<?xml version="1.0" encoding="utf-8"?>
<?taxonomy-generator id="PomdocPro" version="2021.1.1.1" date="2025-04-22 09:42:18"?>
<linkbase 
  xmlns="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
  xmlns:xbrldt="http://xbrl.org/2005/xbrldt"
  xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"
>
  <roleRef
    roleURI="http://boiron.com/role/IncomeStatement"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#IncomeStatement"
    xlink:type="simple"
  />
  <roleRef
    roleURI="http://boiron.com/role/StatementOfComprehensiveIncome"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#StatementOfComprehensiveIncome"
    xlink:type="simple"
  />
  <roleRef
    roleURI="http://boiron.com/role/StatementOfFinancialPosition"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#StatementOfFinancialPosition"
    xlink:type="simple"
  />
  <roleRef
    roleURI="http://boiron.com/role/CashFlowStatement"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#CashFlowStatement"
    xlink:type="simple"
  />
  <roleRef
    roleURI="http://boiron.com/role/Changesinequity"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#Changesinequity"
    xlink:type="simple"
  />
  <roleRef
    roleURI="https://www.boiron.com/role/IncomeStatement2"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#IncomeStatement2"
    xlink:type="simple"
  />
  <roleRef
    roleURI="https://www.boiron.com/role/StatementOfComprehensiveIncome2"
    xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#StatementOfComprehensiveIncome2"
    xlink:type="simple"
  />
  <calculationLink xlink:role="http://boiron.com/role/IncomeStatement" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ProfitLossFromOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <loc xlink:type="locator" xlink:label="RevenueFromContractsWithCustomers" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="RevenueFromContractsWithCustomers" weight="1" xlink:title="Calculation: ProfitLossFromOperatingActivities to RevenueFromContractsWithCustomers" xlink:from="ProfitLossFromOperatingActivities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="OtherIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherIncome" weight="1" xlink:title="Calculation: ProfitLossFromOperatingActivities to OtherIncome" xlink:from="ProfitLossFromOperatingActivities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="CostOfSales" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CostOfSales"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CostOfSales" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to CostOfSales" xlink:from="ProfitLossFromOperatingActivities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="DistributionCosts" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DistributionCosts"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="DistributionCosts" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to DistributionCosts" xlink:from="ProfitLossFromOperatingActivities" order="4.0"/>
    <loc xlink:type="locator" xlink:label="SalesAndMarketingExpense" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SalesAndMarketingExpense"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="SalesAndMarketingExpense" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to SalesAndMarketingExpense" xlink:from="ProfitLossFromOperatingActivities" order="5.0"/>
    <loc xlink:type="locator" xlink:label="ResearchAndDevelopmentExpense" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ResearchAndDevelopmentExpense" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to ResearchAndDevelopmentExpense" xlink:from="ProfitLossFromOperatingActivities" order="6.0"/>
    <loc xlink:type="locator" xlink:label="RegulatoryAffairsExpense" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_RegulatoryAffairsExpense"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="RegulatoryAffairsExpense" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to RegulatoryAffairsExpense" xlink:from="ProfitLossFromOperatingActivities" order="7.0"/>
    <loc xlink:type="locator" xlink:label="AdministrativeExpense" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdministrativeExpense"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdministrativeExpense" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to AdministrativeExpense" xlink:from="ProfitLossFromOperatingActivities" order="8.0"/>
    <loc xlink:type="locator" xlink:label="MiscellaneousOtherOperatingIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="MiscellaneousOtherOperatingIncome" weight="1" xlink:title="Calculation: ProfitLossFromOperatingActivities to MiscellaneousOtherOperatingIncome" xlink:from="ProfitLossFromOperatingActivities" order="9.0"/>
    <loc xlink:type="locator" xlink:label="OtherExpenseByFunction" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherExpenseByFunction"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherExpenseByFunction" weight="-1" xlink:title="Calculation: ProfitLossFromOperatingActivities to OtherExpenseByFunction" xlink:from="ProfitLossFromOperatingActivities" order="10.0"/>
    <loc xlink:type="locator" xlink:label="ProfitLossBeforeTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <loc xlink:type="locator" xlink:label="OtherFinanceIncomeCost" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherFinanceIncomeCost"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherFinanceIncomeCost" weight="1" xlink:title="Calculation: ProfitLossBeforeTax to OtherFinanceIncomeCost" xlink:from="ProfitLossBeforeTax" order="1.0"/>
    <loc xlink:type="locator" xlink:label="InterestIncomeOnCashAndCashEquivalents" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestIncomeOnCashAndCashEquivalents"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="InterestIncomeOnCashAndCashEquivalents" weight="1" xlink:title="Calculation: ProfitLossBeforeTax to InterestIncomeOnCashAndCashEquivalents" xlink:from="ProfitLossBeforeTax" order="2.0"/>
    <loc xlink:type="locator" xlink:label="CostOfNetDebt" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_CostOfNetDebt"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CostOfNetDebt" weight="-1" xlink:title="Calculation: ProfitLossBeforeTax to CostOfNetDebt" xlink:from="ProfitLossBeforeTax" order="3.0"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProfitLossFromOperatingActivities" weight="1" xlink:title="Calculation: ProfitLossBeforeTax to ProfitLossFromOperatingActivities" xlink:from="ProfitLossBeforeTax" order="4.0"/>
    <loc xlink:type="locator" xlink:label="ProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProfitLossBeforeTax" weight="1" xlink:title="Calculation: ProfitLoss to ProfitLossBeforeTax" xlink:from="ProfitLoss" order="1.0"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxExpenseContinuingOperations" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IncomeTaxExpenseContinuingOperations" weight="-1" xlink:title="Calculation: ProfitLoss to IncomeTaxExpenseContinuingOperations" xlink:from="ProfitLoss" order="2.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod" weight="1" xlink:from="ProfitLossBeforeTax" order="11.0"/>
  </calculationLink>
  <calculationLink xlink:role="http://boiron.com/role/StatementOfComprehensiveIncome" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" weight="1" xlink:title="Calculation: OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax to OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" xlink:from="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" order="1.0"/>
    <loc xlink:type="locator" xlink:label="OtherIndividuallyImmaterialComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_OtherIndividuallyImmaterialComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherIndividuallyImmaterialComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" weight="1" xlink:title="Calculation: OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax to OtherIndividuallyImmaterialComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:from="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" order="2.0"/>
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans" weight="1" xlink:title="Calculation: OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax to OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans" xlink:from="OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" order="1.0"/>
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" weight="1" xlink:title="Calculation: OtherComprehensiveIncome to OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" xlink:from="OtherComprehensiveIncome" order="1.0"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" weight="1" xlink:title="Calculation: OtherComprehensiveIncome to OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:from="OtherComprehensiveIncome" order="2.0"/>
    <loc xlink:type="locator" xlink:label="ComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherComprehensiveIncome" weight="1" xlink:title="Calculation: ComprehensiveIncome to OtherComprehensiveIncome" xlink:from="ComprehensiveIncome" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProfitLoss" weight="1" xlink:title="Calculation: ComprehensiveIncome to ProfitLoss" xlink:from="ComprehensiveIncome" order="2.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome" weight="1" xlink:from="OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" order="4.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges" weight="1" xlink:from="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" order="5.0"/>
  </calculationLink>
  <calculationLink xlink:role="http://boiron.com/role/StatementOfFinancialPosition" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="NoncurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <loc xlink:type="locator" xlink:label="Goodwill" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Goodwill"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="Goodwill" weight="1" xlink:title="Calculation: NoncurrentAssets to Goodwill" xlink:from="NoncurrentAssets" order="1.0"/>
    <loc xlink:type="locator" xlink:label="IntangibleAssetsOtherThanGoodwill" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IntangibleAssetsOtherThanGoodwill" weight="1" xlink:title="Calculation: NoncurrentAssets to IntangibleAssetsOtherThanGoodwill" xlink:from="NoncurrentAssets" order="2.0"/>
    <loc xlink:type="locator" xlink:label="PropertyPlantAndEquipment" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PropertyPlantAndEquipment" weight="1" xlink:title="Calculation: NoncurrentAssets to PropertyPlantAndEquipment" xlink:from="NoncurrentAssets" order="3.0"/>
    <loc xlink:type="locator" xlink:label="RightofuseAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="RightofuseAssets" weight="1" xlink:title="Calculation: NoncurrentAssets to RightofuseAssets" xlink:from="NoncurrentAssets" order="4.0"/>
    <loc xlink:type="locator" xlink:label="NoncurrentFinancialAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentFinancialAssets" weight="1" xlink:title="Calculation: NoncurrentAssets to NoncurrentFinancialAssets" xlink:from="NoncurrentAssets" order="5.0"/>
    <loc xlink:type="locator" xlink:label="OtherNoncurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherNoncurrentAssets" weight="1" xlink:title="Calculation: NoncurrentAssets to OtherNoncurrentAssets" xlink:from="NoncurrentAssets" order="6.0"/>
    <loc xlink:type="locator" xlink:label="DeferredTaxAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DeferredTaxAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="DeferredTaxAssets" weight="1" xlink:title="Calculation: NoncurrentAssets to DeferredTaxAssets" xlink:from="NoncurrentAssets" order="7.0"/>
    <loc xlink:type="locator" xlink:label="CurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets"/>
    <loc xlink:type="locator" xlink:label="NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale" weight="1" xlink:title="Calculation: CurrentAssets to NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale" xlink:from="CurrentAssets" order="1.0"/>
    <loc xlink:type="locator" xlink:label="Inventories" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Inventories"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="Inventories" weight="1" xlink:title="Calculation: CurrentAssets to Inventories" xlink:from="CurrentAssets" order="2.0"/>
    <loc xlink:type="locator" xlink:label="TradeAndOtherCurrentReceivables" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="TradeAndOtherCurrentReceivables" weight="1" xlink:title="Calculation: CurrentAssets to TradeAndOtherCurrentReceivables" xlink:from="CurrentAssets" order="3.0"/>
    <loc xlink:type="locator" xlink:label="CurrentTaxAssetsCurrent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentTaxAssetsCurrent" weight="1" xlink:title="Calculation: CurrentAssets to CurrentTaxAssetsCurrent" xlink:from="CurrentAssets" order="4.0"/>
    <loc xlink:type="locator" xlink:label="OtherCurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCurrentAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherCurrentAssets" weight="1" xlink:title="Calculation: CurrentAssets to OtherCurrentAssets" xlink:from="CurrentAssets" order="5.0"/>
    <loc xlink:type="locator" xlink:label="CashAndCashEquivalents" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CashAndCashEquivalents" weight="1" xlink:title="Calculation: CurrentAssets to CashAndCashEquivalents" xlink:from="CurrentAssets" order="6.0"/>
    <loc xlink:type="locator" xlink:label="Assets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Assets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentAssets" weight="1" xlink:title="Calculation: Assets to CurrentAssets" xlink:from="Assets" order="1.0"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentAssets" weight="1" xlink:title="Calculation: Assets to NoncurrentAssets" xlink:from="Assets" order="2.0"/>
    <loc xlink:type="locator" xlink:label="Equity" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <loc xlink:type="locator" xlink:label="IssuedCapital" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapital"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IssuedCapital" weight="1" xlink:title="Calculation: Equity to IssuedCapital" xlink:from="Equity" order="1.0"/>
    <loc xlink:type="locator" xlink:label="SharePremium" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SharePremium"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="SharePremium" weight="1" xlink:title="Calculation: Equity to SharePremium" xlink:from="Equity" order="2.0"/>
    <loc xlink:type="locator" xlink:label="RetainedEarningsTreasurySharesAndAccumulatedOtherComprehensiveIncome" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_RetainedEarningsTreasurySharesAndAccumulatedOtherComprehensiveIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="RetainedEarningsTreasurySharesAndAccumulatedOtherComprehensiveIncome" weight="1" xlink:title="Calculation: Equity to RetainedEarningsTreasurySharesAndAccumulatedOtherComprehensiveIncome" xlink:from="Equity" order="3.0"/>
    <loc xlink:type="locator" xlink:label="NoncontrollingInterests" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncontrollingInterests" weight="1" xlink:title="Calculation: Equity to NoncontrollingInterests" xlink:from="Equity" order="4.0"/>
    <loc xlink:type="locator" xlink:label="NoncurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <loc xlink:type="locator" xlink:label="LongtermBorrowings" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LongtermBorrowings"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="LongtermBorrowings" weight="1" xlink:title="Calculation: NoncurrentLiabilities to LongtermBorrowings" xlink:from="NoncurrentLiabilities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="NoncurrentLeaseLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentLeaseLiabilities" weight="1" xlink:title="Calculation: NoncurrentLiabilities to NoncurrentLeaseLiabilities" xlink:from="NoncurrentLiabilities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="NoncurrentProvisionsForEmployeeBenefits" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentProvisionsForEmployeeBenefits"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentProvisionsForEmployeeBenefits" weight="1" xlink:title="Calculation: NoncurrentLiabilities to NoncurrentProvisionsForEmployeeBenefits" xlink:from="NoncurrentLiabilities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="OtherLongtermProvisions" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherLongtermProvisions"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherLongtermProvisions" weight="1" xlink:title="Calculation: NoncurrentLiabilities to OtherLongtermProvisions" xlink:from="NoncurrentLiabilities" order="4.0"/>
    <loc xlink:type="locator" xlink:label="OtherNoncurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherNoncurrentLiabilities" weight="1" xlink:title="Calculation: NoncurrentLiabilities to OtherNoncurrentLiabilities" xlink:from="NoncurrentLiabilities" order="5.0"/>
    <loc xlink:type="locator" xlink:label="DeferredTaxLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="DeferredTaxLiabilities" weight="1" xlink:title="Calculation: NoncurrentLiabilities to DeferredTaxLiabilities" xlink:from="NoncurrentLiabilities" order="6.0"/>
    <loc xlink:type="locator" xlink:label="CurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <loc xlink:type="locator" xlink:label="ShorttermBorrowings" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ShorttermBorrowings"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ShorttermBorrowings" weight="1" xlink:title="Calculation: CurrentLiabilities to ShorttermBorrowings" xlink:from="CurrentLiabilities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="CurrentLeaseLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentLeaseLiabilities" weight="1" xlink:title="Calculation: CurrentLiabilities to CurrentLeaseLiabilities" xlink:from="CurrentLiabilities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="CurrentProvisions" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentProvisions"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentProvisions" weight="1" xlink:title="Calculation: CurrentLiabilities to CurrentProvisions" xlink:from="CurrentLiabilities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="TradeAndOtherCurrentPayablesToTradeSuppliers" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="TradeAndOtherCurrentPayablesToTradeSuppliers" weight="1" xlink:title="Calculation: CurrentLiabilities to TradeAndOtherCurrentPayablesToTradeSuppliers" xlink:from="CurrentLiabilities" order="4.0"/>
    <loc xlink:type="locator" xlink:label="CurrentTaxLiabilitiesCurrent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentTaxLiabilitiesCurrent" weight="1" xlink:title="Calculation: CurrentLiabilities to CurrentTaxLiabilitiesCurrent" xlink:from="CurrentLiabilities" order="5.0"/>
    <loc xlink:type="locator" xlink:label="OtherCurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherCurrentLiabilities" weight="1" xlink:title="Calculation: CurrentLiabilities to OtherCurrentLiabilities" xlink:from="CurrentLiabilities" order="6.0"/>
    <loc xlink:type="locator" xlink:label="EquityAndLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CurrentLiabilities" weight="1" xlink:title="Calculation: EquityAndLiabilities to CurrentLiabilities" xlink:from="EquityAndLiabilities" order="1.0"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="NoncurrentLiabilities" weight="1" xlink:title="Calculation: EquityAndLiabilities to NoncurrentLiabilities" xlink:from="EquityAndLiabilities" order="2.0"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="Equity" weight="1" xlink:title="Calculation: EquityAndLiabilities to Equity" xlink:from="EquityAndLiabilities" order="3.0"/>
  </calculationLink>
  <calculationLink xlink:role="http://boiron.com/role/CashFlowStatement" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="CashFlowsFromUsedInOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <loc xlink:type="locator" xlink:label="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperatingActivities to CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:from="CashFlowsFromUsedInOperatingActivities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxesPaidRefundClassifiedAsOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IncomeTaxesPaidRefundClassifiedAsOperatingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInOperatingActivities to IncomeTaxesPaidRefundClassifiedAsOperatingActivities" xlink:from="CashFlowsFromUsedInOperatingActivities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="IncreaseDecreaseInWorkingCapital" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IncreaseDecreaseInWorkingCapital" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInOperatingActivities to IncreaseDecreaseInWorkingCapital" xlink:from="CashFlowsFromUsedInOperatingActivities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="ProfitLossAttributableToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProfitLossAttributableToOwnersOfParent" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to ProfitLossAttributableToOwnersOfParent" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="1.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForDepreciationRightOfUseAssets" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_AdjustmentsForDepreciationRightOfUseAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForDepreciationRightOfUseAssets" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to AdjustmentsForDepreciationRightOfUseAssets" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="2.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossOtherThanRightOfUseAssets" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossOtherThanRightOfUseAssets"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossOtherThanRightOfUseAssets" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossOtherThanRightOfUseAssets" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="3.0"/>
    <loc xlink:type="locator" xlink:label="OtherAdjustmentsToReconcileProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherAdjustmentsToReconcileProfitLoss"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="OtherAdjustmentsToReconcileProfitLoss" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to OtherAdjustmentsToReconcileProfitLoss" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="4.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForFinanceIncomeCost" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForFinanceIncomeCost"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForFinanceIncomeCost" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to AdjustmentsForFinanceIncomeCost" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="5.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForIncomeTaxExpenseAndAdjustmentsForDeferredTaxExpense" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_AdjustmentsForIncomeTaxExpenseAndAdjustmentsForDeferredTaxExpense"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForIncomeTaxExpenseAndAdjustmentsForDeferredTaxExpense" weight="1" xlink:title="Calculation: CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital to AdjustmentsForIncomeTaxExpenseAndAdjustmentsForDeferredTaxExpense" xlink:from="CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" order="6.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForDecreaseIncreaseInInventories" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForDecreaseIncreaseInInventories" weight="-1" xlink:title="Calculation: IncreaseDecreaseInWorkingCapital to AdjustmentsForDecreaseIncreaseInInventories" xlink:from="IncreaseDecreaseInWorkingCapital" order="1.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForDecreaseIncreaseInTradeAccountReceivable" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForDecreaseIncreaseInTradeAccountReceivable" weight="-1" xlink:title="Calculation: IncreaseDecreaseInWorkingCapital to AdjustmentsForDecreaseIncreaseInTradeAccountReceivable" xlink:from="IncreaseDecreaseInWorkingCapital" order="2.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForIncreaseDecreaseInTradeAccountPayable" weight="-1" xlink:title="Calculation: IncreaseDecreaseInWorkingCapital to AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:from="IncreaseDecreaseInWorkingCapital" order="3.0"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForDecreaseIncreaseInOtherOperatingReceivablesAndAdjustmentsForIncreaseDecreaseInOtherOperatingPayables" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_AdjustmentsForDecreaseIncreaseInOtherOperatingReceivablesAndAdjustmentsForIncreaseDecreaseInOtherOperatingPayables"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="AdjustmentsForDecreaseIncreaseInOtherOperatingReceivablesAndAdjustmentsForIncreaseDecreaseInOtherOperatingPayables" weight="-1" xlink:title="Calculation: IncreaseDecreaseInWorkingCapital to AdjustmentsForDecreaseIncreaseInOtherOperatingReceivablesAndAdjustmentsForIncreaseDecreaseInOtherOperatingPayables" xlink:from="IncreaseDecreaseInWorkingCapital" order="4.0"/>
    <loc xlink:type="locator" xlink:label="CashFlowsFromUsedInInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <loc xlink:type="locator" xlink:label="PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="4.0"/>
    <loc xlink:type="locator" xlink:label="PurchaseOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_PurchaseOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PurchaseOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to PurchaseOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="5.0"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromSalesOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_ProceedsFromSalesOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProceedsFromSalesOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to ProceedsFromSalesOfNonCurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="6.0"/>
    <loc xlink:type="locator" xlink:label="CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="7.0"/>
    <loc xlink:type="locator" xlink:label="CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInInvestingActivities to CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities" xlink:from="CashFlowsFromUsedInInvestingActivities" order="8.0"/>
    <loc xlink:type="locator" xlink:label="CashFlowsFromUsedInFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <loc xlink:type="locator" xlink:label="DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="1.0"/>
    <loc xlink:type="locator" xlink:label="DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="2.0"/>
    <loc xlink:type="locator" xlink:label="IncreaseDecreaseInIssuedCapitalSharePremiumAndOtherReservesClassifiedAsFinancingActivities" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_IncreaseDecreaseInIssuedCapitalSharePremiumAndOtherReservesClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="IncreaseDecreaseInIssuedCapitalSharePremiumAndOtherReservesClassifiedAsFinancingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to IncreaseDecreaseInIssuedCapitalSharePremiumAndOtherReservesClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="3.0"/>
    <loc xlink:type="locator" xlink:label="PaymentsToAcquireOrRedeemEntitysShares" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsToAcquireOrRedeemEntitysShares"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PaymentsToAcquireOrRedeemEntitysShares" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to PaymentsToAcquireOrRedeemEntitysShares" xlink:from="CashFlowsFromUsedInFinancingActivities" order="4.0"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromSaleOrIssueOfTreasuryShares" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSaleOrIssueOfTreasuryShares"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProceedsFromSaleOrIssueOfTreasuryShares" weight="1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to ProceedsFromSaleOrIssueOfTreasuryShares" xlink:from="CashFlowsFromUsedInFinancingActivities" order="5.0"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ProceedsFromBorrowingsClassifiedAsFinancingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="6.0"/>
    <loc xlink:type="locator" xlink:label="RepaymentsOfBorrowingsClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="RepaymentsOfBorrowingsClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to RepaymentsOfBorrowingsClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="7.0"/>
    <loc xlink:type="locator" xlink:label="InterestPaidClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="InterestPaidClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to InterestPaidClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="8.0"/>
    <loc xlink:type="locator" xlink:label="PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="9.0"/>
    <loc xlink:type="locator" xlink:label="InterestPaidOnLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_InterestPaidOnLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="InterestPaidOnLeaseLiabilitiesClassifiedAsFinancingActivities" weight="-1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to InterestPaidOnLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="10.0"/>
    <loc xlink:type="locator" xlink:label="FinanceIncomeReceivedClassifiedAsFinancingActivities" xlink:href="9695000UMPNY21KKDO98-2024-12-31.xsd#BOI_FinanceIncomeReceivedClassifiedAsFinancingActivities"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="FinanceIncomeReceivedClassifiedAsFinancingActivities" weight="1" xlink:title="Calculation: CashFlowsFromUsedInFinancingActivities to FinanceIncomeReceivedClassifiedAsFinancingActivities" xlink:from="CashFlowsFromUsedInFinancingActivities" order="11.0"/>
    <loc xlink:type="locator" xlink:label="IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
  </calculationLink>
  <calculationLink xlink:role="http://boiron.com/role/Changesinequity" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions" weight="1" xlink:from="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CancellationOfTreasuryShares" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CancellationOfTreasuryShares"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_CancellationOfTreasuryShares" weight="1" xlink:from="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" order="2.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DividendsPaid" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DividendsPaid"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_DividendsPaid" weight="-1" xlink:from="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" order="3.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ProfitLoss" weight="1" xlink:from="ifrs-full_ComprehensiveIncome" order="4.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_OtherComprehensiveIncome" weight="1" xlink:from="ifrs-full_ComprehensiveIncome" order="5.0"/>
  </calculationLink>
  <calculationLink xlink:role="https://www.boiron.com/role/IncomeStatement2" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLossAttributableToNoncontrollingInterests" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ProfitLossAttributableToNoncontrollingInterests" weight="1" xlink:from="ifrs-full_ProfitLoss" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLossAttributableToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ProfitLossAttributableToOwnersOfParent" weight="1" xlink:from="ifrs-full_ProfitLoss" order="2.0"/>
  </calculationLink>
  <calculationLink xlink:role="https://www.boiron.com/role/StatementOfComprehensiveIncome2" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ifrs-full_ComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests" weight="1" xlink:from="ifrs-full_ComprehensiveIncome" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:to="ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" weight="1" xlink:from="ifrs-full_ComprehensiveIncome" order="2.0"/>
  </calculationLink>
</linkbase>