assets are valued at their acquisition cost (purchase price and incidental costs, ex-
cluding fixed asset acquisition costs) or at their production cost.
Depreciation is calculated according to the linear or decreasing method according to the normal
duration of use of the goods.
132
Non-depreciable parts of fixed assets are recorded at their gross value consisting of the purchase
cost excluding incidental costs.
When the inventory value is lower than the net book value, depreciation accounts for the differ-
ence.
6.3.3. Financial fixed assets
Financial fixed assets are valued at their entry cost. They are made up solely of sums retained as
cash collateral for the bank loan granted by Bpifrance.
6.3.4. Receivables and debts
Receivables and debts have been valued at their nominal value.
Receivables are, where applicable, depreciated by means of a provision to take into account the
collection difficulties to which they are likely to give rise.
6.3.5. Prepaid expenses and deferred income
Prepaid expenses are determined in accordance with the principles of separation of financial
years. They correspond in particular to research and development contracts with successive exe-
cution. When the effective date of the contract does not coincide with that of the financial year,
the amount paid, corresponding to the fraction of the services which will only be performed during
a subsequent financial year, is recorded in prepaid expenses.
Deferred income corresponds to the accounting treatment of the Indivior PLC contract as de-
scribed below in the note relating to revenue. As of December 31, 2021, it includes the share of
Indivior PLC revenue corresponding to the future performance obligation, recognized over time
by costs during the execution of the phase 2b study of AEF0117 program. As of December 31,
2021, the portion estimated at more than one year is €6,338,000.
6.3.6. Inventory
On the date of entry into the Company's assets, inventories and work in progress are recorded at
their acquisition cost. Inventories are valued using the first-in, first-out method. Depreciation is
recognized where applicable.
6.3.7. Foreign currency transactions (debts and receivables in
foreign currencies)
Receivables and debts in foreign currencies are converted and accounted for in national currency
based on the last exchange rate.
When the application of the conversion rate on the closing date of the accounts has the effect of
modifying the amounts in national currency previously accounted for, the conversion differences
are recorded in the transitional accounts "translation differences".
Asset translation differences corresponding to unrealized losses are subject to a "provision for
foreign exchange loss" with the exception of differences related to supplier debts in USD included
in the self-hedging operations described in the following paragraph.
133
Unrealized gains related to exchange adjustments do not affect financial income.
6.3.8. Cash available
The cash available at the bank or in cash has been valued at its nominal value.
Liquid assets in foreign currencies are converted and accounted for in national currency based on
the last exchange rate.
When the application of the conversion rate on the closing date of the accounts has the effect of
modifying the amounts in national currency previously accounted for, the translation differences
are recorded in the income statement as exchange losses or gains.
In the specific case of transactions in USD, the Company has chosen to operate a self-hedging
approach by keeping cash in foreign currencies on its balance sheet (received from the Indivior
contract), in order to cover the costs of research and development in North America provided for
in its budget, services which will be invoiced by the subcontractors or clinical centers in this cur-
rency. Thus, in accordance with regulation no. 2015-05 of July 2, 2015 relating to forward finan-
cial instruments and hedging transactions, the revaluation at the closing rate of the cash account
in USD had the following effects:
for the part of the cash balance intended to cover future research and development oper-
ations in foreign currencies, as established based on the Company's budget, the recogni-
tion in “other debts” of the share of the variation thus determined; this amount will be re-
ported in the income statement when the research and development operations covered
by this, are settled;
for the balance in USD that does not hedge future transactions, an exchange rate varia-
tion was recognized in the income statement.
6.3.9. Capital increase costs
The capital increase costs are deducted from the issue premiums (preferential method).
No capital increase costs were charged to issue premiums for the financial year ended December
31, 2021.
6.3.10. Repayable advances and financial debts
The Company benefits from public funding from the Nouvelle-Aquitaine Region and Bpifrance:
a repayable advance of €900,000 at a zero rate was allocated by the Nouvelle-Aquitaine
Region as part of the creation of an innovative Company during the 2014 financial year.
This repayable advance is classified as financial debt and was due in March 2019. An
amendment signed in 2019 modified the repayment schedule, which now runs from 2019
to 2024. Due to the Covid-19 crisis, the June 2020 repayment which had initially been
suspended in 2020 was postponed again by one year to 2021. The schedule has been
modified accordingly, it includes an additional annual deadline scheduled for June 30,
2026.
a refundable advance of €800,000 at a zero rate was granted by Bpifrance as part of the
support for the Company's research and development program during the 2014 financial
year. This advance is classified as financial debt. It is repayable in 20 quarterly
134
installments, the first installment of which was set for March 31, 2020. In 2020, due to the
Covid-19 crisis, the March and June 2020 installments were postponed. The schedule
has been modified accordingly, it includes two additional quarterly deadlines, the last
deadline of which is scheduled for June 30, 2025.
a refundable advance of €600,000 at zero rate was granted in 2019 by Bpifrance as part
of support for the Company's research and development program (“Deeptech”). The mini-
mum amount reimbursable even in the event of technical failure, of an amount of
€150,000, has been recognized in miscellaneous financial debts. The balance of
€450,000 was recognized as conditional advances (other equity). This debt is repayable
according to a schedule of 5 annual installments, the first due date of which is set for
June 30, 2024, and the last for June 30, 2028. The balance of this advance, of €179,000,
was collected on December 22, 2021.
innovation support of €500,000 in the form of a zero-rate repayable advance was
awarded in 2019 by the Regional Council of Nouvelle-Aquitaine as part of support for the
Company's research and development program. The first installment of €250,000 was
collected on January 2, 2020, and the balance of €250,000 was paid on July 9, 2021.
This financing, recognized in various financial debts, comes in addition to the ERDF fi-
nancing allocated in 2019 described below.
in December 2018, the Company contracted an interest-bearing bank loan from Bpifrance
for an amount of €1,000,000 and a duration of 8 years. An amount of €50,000 was re-
tained as a cash pledge and is recognized as an asset on the balance sheet. The loan is
repaid according to a schedule of 20 quarterly installments including the amortization of
the capital and the payment of interest. The first installment was set for March 31, 2022,
and the last for December 31, 2026. During the deferred capital amortization period, inter-
est is paid quarterly in arrears. In 2020, due to the Covid-19 crisis, the March and June
2022 deadlines were ultimately postponed: the schedule was modified accordingly and
includes two additional quarterly deadlines, the last of which is scheduled for June 30,
2027.
in June 2020, the Company contracted two State Guaranteed Loans (PGE), one with
Bpifrance and one with Crédit Agricole. The purpose of this financing is to strengthen
cash flow to deal with the consequences of the Covid-19 crisis. Each loan is for an
amount of €550,000. These two financings benefit from a State Guarantee under the
"FDG State Coronavirus" guarantee fund up to 90%. The loan with Crédit Agricole, with
an interest rate of 0.55% will be repaid according to a schedule of 48 monthly payments.
The first maturity is set for August 22, 2022, and the last for July 22, 2026. The loan with
Bpifrance, with an interest rate of 2.25%, will be repaid according to a schedule of 16
quarterly installments. The first deadline is set for October 31, 2022, and the last for July
31, 2026.
6.3.11. Grants
a Bpifrance grant for "Deeptech" financing of €600,000 was awarded in 2019, with an ini-
tial payment of €420,000 in the 2019 financial year and the payment of the balance of
€179,000 in the 2021 financial year. This grant is reported in the income statement on the
basis of the progress of the works financed, i.e., €440,000 for the 2019 financial year, and
€158,000 for the 2020 financial year and €300 for the 2021 financial year.
a European grant under the 2014-2020 ERDF-ESF Aquitaine operational program, of
€500,000 was awarded in 2019 and €250,000 was received during the 2020 financial
135
year. This grant was fully recorded in the profit and loss account based on the progress of
work financed in previous years. The payment of the balance is expected in the 2022 fi-
nancial year.
a European grant under the 2014-2020 FEDER-ESF Aquitaine operational program of
€400,000 was allocated in 2020, of which €200,000 was received during the 2021 finan-
cial year. This grant is recorded in the income statement based on the progress of the fi-
nanced works, i.e., €109,400 for the 2020 financial year and €193,000 for the 2021 finan-
cial year. The financed program is expected to end in 2022.
a European grant under the Horizon 2020 operational program, for a maximum amount of
€5,989,800, was awarded in 2021 to the ICOD program aimed at financing the pre-clinical
and clinical development program of AEF0217 in the Down syndrome during the 2021 to
2025 financial years. This financing is granted to a consortium of which Aelis Farma is
one of the main contributors: the financing granted directly to the Company, for a total
amount of €3,353,400, represents 55.99% of the total budget of the ICOD program. As
such, the Company received an advance of €1,463,500 for the 2021 financial year. This
grant is recorded in the income statement on the basis of the progress of the works fi-
nanced, i.e., €320,700 for the 2021 financial year.
6.3.12. Convertible bonds
a bond issue was set up during the financial year ended December 31, 2017, for a total
amount of €700,002 with the Nouvelle-Aquitaine Region.
each convertible bond (CB) potentially gives the right, according to the conversion condi-
tions set out in the CB Issuance Agreement, to one ordinary share of the Company, with
an exercise value of €43.98. The CBs do not bear interest. The full amortization of the
CBs on their maturity date, no later than June 29, 2022, is not accompanied by any non-
conversion premium.
the contract includes various clauses involving the possibility of conversion or early re-
demption depending on scientific or financial events. This loan is in particular convertible
in the event of an initial public offering on a regulated market: in this respect, it was con-
verted after the closing following the initial public offering of the Company.
a bond loan was set up during the financial year ended December 31, 2019, for a total
amount of €1,500,023 with the Nouvelle Aquitaine Region and Inserm Transfert Initiative.
each CB gives the right, according to the conversion conditions set out in the CB Issu-
ance Agreement, to one ordinary share of the Company, with an exercise value of
€58.73, with a BSA Ratchet. The CBs bear interest at the annual rate of 1% from the day
of their subscription, i.e., September 25, 2019. The full amortization of the CBs on their
maturity date, no later than June 19, 2024, will not be subject to any non-conversion bo-
nus.
the contract includes various clauses involving the possibility of conversion or early re-
demption depending on scientific or financial events. This loan is in particular convertible
in the event of an initial public offering on a regulated market: in this respect, it was con-
verted after the closing following the initial public offering of the Company.
It is specified that the Company's loan agreements do not include any covenant-type clause
6.3.13. Revenue
In June 2021, the Company entered into a license option contract for AEF0117 with the leading
addiction treatment group, Indivior PLC, under which Aelis Farma granted an option for an
136
exclusive license on the EP12194704.8 and EP18305177.0 patent families and associated know-
how. This contract allows Indivior PLC to operate worldwide a pharmaceutical product including
the compound AEF0117 or certain other pregnenolone derivatives covered by these patent fami-
lies, in cannabis use disorders, addictions and other compulsive behaviors.
Aelis’ remuneration is as follows:
at the signing of the contract, the Company received a lump sum payment of USD 30 mil-
lion;
if the option is exercised by Indivior PLC, the Company will receive a second lump sum
payment of USD 100 million;
conditional payments based on technical, regulatory and then commercial milestones, up
to USD 340 million;
royalties, between 12 to 20%, on sales of the drug containing AEF0117.
The accounting principles applied to the revenue from these contracts are derived from IFRS 15.
The detailed analysis of the contract allowed the identification of two parts within this contract:
1) the communication of data relating to the completion of the phase 2b clinical study of
AEF0117 and a toxicity study, during the period of the option, for which Aelis Farma must
make its best efforts, and the additional data which will enable Indivior PLC to exercise
the option. The income has been allocated to this part by projecting the future costs relat-
ing to the performance of these studies, including the direct costs of subcontracting, the
direct costs of the teams assigned to the performance of these studies and a share of the
indirect structural costs, as well as a margin;
2) the results of previous studies as available on the date of signature of the contract: the
licence granted to Indivior PLC with right of return, implies the provision, on the date of
signature of the contract, of information relating to the Research and Development pro-
gram drawn up from the start of the project. Revenue related to this part is measured as
the difference between the total amount received of 30 million USD and the revenue as-
sociated with part 1. It is recognized as revenue at the signing of the contract.
Thus, the option revenue of 30 million USD, i.e., €24,616,000, is recognized according to the fol-
lowing schedule:
upon signature of the contract: €7,921,000;
and, for the balance, i.e., €16,695,000, as the costs relating to the completion of the
phase 2b study and of the toxicity study are accounted, i.e., from the second half of 2021
for the preparatory phases, and until the results expected in the first half of 2024. As
such, an additional €1,154,000 was recognized in 2021, i.e., total revenue of €9,075,000.
6.3.14. Purchases
Incidental purchase costs paid to third parties have not been incorporated into the purchase ac-
counts but have been accounted for in the various expense accounts corresponding to their na-
ture.
6.3.15. Executive compensation
The compensation of the Company's manager for the 2021 financial year amounted to: €501,137.
137
The manager also benefits from an indemnity equal to 6 months of gross compensation (based
on the annual compensation which includes fixed, variable and, if applicable, exceptional com-
pensation) in the event of termination of his duties as Chairman/ Chief Executive Officer resulting
from a decision of the Board of Directors.
6.3.16. Research and development expenses
In accordance with the practices in force in the biotechnology sector and in view of the difficulties
in assessing the probabilities of technical success of the research carried out by the Company,
research and development costs are recorded as expenses for the financial year and have not
been capitalized.
6.3.17. Income tax
The Company's activity makes it eligible for the tax mechanism of the research tax credit. As
such, the costs eligible under this mechanism, and the funding obtained under R&D are identified
according to the principles specific to this mechanism, allowing the recognition of income to be
received from the Treasury, after allocation, and where applicable, on income tax.
The tax rate applicable to the Company is the rate in force in France, i.e., 26.5%.
6.3.18. Retirement commitments
They correspond to end-of-career indemnities for staff, paid to employees when they retire, the
calculation of which is determined in accordance with the collective agreement for the pharma-
ceutical industry. These commitments are not provisioned in the corporate accounts and are pre-
sented as off-balance sheet commitments. The corresponding expense is recognized in the fiscal
year in which the employee actually leaves.
As of December 31, 2021, the actuarial assumptions used are as follows:
discount rate (IBOXX Corporates AA): 0.98%
salary increase: 2%
turnover: low
INSEE mortality table 2019
retirement age: 65-67 years of age
Retirement commitments are calculated in accordance with ANC recommendation 2013-02
(method 2: rights are recognized over the period of accumulation of seniority at the end of the ca-
reer). The commitments thus amount to €101,000, taking into account the impact of the change in
regulations of -€33,500.
The value of these commitments was €110,000 as at December 31, 2020.
138
6.3.19. Earnings per share (diluted basis)
EFFECT OF DILUTION ON EARNINGS PER SHARE
In euros
12/31/21
Net income (1)
3,371,193
399,500
109,409
508,909
6.62
Weighted average number of shared issued
Potentially dilutive shares
Weighted average number of diluted shares
Diluted earnings per share (euros/share)
(1) Net income adjusted for accrued interest on convertible bonds
6.3.20. Transactions with related parties
A related party transaction involves a transfer of goods, services or obligations between the Com-
pany and that of a related party.
TRANSACTIONS WITH RELATED PARTIES
Transactions with related parties (In thousand euros)
Note
12/31/21
12/31/20
Consulting service Thomas Conseil SPRL
Consulting service Gerselconsult ApS
a.
b.
20
-
15
35
50
Total purchases of services from related parties
20
a. The Board of Directors, during its meeting of April 26, 2019, authorized the Company to enter into a consulting
contract with Thomas Conseil SPRL. Mr. François Thomas, Chairman of Thomas Conseil SPRL, is a member of
the Company's Board of Directors. The purpose of the contract is to provide assistance to Aelis Farma in the
search for financing, and assistance in the negotiation of financing. This contract was concluded for the year
2019, without tacit renewal.
A new similar contract was formed between the parties on 13 January 2020 for the period running until 31 De-
cember 2020, then renewed in 2021, with a revision of the amount of fees due for the year.
b. The Board of Directors of the Company entered into another consulting contract with the Danish company
Gerselconsult Aps dated February 18, 2020. Mr. Anders Gersel, Chairman of the Board of Directors of Aelis
Farma, is also an executive of Gerselconsult Aps.
The purpose of the contract is to provide assistance to the Company in terms of clinical studies, regulatory proce-
dures and the search for industrial partners. This contract had no impact in 2021.
6.3.21. Company workforce
The average workforce for the 2021 financial year was 14 employees, compared to 10 for 2020.
COMPANY'S WORKFORCE AT THE END OF THE YEAR
Category of workforce
12/31/21
12/31/20
Executives
19
4
7
1
1
9
Employees
Apprentices
1
Workforce at end of period
24
139
6.4. Notes to the balance sheet
6.4.1. Fixed assets
6.4.1.1. Intangible assets
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN GROSS VALUES IN 2021
In euros
12/31/20
Acquisitions
Disposals
12/31/21
Concessions, patents and software
60,671
30,000
-
90,671
Total intangible assets
60,671
30,000
-
90,671
OTHER INTANGIBLE ASSETS: DECOMPOSITION AND CHANGES IN DEPRECIATION AND AMORTIZATION
IN 2021
Depreciation,
amortization
In euros
12/31/20
Reversals
12/31/21
and
impairment
Concessions, patents and software
489
14
-
503
Total intangible assets
489
14
-
503
6.4.1.2. Property plant and equipment
PROPERTY, PLANT AND EQUIPMENT: DECOMPOSITION AND CHANGE IN 2021 GROSS VALUES
In euros
12/31/20
Acquisitions
Disposals
12/31/21
Plant machinery, equipment and tooling
Plant, sundry fixtures and fittings
-
125,296
2,517
-
-
125,296
3,910
1,394
Office and computer equipment and
furniture
36,721
43,816
(7,382)
73,155
Advances and down-payments
-
11,355
-
11,355
Total property plant and equipment
38,115
182,984
(7,382)
213,716
PROPERTY, PLANT AND EQUIPMENT: DECOMPOSITION AND CHANGE IN DEPRECIATION 2021
Depreciation,
amortization
In euros
12/31/20
Reversals
12/31/21
and
impairment
Plant machinery, equipment and tooling
Plant, sundry fixtures and fittings
Other tangible assets
-
(3,498)
(1,275)
(8,378)
(13,601)
-
(3,498)
(1,303)
(29)
-
(28,705)
(28,734)
7,382
7,382
(29,702)
(34,953)
Total property plant and equipment
140
6.4.1.3. Financial fixed assets
FINANCIAL FIXED ASSETS: DECOMPOSITION AND CHANGE IN 2021 GROSS VALUES
In euros
12/31/20 Acquisitions
Disposals
12/31/21
50,000
-
-
50,000
Loans and other financial assets
Total financial fixed assets
50,000
-
-
50,000
6.4.2. Receivables and payables
DETAILS OF RECEIVABLES
More than 1
year
In euros
12/31/21
Up to 1 year
Other financial fixed assets
Amounts due from staff
Income tax
50,000
8
-
50,000
8
-
890,786
367,581
364
890,786
367,581
364
-
Value added tax
-
Other taxes, duties and similar payments
Other
-
352,414
24,368
1,606,695
3,292,216
352,414
24,368
1,606,695
3,242,216
-
Sundry debtors
-
Prepaid expenses
Total receivables
-
50,000
DETAILS OF PAYABLES
More
Up to 1
year
1 to 5
years
In euros
12/31/21
than 5
years
-
Convertible bond loans
2,234,217
171
700,002
171
1,534,215
Bank loans and borrowings 1-year max. at outset
Bank loans and borrowings >1 year at outset
Other loans and borrowings
-
-
2,102,124
1,500,000
2,243,093
78,464
193,229
200,000
2,243,093
78,464
265,640
124,581
67
1,808,895
100,000
1,300,000
-
Trade payables and related accounts
Amounts due to staff
-
-
-
-
Amounts due to social security, other social bodies
Other taxes and duties
265,640
124,581
67
-
-
-
-
Amounts due to Group companies and shareholders
Other payables
-
-
526,983
526,983
-
-
Deferred income
15,541,000 9,203,490
6,337,510
-
Total payables
24,616,341 13,535,720 10,980,620
100,000
141
6.5. Notes to the statement of net income
6.5.1. Accrued receivables and payables
ACCRUED RECEIVABLES
In euros
12/31/21
Discount to be obtained
20,768
352,414
373,182
Accrued government grants receivable
Total accrued receivables
ACCRUED PAYABLES
In euros
12/31/21
Convertible bond loans
- Amounts due on convertible bond loans
Loans and borrowings
- Payables
34,192
34,192
2,191
2,124
- Accrued interest payable
Trade payables and related accounts
- Suppliers
67
288,160
288,160
162,441
78,101
32,850
9,954
Tax and employee related payables
- Provisions for accrued leave
- Social charges on paid leave
- Other expenses to pay
- Ongoing training
10,454
961
- Tax charges on paid leave expenses to be paid to the state
- Provisions for accrued leave
30,122
526,983
526,983
1,013,967
Other payables
- Valuation difference of derivative financial instruments
Total accrued payables
6.5.2. Deferred revenues and expenses
DEFERRED REVENUES
In euros
12/31/21
Deferred revenues - Operating
- Deferred revenue Indivior PLC (1 year and +)
- Deferred revenue Indivior PLC (long-term)
Deferred revenues Financial
15,541,000
9,203,490
6,337,510
-
Deferred revenues - Exceptional
Total deferred revenues
-
15,541,000
142
DEFERRED EXPENSES
In euros
12/31/21
Deferred expenses - Operating
- Sundry
1,606,695
1,175,983
425,520
5,193
- Professional fees
- Insurance
Deferred expenses - Financial
Deferred expenses - Exceptional
Total deferred expenses
-
-
1,606,695
6.5.3. Exceptional income and expenses
DETAILS OF EXCEPTIONAL INCOME AND EXPENSES
In euros
12/31/21
Exceptional income from revenue transactions
- Other exceptional income from transactions
Exceptional income from capital transactions
- Share of grant transferred to profit/loss Deeptech
- Share of grant transferred to profit/loss FEDER
- Share of grant transferred to profit/loss ICOD
TOTAL EXCEPTIONAL INCOME
3,565
3,565
514,110
344
193,031
320,735
517,675
-
Exceptional expenses from revenue transactions
TOTAL EXCEPTIONAL EXPENSES
-
EXCEPTIONAL PROFIT (LOSS)
517,675
6.5.4. Income tax
BREAKDOWN OF INCOME TAX
Earnings
before tax
Profit after
tax
In euros 12/31/2021
Taxes (1)
Current Result
1,947,540
517,675
157,530
41,149
1,790,010
476,526
Exceptional Result
Accounting Result
2,465,215
198,679
2,266,536
(1) After tax restatements
The deficits remaining to be carried forward to 12/31/2021 amount to €15,322,728.
143
6.6. Financial commitments
FINANCIAL COMMITMENTS MADE AND RECEIVED
Financial
commitments
Financial
commitments
received
-
In euros 12/31/2021
made
Discounted bills not yet due
-
Endorsements, surety bonds and guarantees
Lease commitments
-
-
-
-
-
-
-
Pension, retirement and similar commitments
Other commitments
100,992
-
Total financial commitments
100,992
Commitments made
The Company has signed three exclusive patent license agreements with public institutions. These
contracts include “milestone” payment clauses based on development stages, and royalties based
on future sales. They make Aelis Farma responsible for, and financing the costs of, filing, maintain-
ing and defending these patents.
6.7. Change in Shareholders’ Equity
CHANGE IN SHAREHOLDERS’ EQUITY
Appropriation
of N- 1 net
profit (loss)
-
Changes
over the
year
In euros
12/31/20
12/31/21
Share capital
3,995
2
3,997
Additional paid-in capital
Legal reserve
934,958
-
(899,907)
35,051
-
-
-
-
Other reserves
-
-
-
-
Retained earnings (accumulated losses)
Net profit (loss) for the period
Investment grants
-
(2,783,646)
934,958
3,356,002
1,142,791
-
(1,848,688)
3,356,002
1,142,791
-
(2,783,646)
2,783,646
-
-
-
-
Regulatory provisions
Total Shareholders’ Equity
-
(1,844,693)
4,533,846
2,689,153
Allocation of the loss for the 2020 financial year
The general meeting of June 25, 2021, decided to allocate the loss for the 2020 financial year of
(€2,783,646) to the "Retained earnings” account, the balance of which will become negative by
(€2,783,646).
Clearance of part of the losses
The general meeting of June 25, 2021, decided to allocate part of the balance of the “Retained
earnings” account, namely an amount of €934,958, to the “Issue premium” account, which is thus
reduced from €934,958 at to €0. It noted that after these allocations, the balance of the “Retained
earnings” account was a negative balance of (€1,848,688).
Exercise of BSAs
On December 6, 2021, the Chairman noted that Mrs. Helle Mengel had exercised the 218 BSAoct -
2020 which had become exercisable, subscribed in cash to 218 new ordinary shares of the
144
Company, with a nominal value of €0.01 each, together with an issue premium of €58.72 each
and paid up the amount of its subscription.
Correspondingly, it noted the increase in the share capital of the Company by a nominal amount
of €2.18 and an increase in the issue premium of €12,800.96.
6.8. Separate note
6.8.1. Share warrants (BSA)
MAIN FEATURES OF THE SHARE WARRANTS ISSUED AS AT 12/31/2021
Nb. of
warrants
warrants exercised
allocated or
canceled
Nb. of
Exercise
conditions
met
(number of
shares)
Unit value
of shares
to be
Nb. of
potential
shares as
at
Unit
value of
warrants
Exercise
deadline
In euros
issued
12/31/2021
BSA - EGM
11/19/2013 et EGM
10/24/2020
355
-40
31,500
15.00
4.00 €
0.01 €
31,500
12/31/2023
12/20/2022
According
to
BSA R2017 - EGM
12/20/2017 (**)
81,949
0
formula,
maximum of
164,916
According
to
formula,
maximum of
88,544
-
0
BSA R2017 - EGM
07/19/2019 (**)
22,136
0
-
0.01 €
0
12/20/2022
BSA 2017 - EGM
12/20/2017
800
150
0
0
800
150
4.50 €
4.50 €
4.50 €
8.90 €
8.90 €
46.98
46.98
46.98
58.73
58.73
800
150
425
701
32
12/20/2027
12/20/2027
12/20/2027
10/21/2030
10/21/2030
BSA 2018 - EGM
12/18/2018
BSA 2019 - EGM
12/20/2019 (*)
600
0
600
BSA 2020 - EGM
10/24/2020 (*)
2,400
1,500
0
2,400
1,282
BSA 2021 - EGM
10/24/2020 (*)
-218
(*): 3 282 BSAs were exercised post-closing
(**): Ratchet BSAs were canceled post-closing
145
6.8.2. Founders’ share warrants (BSPCE)
MAIN FEATURES OF THE FOUNDERS’ SHARE WARRANTS ISSUED AS AT 12/31/2021
Nb. of
warrants
warrants exercised shares as
allocated or
canceled
Nb. of
potential
Unit value Exercise
Nb. of
Unit
value of
warrants
of shares
to be
conditions
met (number deadline
of warrants)
Exercise
In euros
at
issued
12/31/2021
BSPCE
EGM 06/13/2017 (*)
40
-20
2,000
15,000
3,917
6,200
4,400
1,789
-
-
-
-
-
-
25.34
46.98
46.98
58.73
58.73
58.73
20
06/13/2023
12/20/2027
12/20/2027
12/20/2027
10/23/2030
10/21/2030
BSPCE 2018
EGM 12/20/2017
15,000
9,400
6,200
4,400
1,789
0
15,000
3,917
3,383
2,900
989
BSPCE 2019
EGM 12/20/2017
-5,483
BSPCE 2020
EGM 02/18/2020
0
0
0
BSPCE 2020
EGM 10/24/2020 (*)
BSPCE 2021
EGM 10/24/2020
(*) 320 BSPCE were exercised post-closing
6.8.3. Convertibles bonds (OC)
MAIN FEATURES OF THE CONVERTIBLE BONDS ISSUED AS AT 12/31/2021
Nb. of
Unit value
of shares
to be
Exercise
conditions Exercise
met (no.
bonds)
Nb. of
bonds
allocated exercised
Nb. of
bonds
potential
shares as
at
Unit
value of
bonds
In euros
deadline
issued
12/31/2021
OC - EGM
06/29/2017 (*)
OC - AGE
07/19/2019 (*)
149
0
0
14,900
25,541
46.98 €
58.73 €
46.98 €
58.73 €
0
0
06/29/2022
07/19/2024
25,541
(*) all of the OCs were converted into ordinary shares post-closing
146
Section 7 - Auditor's reports
7.1. Statutory auditor's report on the annual financial
statements
Aelis Farma
Year ended December 31, 2021
Statutory auditor's report on the annual financial statements
To the Shareholders,
In our capacity as statutory auditor of Aelis Farma, we hereby report to you on the audit of the ac-
companying annual financial statements of Aelis Farma, for the year ended December 31, 2021.
Due to the global crisis related to the Covid-19 pandemic, the annual financial statements of this
period have been prepared and audited under specific conditions. Indeed, this crisis and the ex-
ceptional measures taken in the context of the state of sanitary emergency have had numerous
consequences for companies, particularly on their operations and their financing, and have led to
greater uncertainties on their future prospects. Those measures, such as travel restrictions and
remote working, have also had an impact on the companies' internal organization and the perfor-
mance of the audits.
The preparation of these annual financial statements is the responsibility of your Board of Direc-
tors. Our role is to express an opinion on these financial statements based on our audit.
We conducted our audit in accordance with professional standards applicable in France and the
professional guidance issued by the French Institute of statutory auditors (Compagnie nationale
des commissaires aux comptes) relating to this engagement. Those standards require that we
plan and perform the audit to obtain reasonable assurance about whether the annual financial
statements are free from material misstatement. An audit involves performing procedures, by au-
dit sampling and other means of testing, to obtain audit evidence about the amounts and disclo-
sures in the annual financial statements. An audit also includes evaluating the appropriateness of
accounting policies used and the reasonableness of accounting estimates made by management,
as well as the overall presentation of the annual financial statements. We believe that the audit
evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion.
In our opinion, the annual financial statements present fairly, in all material respects, the assets,
liabilities and financial position of the company as at December 31, 2021 and the results of its op-
erations for the year then ended, in accordance with the IFRS as adopted by the European Un-
ion.
147
This report is governed by French law. The courts of France shall have exclusive jurisdiction over
any claim or difference resulting from the engagement letter or the present report or any related
matters. Each party irrevocably waives its right to oppose any action being brought before French
courts, to claim that the action is being brought before an illegitimate court or that the courts have
no jurisdiction.
Bordeaux, April 15, 2022
The Statutory Auditor
ERNST & YOUNG Audit
Laurent Chapoulaud
148
7.2. Statutory auditor’s report on the financial statements
Aelis Farma
Year ended December 31, 2021
Statutory auditor’s report on the financial statements
To the Annual General Meeting of Aelis Farma
Opinion
In compliance with the engagement entrusted to us by your Annual General Meeting, we have au-
dited the accompanying financial statements of Aelis Farma for the year ended December 31,
2021.
In our opinion, the financial statements give a true and fair view of the assets and liabilities and of
the financial position of the Company as at December 31, 2021 and of the results of its operations
for the year then ended in accordance with French accounting principles.
The audit opinion expressed above is consistent with our report to the Audit Committee.
Basis for Opinion
Audit Framework
We conducted our audit in accordance with professional standards applicable in France. We be-
lieve that the audit evidence we have obtained is sufficient and appropriate to provide a basis for
our opinion.
Our responsibilities under those standards are further described in the Statutory Auditor’s Re-
sponsibilities for the Audit of the Financial Statements section of our report.
Independence
We conducted our audit engagement in compliance with the independence requirements of the
French Commercial Code (Code de commerce) and the French Code of Ethics for Statutory Audi-
tors (Code de déontologie de la profession de commissaire aux comptes) for the period from
January 1, 2021 to the date of our report, and specifically we did not provide any prohibited non-
audit services referred to in Article 5(1) of Regulation (EU) No. 537/2014.
Justification of Assessments Key Audit Matters
Due to the global crisis related to the Covid-19 pandemic, the financial statements for this period
have been prepared and audited under special circumstances. Indeed, this crisis and the excep-
tional measures taken in the context of the health emergency have had numerous consequences
for companies, particularly on their operations and their financing, and have led to greater uncer-
tainties regarding their future prospects. Some of these measures, such as travel restrictions and
remote working, have also had an impact on companies' internal organization and on the perfor-
mance of audits.
It is in this complex, evolving context that, in accordance with the requirements of Articles L. 823-
9 and R. 823-7 of the French Commercial Code (Code de commerce) relating to the justification
of our assessments, we inform you of the key audit matters relating to risks of material
149
misstatement that, in our professional judgment, were of most significance in our audit of the fi-
nancial statements of the current period, as well as how we addressed those risks.
These matters were addressed in the context of our audit of the financial statements as a whole
and in forming our opinion thereon, and we do not provide a separate opinion on specific items of
the financial statements.
Recognition of revenue from the exclusive license option contract with Indivior PLC
Risk identified
Our response
In June 2021, your Company entered into an in- As part of our audit, our work consisted par-
dustrial partnership in the form of an option con- ticularly in:
tract regarding the exclusive license of the in-
reading the option contract entered into
dustrial property of AEF0117 related to canna-
bis- related disorders with Indivior PLC and re-
ceived as such a payment of $ K 30,000, i.e. € K
24,616.
with Indivior P.L.C.;
reading the letter signed by Indivior
P.L.C. confirming that the exclusive li-
cense option revenue is non-refundable,
not subject to any condition precedent
and has been paid to secure the exclu-
sive license option in part considering the
provision of the results of the studies car-
ried out prior to the contract execution
date;
Recognized revenue for the fiscal year under
this contract amounts to €K 9,075.
The accounting principles applied to the recog-
nition of this revenue are described in the “Rev-
enue” paragraph of the “Accounting rules and
methods” Note to the financial statements. Two
parts are distinguished in the contract:
reviewing the analysis prepared by Man-
agement documenting the identified par-
ties.
Concerning the revenue recognized under
previous studies as available on the contract
execution date, we:
The first part concerns the results of the
work to come on phase 2b and the toxicity
studies still to be carried out. Revenue has
been allocated to this part by projecting fu-
ture costs relating to the completion of
phase 2b, including direct costs of subcon-
tracting, the direct costs of the employees
assigned to these studies and a share of the
indirect structural costs, as well as a margin.
The relevant revenue is recognized as and
when the costs relating to the performance
of these studies are recognized. As such, €K
1,154 were recognized in 2021.
reviewed the budgetary process;
evaluated the assumptions used by your
Company to determine the share of reve-
nue to be allocated to the completion of
phase 2b;
verified the arithmetical accuracy of the
calculations and in particular the differ-
ence between the total revenue and the
revenue allocated to the completion of
phase 2b, which enabled the revenue im-
mediately recognized for previous studies
to be determined.
The second part concerns the results of pre-
vious studies as available on the date of sig-
nature of the contract: the license granted to
Indivior PLC with right of return implies the
provision, on the date of signature of the
contract, of the information relating to the
Research and Development program drawn
up since the origin of the project. The reve-
nue related to this part is valued as the dif-
ference between the total amount received
and the revenue associated with the first
Regarding the revenue recognized for the
phase 2b studies carried out between the
contract execution date and the end of the fi-
nancial year, we:
evaluated the assumptions used by your
Company to determine the share of
150
part of the contract. It has been fully recog-
nized at the signature of the contract, i.e. €K
7,921 over 2021.
revenue to be allocated to the completion
of phase 2b;
compared the budgeted costs with the
costs actually incurred for the phase 2b
studies carried out during the 2021 finan-
cial year;
The remaining €K 15,541 was recognized as
deferred income for future work on phase 2b.
We considered the recognition of revenue from
the license option contract with Indivior PLC to
be a key audit matter given the complexity and
judgments required to analyze the nature of the
contractual obligations and determine the appro-
priate accounting treatment for each part of the
contract.
performed tests (invoice reconciliation,
accounting reconciliation, timesheet rec-
onciliation, etc.), by sampling, on the
costs allocated to the completion of
phase 2b over the 2021financial year;
checked the arithmetic accuracy of the
calculations.
We assessed the appropriateness of the in-
formation provided in the accompanying
Notes to the financial statements.
Specific Verifications
We have also performed, in accordance with professional standards applicable in France, the spe-
cific verifications required by laws and regulations.
Information given in the management report and in the other documents with respect to
the financial position and the financial statements provided to the shareholders
We have no matters to report as to the fair presentation and the consistency with the financial
statements of the information given in the Board of Directors’ management report and in the other
documents with respect to the financial position and the financial statements provided to the
shareholders.
We attest the fair presentation and the consistency with the financial statements of the infor-
mation relating to payment deadlines mentioned in Article D. 441-6 of the French Commercial
Code (Code de commerce).
Report on Corporate Governance
We attest that the Board of Directors’ Report on Corporate Governance sets out the information re-
quired by Articles L. 225-37-4, L. 22-10-10 and L. 22-10-9 of the French Commercial Code (Code
de commerce).
Concerning the information given in accordance with the requirements of Article L. 22-10-9 of the
French Commercial Code (Code de commerce) relating to the remuneration and benefits received
by, or allocated to the directors and any other commitments made in their favor, we have verified
its consistency with the financial statements, or with the underlying information used to prepare
these financial statements and, where applicable, with the information obtained by your Company
from companies controlled thereby, included in the consolidation scope. Based on these proce-
dures, we attest the accuracy and fair presentation of this information.
151
Other information
In accordance with French law, we have verified that the required information concerning the
identity of the shareholders and holders of voting rights has been properly disclosed in the man-
agement report.
Format of preparation of the financial statements intended to be included in the annual
financial report
We have also verified, in accordance with the professional standard applicable in France relating
to the procedures performed by statutory auditor regarding the annual and consolidated financial
statements prepared in the European single electronic format, that the preparation of the financial
statements intended to be included in the annual financial report mentioned in Article L. 451-1-2, I
of the French Monetary and Financial Code (Code monétaire et financier), prepared under the
Chairman of the Board of Directors’ responsibility, complies with the single electronic format de-
fined in Commission Delegated Regulation (EU) No. 2019/815 of 17 December 2018.
On the basis of our work, we conclude that the preparation of the financial statements intended to
be included in the annual financial report complies, in all material respects, with the European
single electronic format.
We have no responsibility to verify that the financial statements that will ultimately be included by
your Company in the annual financial report filed with the AMF (Autorité des marchés financiers)
agree with those on which we have performed our work.
Appointment of the Statutory Auditor
We were appointed as statutory auditor of Aelis Farma by your Articles of Association of October
3, 2013.
As at December 31, 2021, we were in the eighth year of total uninterrupted engagement, includ-
ing one year since the securities of the Company were admitted to trading on a regulated market.
Responsibilities of Management and Those Charged with Governance for the
Financial Statements
Management is responsible for the preparation and fair presentation of the financial statements in
accordance with French accounting principles and for such internal control as Management deter-
mines is necessary to enable the preparation of financial statements that are free from material
misstatement, whether due to fraud or error.
In preparing the financial statements, Management is responsible for assessing the Company’s
ability to continue as a going concern, disclosing, as applicable, matters related to going concern
and using the going concern basis of accounting unless it is expected to liquidate the Company or
to cease operations.
The Audit Committee is responsible for monitoring the financial reporting process and the effec-
tiveness of internal control and risk management systems and where applicable, its internal audit,
regarding the accounting and financial reporting procedures.
The financial statements were approved by the Board of Directors.
152
Statutory Auditor’s Responsibilities for the Audit of the Financial Statements
Objectives and audit approach
Our role is to issue a report on the financial statements. Our objective is to obtain reasonable as-
surance about whether the financial statements as a whole are free from material misstatement.
Reasonable assurance is a high level of assurance, but is not a guarantee that an audit con-
ducted in accordance with professional standards will always detect a material misstatement
when it exists.
Misstatements can arise from fraud or error and are considered material if, individually or in the
aggregate, they could reasonably be expected to influence the economic decisions of users made
on the basis of these financial statements.
As specified in Article L. 823-10-1 of the French Commercial Code (Code de commerce), our
statutory audit does not include assurance on the viability of the Company or the quality of man-
agement of the affairs of the Company.
As part of an audit conducted in accordance with professional standards applicable in France, the
statutory auditor exercises professional judgment throughout the audit and furthermore:
Identifies and assesses the risks of material misstatement of the financial statements,
whether due to fraud or error, designs and performs audit procedures responsive to those
risks, and obtains audit evidence considered to be sufficient and appropriate to provide a
basis for his opinion. The risk of not detecting a material misstatement resulting from
fraud is higher than for one resulting from error, as fraud may involve collusion, forgery,
intentional omissions, misrepresentations, or the override of internal control.
Obtains an understanding of internal control relevant to the audit in order to design audit
procedures that are appropriate in the circumstances, but not for the purpose of express-
ing an opinion on the effectiveness of the internal control.
Evaluates the appropriateness of accounting policies used and the reasonableness of ac-
counting estimates and related disclosures made by Management in the financial state-
ments.
Assesses the appropriateness of Management’s use of the going concern basis of ac-
counting and, based on the audit evidence obtained, whether a material uncertainty exists
related to events or conditions that may cast significant doubt on the Company’s ability to
continue as a going concern. This assessment is based on the audit evidence obtained
up to the date of his audit report. However, future events or conditions may cause the
Company to cease to continue as a going concern. If the statutory auditor concludes that
a material uncertainty exists, there is a requirement to draw attention in the audit report to
the related disclosures in the financial statements or, if such disclosures are not provided
or inadequate, to modify the opinion expressed therein.
Evaluates the overall presentation of the financial statements and assesses whether
these statements represent the underlying transactions and events in a manner that
achieves fair presentation.
Report to the Audit Committee
We submit to the Audit Committee a report which includes in particular a description of the scope
of the audit and the audit program implemented, as well as the results of our audit. We also re-
port significant deficiencies, if any, in internal control regarding the accounting and financial re-
porting procedures that we have identified.
153
Our report to the Audit Committee includes the risks of material misstatement that, in our profes-
sional judgment, were of most significance in the audit of the financial statements of the current
period and which are therefore the key audit matters that we are required to describe in this re-
port.
We also provide the Audit Committee with the declaration provided for in Article 6 of Regulation
(EU) No. 537/2014, confirming our independence within the meaning of the rules applicable in
France as set out in particular in Articles L. 822-10 to L. 822-14 of the French Commercial Code
(Code de commerce) and in the French Code of Ethics for Statutory Auditors (Code de déontolo-
gie de la profession de commissaire aux comptes). Where appropriate, we discuss with the Audit
Committee the risks that may reasonably be thought to bear on our independence, and the re-
lated safeguards.
Bordeaux, April 15, 2022
The Statutory Auditor
ERNST & YOUNG Audit
French original signed by
Laurent Chapoulaud
154
7.3. Statutory auditor’s report on related party agreements
Aelis Farma
Annual General Meeting held to approve the financial statements for the year ended December
31, 2021
Statutory auditor’s report on related party agreements
To the Annual General Meeting of Aelis Farma,
In our capacity as statutory auditor of your Company, we hereby present to you our report on re-
lated party agreements.
We are required to inform you, on the basis of the information provided to us, of the terms and
conditions of those agreements indicated to us, or that we may have identified in the performance
of our engagement, as well as the reasons justifying why they benefit the Company. We are not
required to give our opinion as to whether they are beneficial or appropriate or to ascertain the
existence of other agreements. It is your responsibility, in accordance with Article R. 225-31 of
the French Commercial Code (Code de commerce), to assess the relevance of these agreements
prior to their approval.
We are also required, where applicable, to inform you in accordance with Article R. 225-31 of the
French Commercial Code (Code de commerce) of the continuation of the implementation, during
the year ended as at December 31, 2021, of the agreements previously approved by the Annual
General Meeting.
We performed those procedures which we deemed necessary in compliance with professional
guidance issued by the French Institute of Statutory Auditors (Compagnie nationale des com-
missaires aux comptes) relating to this type of engagement. These procedures consisted in veri-
fying the consistency of the information provided to us with the relevant source documents.
Agreements submitted for approval to the Annual General Meeting
In accordance with Article L. 225-40 of the French Commercial Code (Code de commerce) , we
have been notified of the following related party agreements which received prior authorization
from your Board of Directors.
With Thomas Conseil SPRL, presided by Mr François Thomas, member of your Com-
pany’s Board of Directors
Consulting services
Nature and purpose
The purpose of the contract is to provide assistance to your Company in the search for
dilutive and non-dilutive financing and negotiation assistance.
Conditions
The Board of Directors, at its meeting of February 24, 2021, authorized your Company to
renew the consultancy contract entered into with Thomas Conseil SPRL.
155
The contract runs from January 1 to December 31, 2021, without tacit renewal. Thomas
Conseil SPRL’s compensation, initially set at € 15,000 excluding tax, was revised on July
19, 2021 and was set at € 20,000 excluding tax for the 2021 financial year.
Under this contract, the expense for the year thus amounted to 20,000.
Reasons justifying why the Company benefits from this agreement
Your Board of Directors gave the following reason: this service agreement allows your
Company to benefit from the resources and means necessary to seek any additional fi-
nancing.
Agreements previously approved by the Annual General Meeting
We hereby inform you that we have not been notified of any agreements previously approved by
the Annual General Meeting, whose implementation continued during the year ended December
31, 2021.
Bordeaux, April 15, 2022
The Statutory Auditor
ERNST & YOUNG Audit
French original signed by
Laurent Chapoulaud
156
Aelis Farma
Neurocentre Magendie
146, rue Léo Saignat
33 077 Bordeaux, France
Office : + 33 5 57 57 37 70
157